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Depression: why drugs and electricity are not the answer

Published online by Cambridge University Press:  01 February 2022

John Read Open the ORCID record for John Read [Opens in a new window]  and
Joanna Moncrieff
John Read*
Affiliation:
School of Psychology, University of East London, London E15 4LZ, UK
Joanna Moncrieff
Affiliation:
Division of Psychiatry, University College, London, UK
*
Author for correspondence: John Read, E-mail: [email protected]
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Abstract

The dominant view within mental health services and research suggests that feeling depressed is a kind of medical illness, partially caused by various biological deficits which are somehow corrected by physical interventions. This article critically appraises evidence for the effectiveness and value of antidepressant drugs and electroconvulsive therapy (ECT), the two principle physical treatments recommended for depression. It also describes the negative effects of these interventions and raises concerns about how they impact the brain. We propose an alternative understanding that recognises depression as an emotional and meaningful response to unwanted life events and circumstances. This perspective demands that we address the social conditions that make depression likely and suggests that a combination of politics and common sense needs to guide us in providing help for one another when we are suffering in this way. This alternative view is increasingly endorsed around the world, including by the United Nations, the World Health Organization and service users who have suffered negative consequences of physical treatments that modify brain functions in ways that are not well-understood.

Keywords

Depressionantidepressantselectroconvulsive therapyplaceboadverse effects
Type
Invited Review
Information
Psychological Medicine , Volume 52 , Issue 8 , June 2022 , pp. 1401 - 1410
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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References

American Psychiatric Association. (2001). The practice of ECT: A task force report (2nd edn). Washington, DC: A.P.A.Google Scholar
American Psychiatric Association. (2021a). What is depression? Retrieved from: https://www.psychiatry.org/patients-families/depression/what-is-depression.Google Scholar
American Psychiatric Association. (2021b). Retrieved from: https://www.psychiatry.org/patients-families/what-is-psychiatry-menu. Accessed 15th Jan 2021.Google Scholar
Bala, A., Nguyen, H., & Hellstrom, W. (2018). Post-SSRI sexual dysfunction: A literature review. Sexual Medicine Reviews, 6(1), 29–34. doi: 10.1016/j.sxmr.2017.07.002Google ScholarPubMed
Bentall, R. (2020). ECT is a classic failure of evidence-based medicine. Council for Evidence-Based Psychiatry, June 4. http://cepuk.org/2020/06/04/guest-blog-by-richard-bentall-ect-is-a-classic-failure-of-evidence-based-medicine/.Google Scholar
Bjorkenstam, E., Pebley, A., Burstrom, B., & Kosidou, K. (2017). Childhood social adversity and risk of depressive symptoms in adolescence in a US national sample. Journal of Affective Disorders, 212, 56–63. doi: 10.1016/j.jad.2017.01.035CrossRefGoogle Scholar
Bowden, G., Shankar, R., Cooke, A., & Kinderman, P. (2020). Understanding depression: Why adults experience depression and what can help. Leicester: British Psychological Society.Google Scholar
Brandon, S., Cowley, P., McDonald, C., Neville, P., Palmer, R., & Wellstood-Eason, S. (1984). ECT results in depressive illness from the Leicestershire trial. British Medical Journal, 288(6410), 22–25. https://doi.org/10.1136/bmj.288.6410.22.CrossRefGoogle Scholar
Breggin, P. (2008). Brain-disabling treatments in psychiatry (Vol. 2nd). New York: Springer.Google Scholar
Brink, S. (2020). Comment, August 7. In response to M. Vlessides (2020) Experts call for immediate suspension of ECT; Others push back. Medscape, July 24. Retrieved from: https://www.medscape.com/viewarticle/934536.Google Scholar
Brown, G., & Harris, T. (Eds.) (1978). The social origins of depression: A study of psychiatric disorder in women. London: Tavistock.Google Scholar
Cacioppo, J., Hughes, M., Waite, L., Hawkley, L., & Thisted, R. (2006). Loneliness as a specific risk factor for depressive symptoms: Cross-sectional and longitudinal analyses. Psychology of Aging, 21(1), 140–151. doi: 10.1037/0882-7974.21.1.140Google ScholarPubMed
Chen, J., Papakostas, G., Youn, S., Baer, L., Clain, A., Fava, M., & Mischoulon, D. (2011). Association between patient beliefs regarding assigned treatment and clinical response: Reanalysis of data from the Hypericum depression trial study group. Journal of Clinical Psychiatry, 72(12), 1669–1676. doi: 10.4088/JCP.10m06453Google ScholarPubMed
Coffey, C., & Kellner, C. (2021). A spirited defense of ECT. Psychiatric Times, June 7. Retrieved from: https://www.psychiatrictimes.com/view/spirited-defense-ect.Google Scholar
Cooke, A. (2017) Understanding psychosis and schizophrenia. Leicester: British Psychological Society.Google Scholar
Cromby, J., Harper, D., & Reavey, P. (2013). Psychology, mental health and distress. New York: Palgrave Macmillan.CrossRefGoogle Scholar
Cuijpers, P., Quero, S., Noma, H., Ciharova, M., Miguel, C., Karyotaki, E., … Furukawa, T. (2021). Psychotherapies for depression: A network meta-analysis covering efficacy, acceptability and long-term outcomes of all main treatment types. World Psychiatry, 20, 283–293. doi.org/10.1002/wps.20860CrossRefGoogle ScholarPubMed
Cuipers, P., Berking, M., Andersson, G., Quigley, L., Kleiboer, A., & Dobson, K. (2013). A meta-analysis of cognitive-behavioural therapy for adult depression, alone and in comparison with other treatments. Canadian Journal of Psychiatry, 58(7), 376–385. doi: 10.1177/070674371305800702.CrossRefGoogle Scholar
Davies, J., & Read, J. (2019). A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? Addictive Behaviours, 97, 111–121. doi: 10.1016/j.addbeh.2018.08.027CrossRefGoogle ScholarPubMed
Deacon, B., & Baird, G. (2009). The chemical imbalance explanation of depression: Reducing blame at what cost? Journal of Social and Clinical Psychology, 28(4), 415–435. https://doi.org/10.1521/jscp.2009.28.4.415.CrossRefGoogle Scholar
Duma, A., Maleczek, M., Panjikaran, B., Herkner, H., Karrison, T., & Nagele, P. (2019). Major adverse cardiac events and mortality associated with electroconvulsive therapy. A systematic review and meta-analysis. Anesthesiology, 130(1), 83–91. doi: 10.1097/ALN.0000000000002488Google Scholar
Eveleigh, R., Speckens, A., van Weel, C., Oude Voshaar, R., & Lucassen, P. (2019). Patients' attitudes to discontinuing not-indicated long-term antidepressant use: Barriers and facilitators. Therapeutic Advances in Psychopharmacology, 9, 2045125319872344. doi: 10.1177/2045125319872344CrossRefGoogle ScholarPubMed
Faria, V., Gingnell, M., Hoppe, J., Hjorth, O., Alaie, I., Frick, A., … Furmark, T. (2017). Do you believe it? Verbal suggestions influence the clinical and neural effects of escitalopram in social anxiety disorder: A randomized trial. EBioMedicine, 24, 179–188. doi: 10.1016/j.ebiom.2017.09.031CrossRefGoogle Scholar
Fink, M. (2021). Random controlled trial of sham electroconvulsive therapy and other novel therapies. Journal of ECT, 37(3), 150–151. doi: 10.1097/YCT.0000000000000759CrossRefGoogle ScholarPubMed
Fink, M., & Sackeim, H. (1996). Convulsive therapy in schizophrenia? Schizophrenia Bulletin, 22(1), 27–39. doi: 10.1093/schbul/22.1.27Google Scholar
Food & Drug Administration. (2020). CFR - Code of Federal Regulations Title 21; Part 882 – Neurological Devices. Retrieved from: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm?fr=882.5940.Google Scholar
Fosse, R., & Read, J. (2013). Electroconvulsive treatment: Hypotheses about mechanisms of action. Frontiers in Psychiatry, 4, 94–103. doi: 10.3389/fpsyt.2013.00094CrossRefGoogle ScholarPubMed
Framer, A. (2021). What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications. Therapeutic Advances in Psychopharmacology, 11, 2045125321991274. doi: 10.1177/2045125321991274CrossRefGoogle ScholarPubMed
Freeman, W. (1941). Brain-damaging therapeutics. Diseases of the Nervous System, 2, 83.Google Scholar
Freeths. (2021). Electroconvulsive therapy. Retrieved from: https://www.freeths.co.uk/legal-services/individuals/clinicalnegligence/electroconvulsive-therapy-ect/. Accessed December 22, 2021.Google Scholar
Friedberg, J. (1976). Shock treatment is not good for your brain. San Francisco: Glide.Google Scholar
Gibbons, R., Hur, K., Brown, C., Davis, J., & Mann, J. (2012). Benefits from antidepressants: Synthesis of 6-week patient-level outcomes from double-blind placebo-controlled randomized trials of fluoxetine and venlafaxine. Archives of General Psychiatry, 69(6), 572–579. doi: 10.1001/archgenpsychiatry.2011.2044CrossRefGoogle ScholarPubMed
Goldsmith, L., & Moncrieff, J. (2011). The psychoactive effects of antidepressants and their association with suicidality. Current Drug Safety, 6(2), 115–121. doi: 10.2174/157488611795684622Google ScholarPubMed
González-Pando, D., González-Menéndez, A., Aparicio-Basauri, V., Sanz de la Garza, C., Torracchi-Carrasco, J., & Pérez-Álvarez, M. (2021). Ethical implications of electroconvulsive therapy: A review. Ethical Human Psychology and Psychiatry, 23(1), 1–14. http://dx.doi.org/10.1891/EHPP-D-21-00002.CrossRefGoogle Scholar
Guy, W. (1976). The clinical global impression scale. In ECDEU Assessment manual for psychopharmacology- revised (pp. 218–222). Rockville, MD: US Department of Education, Health and Welfare.Google Scholar
Haddad, P., Lejoyeux, M., & Young, A. (1998). Antidepressant discontinuation reactions. British Medical Journal, 316(7138), 1105–1106. doi: 10.1136/bmj.316.7138.1105CrossRefGoogle ScholarPubMed
Hagmayer, Y., & Engelmann, L. (2014). Causal beliefs about depression in different cultural groups. Frontiers in Psychology, 5, 1303. https://doi.org/10.3389/fpsyg.2014.01303.CrossRefGoogle ScholarPubMed
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23(1), 56–62. https://doi.org/10.1136/jnnp.23.1.56.CrossRefGoogle ScholarPubMed
Harrop, C., Read, J., Geekie, J., & Renton, J. (2021). How accurate are ECT patient information leaflets provided by mental health services in England and the Royal College of how psychiatrists? An independent audit. Ethical Human Psychology and Psychiatry, 23(1), 5–24. https://doi.org/10.1891/EHPP-D-21-00003.CrossRefGoogle Scholar
Henderson, D., & Gillespie, R. D. (1962). Henderson and Gillespie's textbook of psychiatry (6th ed.). Oxford, Oxford University Press.Google Scholar
Hengartner, M., Schulthess, L., Sorensen, A., & Framer, A. (2020). Protracted withdrawal syndrome after stopping antidepressants: A descriptive quantitative analysis of consumer narratives from a large internet forum. Therapeutic Advances in Psychopharmacology, 10, 2045125320980573. doi: 10.1177/2045125320980573CrossRefGoogle ScholarPubMed
Henry, J., & Antao, C. (1992). Suicide and fatal antidepressant poisoning. European Journal of Medicine, 1(6), 343–348.Google ScholarPubMed
Hoebel, J., Maske, U. E., Zeeb, H., & Lampert, T. (2017). Social inequalities and depressive symptoms in adults: The role of objective and subjective socioeconomic Status. PLoS ONE, 12(1), e0169764. doi: 10.1371/journal.pone.0169764CrossRefGoogle ScholarPubMed
Horowitz, M., & Taylor, D. (2019). Tapering of SSRI treatment to mitigate withdrawal symptoms. The Lancet. Psychiatry, 6(6), 538–546. doi: 10.1016/S2215-0366(19)30032-XCrossRefGoogle ScholarPubMed
Hunter, A., Cook, I., Tartter, M., Sharma, S., Disse, G., & Leuchter, A. (2015). Antidepressant treatment history and drug-placebo separation in a placebo-controlled trial in major depressive disorder. Psychopharmacology (Berl), 232(20), 3833–3840. doi: 10.1007/s00213-015-4047-2CrossRefGoogle Scholar
Johnstone, E., Deakin, J., Lawler, P., Frith, C., Stevens, M., McPherson, K., & Crow, T. (1980). The Northwick park ECT trial. Lancet (London, England), 316(8208–8209), 1317–1320. https://doi.org/10.1016/S01406736(80)92393-4.CrossRefGoogle Scholar
Johnstone, L. (1999). Adverse psychological effects of ECT. Journal of Mental Health, 8(1), 69–85. https://doi.org/10.1080/09638239917652.CrossRefGoogle Scholar
Johnstone, L., Boyle, M., with Cromby, J., Dillon, J., Harper, D., Kinderman, P., … Read, J. (2018). The power threat meaning framework: Towards the identification of patterns in emotional distress, unusual experiences and troubled or troubling behaviour, as an alternative to functional psychiatric diagnosis. Leicester: British Psychological Society.Google Scholar
Johnstone, L., & Cunliffe, S. (2020). Call for an independent review into the practice of ECT. Council for Evidence-Based Psychiatry, September 7. http://cepuk.org/2020/09/07/blog-call-for-an-independent-review-into-the-practice-of-ect/.Google Scholar
Jorgensen, M., Rozing, M., Kellner, C., & Osler, M. (2020). Electroconvulsive therapy, depression severity and mortality data from the Danish National Patient Registry. Journal of Psychopharmacology, 34(3), 273–279. doi: 10.1177/0269881119895518CrossRefGoogle ScholarPubMed
Kalinowsky, L. (1986). History of convulsive therapy. Annals of the New York Academy of Sciences, 462(1), 5–11.CrossRefGoogle ScholarPubMed
Kemp, J., Lickel, J., & Deacon, B. (2014). Effects of a chemical imbalance causal explanation on individuals' perceptions of their depressive symptoms. Behaviour Research and Therapy, 56, 47–52. doi: 10.1016/j.brat.2014.02.009CrossRefGoogle ScholarPubMed
Kirsch, I., Huedo-Medina, T., Pigott, H., & Johnson, B. (2018). Do outcomes of clinical trials resemble those ‘real world’ patients? A reanalysis of the STAR-D antidepressant dataset. Psychology of Consciousness: Theory, Research and Practice, 5(4), 339–345. doi: 10.1037/cns0000164Google Scholar
Kirsch, I., & Moncrieff, J. (2007). Clinical trials and the response rate illusion. Contemporary Clinical Trials, 28(4), 348–351. https://doi.org/10.1037/cns0000164.CrossRefGoogle ScholarPubMed
Kirsch, I., Moore, T., Scoboria, A., & Nicholls, S. (2002). The emperor's new drugs: An analysis of antidepressant medication data submitted to the US Food and Drug Administration. Prevention and Treatment, 5(23). Article 23. doi: 10.1037/1522-3736.5.1.523aCrossRefGoogle Scholar
Kvaale, E., Haslam, N., & Gottdiener, W. (2013). The ‘side effects’ of medicalization: A meta-analytic review of how biogenetic explanations affect stigma. Clinical Psychology Review, 33(6), 782–794. doi: 10.1016/j.socscimed.2013.07.017CrossRefGoogle ScholarPubMed
Lambourn, J., & Gill, D. (1978). A controlled comparison of simulated and real ECT. British Journal of Psychiatry, 133, 514–519. doi.org/10.1192/bjp.133.6.514CrossRefGoogle ScholarPubMed
Lebowitz, M., & Ahn, W. (2014). Effects of biological explanations for mental disorders on clinicians’ empathy. Proceedings of the National Academy of Sciences, 111, 17786–17790. doi: 10.1073/pnas.1414058111CrossRefGoogle ScholarPubMed
Leucht, S., Fennema, H., Engel, R., Kaspers-Janssen, M., Lepping, P., & Szegedi, A. (2013). What does the HAM-D mean? Journal of Affective Disorders, 148(2–3), 243–248. doi: 10.1016/j.jad.2012.12.001CrossRefGoogle Scholar
Lewellyn, M. (2019). A Mental Health Social Prescribing Trial (British Red Cross) (PROSPECT). ClinicalTrials.gov. Retrieved from https://www.clinicaltrials.gov/ct2/show/NCT04099095.Google Scholar
Loughman, A., & Haslam, N. (2018). Neuroscientific explanations and the stigma of mental disorder: A meta-analytic study. Cognitive Research, 3, 43. doi: 10.1186/s41235-018-0136-1Google ScholarPubMed
Maund, E., Dewar-Haggart, R., Williams, S., Bowers, H., Geraghty, A., Leydon, G., … Kendrick, T. (2019). Barriers and facilitators to discontinuing antidepressant use: A systematic review and thematic synthesis. Journal of Affective Disorders, 245, 38–62. doi: 10.1016/j.jad.2018.10.107CrossRefGoogle ScholarPubMed
Mecta. (2021). Update 1. https://reorg.com/mecta-corp-first-day-declaration/Google Scholar
Moncrieff, J. (2008). The myth of the chemical cure: A critique of psychiatric drug treatment. Basingstoke, UK: Palgrave Macmillan.Google Scholar
Moncrieff, J. (2009). A straight-talking introduction to psychiatric drugs. Ross-on-Wye, UK: PCCS Books.Google Scholar
Moncrieff, J. (2020). “It was the brain tumor that done it!” Szasz and Wittgenstein on the importance of distinguishing disease from behavior and implications for the nature of mental disorder. Philosophy, Psychiatry & Psychology, 27, 169–181. doi: 10.1353/ppp.0.0023CrossRefGoogle Scholar
Moncrieff, J., & Cohen, D. (2005). Rethinking models of psychotropic drug action. Psychotherapy and Psychosomatics, 74(3), 145–153. doi: 10.1159/000083999CrossRefGoogle ScholarPubMed
Moncrieff, J., & Kirsch, I. (2015). Empirically derived criteria cast doubt on the clinical significance of antidepressant-placebo differences. Contemporary Clinical Trials, 43, 60–62. doi: 10.1016/j.cct.2015.05.005CrossRefGoogle ScholarPubMed
Moncrieff, J., Stockmann, T., Amendola, S., Hengartner, M., & Horowitz, M. (2021). The serotonin theory of depression: An umbrella review of the evidence. Molecular Psychiatry, submitted.Google Scholar
Moore, J. (2018). We've backed the wrong horse – It's time for our love affair with psychiatric drugs to end. Retrieved from https://www.madintheuk.com/2018/09/its-time-for-our-love-affair-with-psychiatric-drugs-to-end/. Accessed 13th July 2021.Google Scholar
Munk-Olsen, T., Laursen, T., Videbech, P., Mortensen, P., & Rosenberg, R. (2007). All-cause mortality among recipients of electroconvulsive therapy: Register-based cohort study. British Journal of Psychiatry, 190, 435–439. doi: 10.1192/bjp.bp.106.026740CrossRefGoogle ScholarPubMed
Mutz, J., Vipulananthan, V., Carter, B., Hurlemann, R., Fu, C., & Young, A. (2019). Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: Systematic review and network meta-analysis. British Medical Journal, 364, l1079. https://doi.org/10.1136/bmj.l1079.CrossRefGoogle ScholarPubMed
Myerson, A. (1942). Fatalities following ECT. Transactions of the American Neurological Association, 68, 39.Google Scholar
Olfson, M., Wang, S., Wall, M., Marcus, S., & Blanco, C. (2019). Trends in serious psychological distress and outpatient mental health care of US adults. JAMA Psychiatry, 76(2), 152–161. doi: 10.1001/jamapsychiatry.2018.3550CrossRefGoogle ScholarPubMed
Organisation for Economic Co-Operation and Development (OECD). (2020). Statistics Health Status. Retrieved from: https://stats.oecd.org/index.aspx?DataSetCode=HEALTH_STAT#. Accessed 16th May 2020.Google Scholar
Padala, P., Padala, K., Majagi, A., Garner, K., Dennis, R., & Sullivan, D. (2020). Selective serotonin reuptake inhibitors-associated apathy syndrome: A cross-sectional study. Medicine (Baltimore), 99(33), e21497. doi: 10.1097/MD.0000000000021497CrossRefGoogle ScholarPubMed
Peltzman, T., Shiner, B., & Watts, B. (2020). Effects of electroconvulsive therapy on short-term suicide mortality in a risk-matched patient population. Journal of ECT, 36(3), 187–192. doi: 10.1097/YCT.0000000000000665CrossRefGoogle Scholar
Perrin, J., Merz, S., Bennett, D., Currie, J., Steele, D., Reid, I., & Schwarzbauer, C. (2012). Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. Proceedings of the National Academy of Sciences, 109(14), 5464–5468. doi: 10.1073/pnas.1117206109CrossRefGoogle ScholarPubMed
Pigott, H. (2015). The STAR*D trial: It is time to reexamine the clinical beliefs that guide the treatment of major depression. Canadian Journal of Psychiatry, 60(1), 9–13. doi: 10.1177/070674371506000104CrossRefGoogle ScholarPubMed
Pigott, H., Leventhal, A., Alter, G., & Boren, J. (2010). Efficacy and effectiveness of antidepressants: Current status of research. Psychotherapy and Psychomatics, 79(5), 267–279. https://doi.org/10.1159/000318293.CrossRefGoogle ScholarPubMed
Pilkington, P., Reavley, N., & Jorm, A. (2013). The Australian public's beliefs about the causes of depression: Associated factors and changes over 16 years. Journal of Affective Disorders, 150(2), 356–362. doi: 10.1016/j.jad.2013.04.019CrossRefGoogle ScholarPubMed
Postmes, T., Wichmann, L., van Valkengoed, A., & van der Hoef, H. (2018). Social identification and depression: A meta-analysis. European Journal of Social Psychology, 49, 110–126. doi: 10.1002/ejsp.2508CrossRefGoogle Scholar
Price, J., Cole, V., & Goodwin, G. (2009). Emotional side-effects of selective serotonin reuptake inhibitors: Qualitative study. British Journal of Psychiatry, 195(3), 211–217. doi: 10.1192/bjp.bp.108.051110CrossRefGoogle ScholarPubMed
Puras, D. (2019). Report of the Special Rapporteur on the right of everyone to the enjoyment of the highest attainable standard of physical and mental health. United Nations Human Rights Council, 24 June-12 June. Retrieved from: https://www.un.org/en/ga/search/view_doc.asp?symbol=A/HRC/41/34.Google Scholar
Rasmussen, K. (2009). Sham ECT studies in depressive illness. Journal of ECT, 25(1), 54–59. doi: 10.1097/YCT.0b013e3181719b23CrossRefGoogle ScholarPubMed
Read, J. (2020). Electroshock therapy: From research to action. Psychology Today, August 24. Retrieved from: https://www.psychologytoday.com/gb/blog/psychiatry-through-the-looking-glass/202008/electroshock-therapy-research-action.Google Scholar
Read, J. (2021). W.H.O. and U.N. join calls to transcend medical model. Psychology Today, June 22. Retrieved from: https://www.psychologytoday.com/gb/blog/psychiatry-through-the-looking-glass/202106/who-and-un-join-calls-transcend-the-medical-model.Google Scholar
Read, J. (2022). A response to yet another defence of ECT in the absence of robust efficacy and safety evidence. Epidemiology and Psychiatric Sciences. In press.CrossRefGoogle ScholarPubMed
Read, J., & Arnold, C. (2017). Is electroconvulsive therapy for depression more effective than placebo? A systematic review of studies since 2009. Ethical Human Psychology and Psychiatry, 19(1), 5–23. https://doi.org/10.1891/1559-4343.19.1.5.CrossRefGoogle Scholar
Read, J., & Bentall, R. (2010). The effectiveness of electroconvulsive therapy: A literature review. Epidemiology and Psychiatric Sciences, 19(4), 333–347. https://doi.org/10.1017/S1121189X00000671.Google ScholarPubMed
Read, J., Bentall, R., Johnstone, L., Fosse, R., & Bracken, P. (2013a). Electroconvulsive therapy. In Read, J. & Dillon, J. (Eds.), Models of madness: Psychological, social and biological approaches to psychosis (2nd ed., pp. 90–104). Hove, UK: Routledge. https://doi.org/10.4324/9780203527160.CrossRefGoogle Scholar
Read, J., Cartwright, C., Gibson, K., Shiels, C., & Haslam, N. (2014). Beliefs of people taking antidepressants about causes of depression and reasons for increased prescribing rates. Journal of Affective Disorders, 168, 236–242. doi: 10.1016/j.jad.2014.06.010Google ScholarPubMed
Read, J., Gibson, K., Cartwright, C., Shiels, C., Dowrick, C., & Gabbay, M. (2015). Understanding the non-pharmacological correlates of self-reported efficacy of antidepressants. Acta Psychiatrica Scandinavica, 131(6), 434–445. doi: 10.1111/acps.12390CrossRefGoogle ScholarPubMed
Read, J., Hancock, S., & Cunliffe, S. (2021a). ECT: Dangerous on either side of the pond. Psychiatric Times, 38(4), 4–7. Retrieved from: https://www.psychiatrictimes.com/view/ect-dangerous-either-side-pond.Google Scholar
Read, J., & Harper, D. (2020). The power threat meaning framework: Addressing adversity, challenging prejudice and stigma and transforming services. Journal of Constructivist Psychology. Published online: doi: 10.1080/10720537.2020.1773356Google Scholar
Read, J., Harrop, C., Geekie, J., & Renton, J. (2018). An audit of ECT in England 2011–2015: Usage, demographics, and adherence to guidelines and legislation. Psychology and Psychotherapy: Theory, Research and Practice, 91(3), 263–277. doi: 10.1111/papt.12160CrossRefGoogle ScholarPubMed
Read, J., Harrop, C., Geekie, J., Renton, J., & Cunliffe, S. (2021b). A second independent audit of ECT in England: Usage, demographics, consent, and adherence to guidelines and legislation in 2019. Psychology and Psychotherapy: Theory, 94(3), 603–619. 10.1111/papt.12335.CrossRefGoogle Scholar
Read, J., Haslam, N., & Magliano, L. (2013b). Prejudice, stigma and ‘schizophrenia’: The role of bio-genetic ideology. In Read, J. & Dillon, J. (Eds.), Models of madness: Psychological, social and biological approaches to psychosis (2nd ed., pp. 143–156). Hove, UK: Routledge. https://doi.org/10.4324/9780203527160.Google Scholar
Read, J., Kirsch, I., & McGrath, L. (2019). Electroconvulsive therapy for depression: A review of the quality of ECT vs sham ECT trials and meta-analyses. Ethical Human Psychiatry and Psychology, 21(2), 64–103. doi: 10.1891/EHPP-D-19-00014Google Scholar
Read, J., & Sanders, P. (2010). A straight-talking introduction to the causes of mental health problems. Ross-on-Wye, UK: PCCS Books.Google Scholar
Read, J., & Williams, J. (2018). Adverse effects of antidepressants reported by a large international cohort: Emotional blunting, suicidality, and withdrawal effects. Current Drug Safety, 13(3), 176–186. doi: 10.2174/1574886313666180605095130CrossRefGoogle ScholarPubMed
Reangsing, C., Rittiwong, T., & Schneider, J. K. (2021). Effects of mindfulness meditation interventions on depression in older adults: A meta-analysis. Aging Mental Health, 25(7), 1181–1190. doi: 10.1080/13607863.2020.1793901CrossRefGoogle ScholarPubMed
Ronnqvist, I., Nilsson, F., & Nordenskjold, A. (2021). Electroconvulsive therapy and the risk of suicide with major depressive disorder. JAMA Network Open, 4(7), e2116589. doi: 10.1001/jamanetworkopen.2021.16589CrossRefGoogle ScholarPubMed
Rose, D., Wykes, T., Leese, J., Bindmann, J., & Fleischmann, P. (2003). Patients' perspectives of electroconvulsive therapy: Systematic review. British Medical Journal, 326, 1363–1366. doi: 10.1136/bmj.326.7403.1363.CrossRefGoogle ScholarPubMed
Ross, C. (2006). The sham ECT literature: Implications for consent to ECT. Ethical Human Psychology and Psychiatry, 8, 17–28.CrossRefGoogle ScholarPubMed
Rush, A., Trivedi, M., Wisniewski, S., Nierenberg, A., Stewart, J., Warden, D., … Fava, M. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A STAR*D report. American Journal of Psychiatry, 163(11), 1905–1917. Retrieved from PM:17074942.CrossRefGoogle ScholarPubMed
Rutherford, B., Sneed, J., & Roose, S. (2009). Does study design influence outcome?. The effects of placebo control and treatment duration in antidepressant trials. Psychotherapy and Psychosomatics, 78(3), 172–181. doi: 10.1159/000209348CrossRefGoogle ScholarPubMed
Sackeim, H., Prudic, J., Fuller, R., Keilp, J., Lavori, P., & Olfson, M. (2007). The cognitive effects of ECT in community settings. Neuropsychopharmocology, 32(1), 244–254. doi: 10.1038/sj.npp.1301180CrossRefGoogle ScholarPubMed
Schuch, F. B., Vancampfort, D., Richards, J., Rosenbaum, S., Ward, P. B., & Stubbs, B. (2016). Exercise as a treatment for depression: A meta-analysis adjusting for publication bias. Journal of Psychiatric Research, 77, 42–51. doi: 10.1016/j.jpsychires.2016.02.023CrossRefGoogle ScholarPubMed
Simonsen, A., Danborg, P., & Gotzsche, P. (2016). Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies. International Journal of Risk & Safety in Medicine, 28(1), 1–12. doi: 10.3233/JRS-160668CrossRefGoogle ScholarPubMed
Somatics. (2018). Regulatory update to Thymatron system IV instruction manual. Retrieved from: http://www.thymatron.com/downloads/System_IV_Regulatory_Update.pdf.Google Scholar
Speed, E., Moncrieff, J., & Rapley, M. (Eds). (2014). De-medicalising misery II. Basingstoke, UK: Palgrave Macmillan.Google Scholar
Sugarman, M., Loree, A., Baltes, B., Grekin, E., & Kirsch, I. (2014). The efficacy of paroxetine and placebo in treating anxiety and depression: A meta-analysis of change on the Hamilton rating scales. PLoS One. 9(8), e106337. doi: 10.1371/journal.pone.0106337CrossRefGoogle ScholarPubMed
Taylor, S., Annand, F., Burkinshaw, P., Greaves, F., Kelleher, M., Knight, J., … Marsden, J. (2019). Dependence and withdrawal associated with some prescribed medicines: an evidence review. Public Health England. Retrieved from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/940255/PHE_PMR_report_Dec2020.pdf.Google Scholar
Tsai, J., Peltzman, T., Watts, B., & Shiner, B. (2021). Effects of electroconvulsive therapy on suicidal behavior and emergency department use among homeless veterans: A propensity score-matched study. Journal of Clinical Psychiatry, 82(6), 21m13935. doi: 10.4088/JCP.21m13935Google ScholarPubMed
Turner, E., Matthews, A., Linardatos, E., Tell, R., & Rosenthal, R. (2008). Selective publication of antidepressant trials and its influence on apparent efficacy. New England Journal of Medicine, 358(3), 252–260. doi: 10.1056/NEJMsa065779CrossRefGoogle ScholarPubMed
Valenstein, E. (1988). Blaming the brain. New York: Free Press.Google Scholar
Viola, S., & Moncrieff, J. (2016). Claims for sickness and disability benefits owing to mental disorders in the UK: Trends from 1995 to 2014. BJPsych Open, 2(1), 18–24. doi: 10.1192/bjpo.bp.115.002246CrossRefGoogle ScholarPubMed
Vlessides, M. (2020). Experts call for immediate suspension of ECT; Others push back. Medscape, July 24. Retrieved from: https://www.medscape.com/viewarticle/934536.Google Scholar
Wampold, B., Minami, T., Baskin, T., & Callen Tierney, S. (2002). A meta-(re)analysis of the effects of cognitive therapy versus ‘other therapies’ for depression. Journal of Affective Disorders, 68(2–3), 159–165. doi: 10.1016/s0165-0327(00)00287-1CrossRefGoogle ScholarPubMed
Wei, Q., Bai, T., Chen, Y., Ji, G., Hu, X., Xie, W., … Tian, Y. (2018). The changes of functional connectivity strength in electroconvulsive therapy for depression: A longitudinal study. Frontiers in Neuroscience, 12, 661. doi: 10.3389/fnins.2018.00661CrossRefGoogle ScholarPubMed
Wells, K., Hancock, N., & Honey, A. (2021). How do people perceive and adapt to any consequences of electro convulsive therapy on their daily lives?. Community Mental Health Journal. doi: 10/1007’s10597-00913-7.CrossRefGoogle ScholarPubMed
World Health Organization (2021). Guidance on community mental health services: Promoting person-centred and rights-based approaches. https://www.who.int/publications/i/item/9789240025707.Google Scholar
Zahodne, L., Bernal-Pacheco, O., Bowers, D., Ward, H., Oyama, G., Limotai, N., … Okun, M. (2012). Are selective serotonin reuptake inhibitors associated with greater apathy in Parkinson's disease? Journal of Neuropsychiatry and Clinical Neurosciences, 24(3), 326–330. doi: 10.1176/appi.neuropsych.11090210CrossRefGoogle ScholarPubMed