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Default mode network abnormalities during state switching in attention deficit hyperactivity disorder

Published online by Cambridge University Press:  12 October 2015

J. Sidlauskaite ,
E. Sonuga-Barke ,
H. Roeyers  and
J. R. Wiersema
J. Sidlauskaite*
Affiliation:
Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium
E. Sonuga-Barke
Affiliation:
Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium Developmental Brain-Behaviour Unit, Psychology, University of Southampton, Shackleton Building (B44), Highfield Campus, Southampton, UK
H. Roeyers
Affiliation:
Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium
J. R. Wiersema
Affiliation:
Department of Experimental-Clinical and Health Psychology, Ghent University, Ghent, Belgium
*
*Address for correspondence: J. Sidlauskaite, Department of Experimental-Clinical and Health Psychology, Ghent University, Henri Dunantlaan 2, Ghent B-9000, Belgium. (Email: [email protected])
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Abstract

Background

Individuals with attention deficit hyperactivity disorder (ADHD) display excess levels of default mode network (DMN) activity during goal-directed tasks, which are associated with attentional disturbances and performance decrements. One hypothesis is that this is due to attenuated down-regulation of this network during rest-to-task switching. A second related hypothesis is that it may be associated with right anterior insula (rAI) dysfunction – a region thought to control the actual state-switching process.

Method

These hypotheses were tested in the current fMRI study in which 19 adults with ADHD and 21 typically developing controls undertook a novel state-to-state switching paradigm. Advance cues signalled upcoming switches between rest and task periods and switch-related anticipatory modulation of DMN and rAI was measured. To examine whether rest-to-task switching impairments may be a specific example of a more general state regulation deficit, activity upon task-to-rest cues was also analysed.

Results

Against our hypotheses, we found that the process of down-regulating the DMN when preparing to switch from rest to task was unimpaired in ADHD and that there was no switch-specific deficit in rAI modulation. However, individuals with ADHD showed difficulties up-regulating the DMN when switching from task to rest.

Conclusions

Rest-to-task DMN attenuation seems to be intact in adults with ADHD and thus appears unrelated to excess DMN activity observed during tasks. Instead, individuals with ADHD exhibit attenuated up-regulation of the DMN, hence suggesting disturbed re-initiation of a rest state.

Keywords

Attention deficit hyperactivity disorderdefault mode networkinsulastate switching
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 3 , February 2016 , pp. 519 - 528
Copyright
Copyright © Cambridge University Press 2015 

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