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(Des-Tyr1)-γ-endorphin in the treatment of schizophrenia

Published online by Cambridge University Press:  09 July 2009

Rahul Manchanda  and
Steven R. Hirsch
Rahul Manchanda
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, London
Steven R. Hirsch*
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, London
*
1Address for correspondence: Professor S. R. Hirsch, Department of Psychiatry, Charing Cross Hospital Medical School, Fulham Palace Road, London W6 8RF.
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Synopsis

Inj. (Des-Tyr1)-γ-endorphin was used in a pilot study over a period of 12 days for the treatment of 11 schizophrenics and the assessments were carried out using standardized rating scales. Only 2 patients showed an improvement. Euphoria and excitement were observed in 3 patients. The findings are discussed in contrast to the earlier reports of a dramatic improvement with the compound.

Type
Brief Communication
Information
Psychological Medicine , Volume 11 , Issue 2 , May 1981 , pp. 401 - 404
Copyright
Copyright © Cambridge University Press 1981

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References

de Wied, D.Kovacs, G. L., Bohus, B., Van Ree, J. M. & Greven, H. M. (1978). Neuroleptic activity of the neuropeptide beta-LPH (Des-Tyr1)-γ-endorphin. European Journal of Pharmacology 49, 427–436.CrossRefGoogle Scholar
Emrich, H. M., Zandig, M., Kissling, W., Dirlich, G., Zerssen, D. V. & Herz, A. (1980). Des-Tyrosyl-γ-endorphin in schizophrenia: a double blind trial in 13 patients. Pharmakopsychiatrie 13, 290–298.CrossRefGoogle ScholarPubMed
Johnstone, E. C., Crow, T. J., Frith, C. D., Carney, M. W. P. & Price, J. S. (1978). Mechanism of the antipsychotic effect in the treatment of acute schizophrenia. Lancet i, 848–851.CrossRefGoogle Scholar
Jorgensen, A., Fog, R. & Vfilis, B. (1979). Synthetic enkephalin analogue in treatment of schizophrenia. Lancet i, 935.CrossRefGoogle Scholar
Knights, A., Okasha, M. S., Salih, M. A. & Hirsch, S. R. (1979). Depressive and extrapyramidal symptoms and clinical effects: a trial of fluphenazine versus flupenthixol in maintenance of schizophrenic out-patients. British Journal of Psychiatry 135, 515–523.CrossRefGoogle ScholarPubMed
Knights, A., Hirsch, S. R. & Platt, S. D. (1980). Measurement of clinical change as a function of brief admission to hospital: a controlled study. British Journal of Psychiatry 137, 170–180.CrossRefGoogle Scholar
Krawiecka, M., Goldberg, D. & Vaughan, M. (1977). A standardised psychiatric assessment scale for rating chronic psychotic patients. Acta psychiatrica scandinavica 55, 299–308.CrossRefGoogle ScholarPubMed
Overall, J. E. & Gorham, D. R. (1972). The Brief Psychiatric Rating Scale. Psychological Reports 10, 799–812.CrossRefGoogle Scholar
Verhoeven, W. M. A., Van Praag, H. M., Botter, P. A., Sunier, A., van Ree, J. M. & de Wied, D. (1978). Des-Tyr-γ-endorphin in schizophrenia. Lancet i, 1046–1047.CrossRefGoogle Scholar
Verhoeven, W. M. A., Van Praag, H. M., van Ree, J. M. & de Wied, D. (1979). Improvement of schizophrenic patients by treatment with Des-Tyr-γ-endorphin. Archives of General Psychiatry 36, 294–302.CrossRefGoogle Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar
Wing, J. K., Nixon, J. M., Mann, S. A. & Leff, J. P. (1977). Reliability of the PSE (ninth edition) used in a population study. Psychological Medicine 7, 505–516.CrossRefGoogle ScholarPubMed
Yorkston, N. J., Zaki, S. A., Malik, M. K. U.,Morrison, R. C. & Havard, C. W. H. (1974). Propranolol in the control of schizophrenic symptoms. British Medical Journal iv, 633–635.CrossRefGoogle Scholar