Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-06T00:24:16.324Z Has data issue: false hasContentIssue false
  • English
  • Français

Dementia in idiopathic Parkinson's disease: prevalence and relationship with symptoms and signs of Parkinsonism

Published online by Cambridge University Press:  09 July 2009

K. P. Ebmeier ,
S. A. Calder ,
J. R. Crawford ,
L. Stewart ,
R. H. B. Cochrane  and
J. A. O. Besson
K. P. Ebmeier*
Affiliation:
Department of Mental Health, University of Aberdeen
S. A. Calder
Affiliation:
Department of Mental Health, University of Aberdeen
J. R. Crawford
Affiliation:
Department of Mental Health, University of Aberdeen
L. Stewart
Affiliation:
Department of Mental Health, University of Aberdeen
R. H. B. Cochrane
Affiliation:
Department of Mental Health, University of Aberdeen
J. A. O. Besson
Affiliation:
Department of Mental Health, University of Aberdeen
*
1Address for correspondence: Dr K. P. Ebmeier, MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF.
Get access Rights & Permissions [Opens in a new window]

Synopsis

A whole population cohort of 157 patients with idiopathic Parkinsonism, most of whom had previously been clinically examined by Mutch (1986 a), were assessed to determine prevalence figures for dementia and examine the relationship between dementia, cognitive impairment and Parkinsonian signs. Dementia according to DSM-III-R criteria was diagnosed in 23·3% of all patients (95% confidence interval: 17·1 to 32·4%). Dementia and cognitive impairment were associated with overall measures of Parkinsonian impairment and rigidity, but not tremor, even after controlling for age, sex and education.

Type
Original Articles
Information
Psychological Medicine , Volume 21 , Issue 1 , February 1991 , pp. 69 - 76
Copyright
Copyright © Cambridge University Press 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1987). Diagnostic Criteria from DSM-III-R. Press Syndicate of the University of Cambridge: Cambridge.Google Scholar
Anthony, J. C., Le Resche, L. A., Niaz, U, von Korf, M. R. & Folstein, M. F. (1982). Limits to the Mini-Mental State as a screening test for dementia and delirium among hospital patients. Psychological Medicine 12, 397–408.CrossRefGoogle Scholar
Barbeau, A. (1986). Parkinson's disease: clinical features and etiopathology. In Handbook of Neurological Disorders, Vol. 49, Revised Series 5, Extrapyramidal Disorders (ed. Vinken, P. J., Bruyn, G. W. and Klawans, H. L.) pp. 87–152. Elsevier: Amsterdam.Google Scholar
Breslow, N. E. & Day, N. E. (1980). Statistical methods in Cancer Research, vol. 1. International Agency for Research on Cancer: Lyon.Google Scholar
Brown, R. G. & Marsden, C. D. (1984). How common is dementia in Parkinson's disease? Lancet ii, 1262–1265.CrossRefGoogle Scholar
Celesia, G. C. & Wanamaker, W. M. (1972). Psychiatric disturbance in Parkinson's disease. Diseases of the Nervous System 33, 577–583.Google ScholarPubMed
Cho, A. K., Haslen, W. L. & Jenden, D. J. (1962). The peripheral actions of oxotremorine, a metabolite of tremorine. Journal of Pharmacology and Experimental Therapeutics 138, 249–257.Google ScholarPubMed
Crawford, J. R., Besson, J. A. O. & Ebmeier, K. P. (1990). Dementia. In Principles and Practice of Biological Psychiatry. (ed. Dinan, P. G.). pp. 105–133. Clinical Neuroscience Publishers: London.Google Scholar
Crawford, J. R., Stewart, L., Calder, S., Ebmeier, K., Mutch, W. & Besson, J. (1988). Estimation of pre-morbid intelligence in idiopathic Parkinson's disease.Abstracts, 9th International Symposium on Parkinson's Disease,Jerusalem, p. 46.Google Scholar
Eastwood, M. R. & Corbin, S. L. (1985). Epidemiology of mental disorders in old age In Recent Advances in Psychogeriatrics, vol. 1 (ed. Arie, T.), pp. 17–32. Churchill Livingstone: Edinburgh.Google Scholar
Ebmeier, K. P., Besson, J. A. O., Blackwood, G. W., Eagles, J. M., Beattie, J. A. G., Hunter, D. & Ashcroft, G. W. (1988). Continuing care of the demented elderly in Inverurie. Scottish Home and Health Department Health Bulletin 46, 32–41.Google ScholarPubMed
Ebmeier, K. P., Mutch, W. J., Calder, S. A., Crawford, J. R., Stewart, L. & Besson, J. A. O. (1989). Does idiopathic Parkinson's disease in Aberdeen follow intra-uterine influenza? Journal of Neurology, Neurosurgery and Psychiatry 52, 911–913.CrossRefGoogle Scholar
Ebmeier, K. P., Calder, S. A., Crawford, J. R., Stewart, L., Besson, J. A. O. & Mutch, W. J. (1990 a). Clinical features predicting dementia in idiopathic Parkinson's disease: a follow-up study. Neurology 40, 1222–1224.CrossRefGoogle ScholarPubMed
Ebmeier, K. P., Calder, S. A., Crawford, J. R., Stewart, L., Besson, J. A. O. & Mutch, W. J. (1990 b). Parkinson's disease in Aberdeen: survival after 31/2 years. Acta Neurologica Scandinavica 81, 294–299.CrossRefGoogle Scholar
Ebmeier, K. P., Calder, S. A., Crawford, J. R., Stewart, L., Besson, J. A. O. & Mutch, W. J. (1990 c). Mortality and causes of death in idiopathic Parkinson's disease: results from the Aberdeen whole population study. Scottish Medical Journal (in the press).CrossRefGoogle Scholar
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975). Mini-Mental State, a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189–198.CrossRefGoogle Scholar
Gardner, M. J. & Altman, D. G. (1989). Statistics with Confidence Confidence Intervals and Statistical Guidelines. BMJ: London.Google Scholar
Gibb, W. R. G. (1989). Dementia and Parkinson's disease. British Journal of Psychiatry 154, 596–614.CrossRefGoogle ScholarPubMed
Gilleard, C. J. & Pattie, A. H. (1977). The Stockton geriatric rating scale: a shortened version with British normative data. British Journal of Psychiatry 131, 90–94.CrossRefGoogle Scholar
Hoehn, M. M. & Yahr, M. D. (1967). Parkinsonism: onset progression, and mortality. Neurology 17, 427–442.CrossRefGoogle ScholarPubMed
Marttila, R. J. & Rinne, U. K. (1976). Dementia in Parkinson's disease. Acta Neurologica Scandinavica 54, 431–441.CrossRefGoogle ScholarPubMed
Mayeux, R., Stem, Y., Rosenstein, R., Marder, K., Hauser, A., Cote, L. & Fahn, S. (1988). An estimate of the prevalence of dementia in idiopathic Parkinson's disease. Archives of Neurology 45, 260–262.CrossRefGoogle ScholarPubMed
Medical Research Council (1987). Report from the MRC Alzheimer's Disease Workshop. MRC: London.Google Scholar
Mindham, R. H. S., Marsden, C. D. & Parkes, J. D. (1976). Psychiatric symptoms during L-DOPA therapy for Parkinson's disease and their relationship to physical disability. Psychological Medicine 6, 23–33.CrossRefGoogle ScholarPubMed
Mindham, R. H. S., Ahmed, S. W. A. & Clough, C. G. (1982). A controlled study of dementia in Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry 45, 969–974.CrossRefGoogle ScholarPubMed
Mutch, W. J., Dingwall-Fordyce, I., Downie, A. W., Paterson, J. G. & Roy, S. K. (1986 a). Parkinson's disease in a Scottish city. British Medical Journal 292, 534–536.CrossRefGoogle Scholar
Mutch, W. J., Strudwick, A., Roy, S. K. & Downie, A. W. (1986 b). Parkinson's disease: disability, review, and management. British Medical Journal 293, 675–677.CrossRefGoogle ScholarPubMed
Norusis, M. J. (1985). SPSSX Advanced Statistics Guide, pp. 73–122. McGraw-Hill: New York.Google Scholar
Office of Population Censuses and Surveys (1980). Classification of Occupations. HMSO: London.Google Scholar
Oyebode, J. R., Barker, W. A., Blessed, G., Dick, D. J. & Britton, P. G. (1986). Cognitive functioning in Parkinson's disease: in relation to prevalence of dementia and psychiatric diagnosis. British Journal of Psychiatry 149, 720–725.CrossRefGoogle ScholarPubMed
Pattie, A. (1988). Measuring levels of disability – the Clifton assessment procedures for the elderly. In Psychological Assessment for the Elderly (ed. Wattis, J. P. and Hindmarch, I.) pp. 61–80. Churchill Livingstone: Edinburgh.Google Scholar
Pollock, M. & Hornabrook, M. (1966). The prevalence, natural history and dementia of Parkinson's disease. Brain 89, 86–90.CrossRefGoogle ScholarPubMed
Quinn, N., Brown, R. & Marsden, C. D. (1986). Dementia and Parkinson's disease – a review of the current evidence. In Psychiatric Disorders in the Elderly (ed. Bebbington, P. E. and Jacoby, R.) pp. 25–53. Mental Health Foundation: London.Google Scholar
Rabins, P. V. & Folstein, M. F. (1982). Delirium and dementia: diagnostic criteria and fatality rates. British Journal of Psychiatry 140, 149–153.CrossRefGoogle ScholarPubMed
Rajput, A. H. (1984). Epidemiology of Parkinson's disease. Canadian Journal of Neurological Sciences 11, 156–159.CrossRefGoogle ScholarPubMed
Snaith, R. P., Bridge, G. W. & Hamilton, M. (1976). The Leeds scales for the self-assessment of anxiety and depression. British Journal of Psychiatry 128, 156–165.CrossRefGoogle ScholarPubMed
Sutcliffe, R. L. G., Prior, R., Mawby, B. & McQuillan, W. J. (1985). Parkinson's disease in the district of the Northampton Health Authority, United Kingdom. A study of prevalence and disability. Acta Neurologica Scandinavica 72, 363–379.CrossRefGoogle ScholarPubMed
Sweet, R. D., McDowell, F. H., Feigenson, J. S., Loranger, A. W. & Goodell, H. (1976). Mental symptoms in Parkinson's disease during chronic treatment with levodopa. Neurology 26, 305–310.CrossRefGoogle ScholarPubMed
Webster, D. D. (1968). Critical analyses of the disability in Parkinson's disease. Modern Treatment 5, 257–282.Google Scholar
Wilson, L. A. & Brass, W. (1973). Brief assessment of the mental state in geriatric domiciliary practice. The usefulness of the mental status questionnaire. Age and Ageing 2, 92–101.CrossRefGoogle Scholar
Zetusky, W. J., Jancovic, J. & Pirozzolo, F. J. (1985). The heterogeneity of Parkinson's disease: clinical and prognostic implications. Neurology 35, 522–526.CrossRefGoogle ScholarPubMed