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A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression

Published online by Cambridge University Press:  15 May 2006

JOSEPH BIEDERMAN ,
CARTER PETTY ,
DINA R. HIRSHFELD-BECKER ,
AUDE HENIN ,
STEPHEN V. FARAONE ,
DANIELLE DANG ,
ALEKSANDRA JAKUBOWSKI  and
JERROLD F. ROSENBAUM
JOSEPH BIEDERMAN
Affiliation:
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
CARTER PETTY
Affiliation:
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
DINA R. HIRSHFELD-BECKER
Affiliation:
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
AUDE HENIN
Affiliation:
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
STEPHEN V. FARAONE
Affiliation:
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA
DANIELLE DANG
Affiliation:
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
ALEKSANDRA JAKUBOWSKI
Affiliation:
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
JERROLD F. ROSENBAUM
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
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Abstract

Background. To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence.

Method. Over a 5-year follow-up, we compared psychiatric disorders in four groups of children: (1) offspring of parents with PD plus MD (n=136); (2) offspring of parents with PD without MD (n=27); (3) offspring of parents with MD but without PD (n=53); and (4) offspring of non-PD non-MD parents (n=103).

Results. Parental PD was significantly associated with increased risk for anxiety disorders, irrespective of parental MD. Parental MD was associated with increased risk for MD, disruptive behavior disorders, and deficits in psychosocial functioning, irrespective of parental PD.

Conclusions. These longitudinal findings confirm and extend previous cross-sectional results documenting significant associations between PD and MD in parents and patterns of psychopathology and dysfunction in their offspring.

Type
Original Article
Information
Psychological Medicine , Volume 36 , Issue 8 , August 2006 , pp. 1141 - 1152
Copyright
© 2006 Cambridge University Press

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