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Cognitive inhibition in depression and suicidal behavior: a neuroimaging study

Published online by Cambridge University Press:  16 December 2015

S. Richard-Devantoy ,
Y. Ding ,
M. Lepage ,
G. Turecki  and
F. Jollant
S. Richard-Devantoy
Affiliation:
Department of Psychiatry & Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Québec, Canada Hôpital de Saint-Jérôme, Saint-Jérôme (Qc), Canada and Laboratoire de Psychologie des Pays de la Loire, UPRES EA 4638, Université d'Angers, Angers, France
Y. Ding
Affiliation:
Department of Psychiatry & Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Québec, Canada
M. Lepage
Affiliation:
Department of Psychiatry & Douglas Mental Health University Institute, McGill University, Montréal, Québec, Canada
G. Turecki
Affiliation:
Department of Psychiatry & Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Québec, Canada
F. Jollant*
Affiliation:
Department of Psychiatry & Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Québec, Canada Department of Psychiatry, CHU Nîmes, France
*
*Address for correspondence: F. Jollant, Douglas Mental Health University Institute, Frank B. Common Building, 6875 LaSalle Boulevard, Montréal, Québec, H4H 1R3, Canada. (Email: [email protected])
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Abstract

Background

Cognitive inhibition deficits have previously been found in suicide attempters. This study examined the neural basis for these deficits in depressed patients with and without a history of suicidal behavior.

Method

Functional magnetic resonance imaging was used to measure brain activation during the Go/No-Go response inhibition task in 25 unmedicated and depressed middle-aged suicide attempters, 22 unmedicated depressed patient controls with no personal or family history of suicidal behavior, and 27 healthy controls. Whole-brain analyses were conducted with SPM12.

Results

Suicide attempters exhibited an elevated number of commission errors relative to both control groups. However, suicide attempters did not differ from patient controls in terms of brain activation for any contrast. Analyses showed a significant association between depression and brain activation in the left inferior frontal gyrus and medial thalamus during Go v. No-Go, and in the bilateral parietal cortex and left orbitofrontal cortex during No-Go v. baseline. These regions were correlated with psychological pain, suicidal ideation and global functioning. There was no association between brain activation and personal histories of suicidal act.

Conclusions

Our study suggests that deficits in cognitive inhibition, in relation to the inferior frontal gyrus, thalamus, orbitofrontal cortex and parietal cortex, are related to the depressive state and not specifically to suicide vulnerability. We hypothesize that state-related deficits may add to trait-like cognitive impairments to facilitate suicidal acts. These different types of cognitive impairments may necessitate different therapeutic strategies for the prevention of suicide.

Keywords

Cognitive inhibitiondepressionfunctional magnetic resonance imagingGo/No-Go testsuicide
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 5 , April 2016 , pp. 933 - 944
Copyright
Copyright © Cambridge University Press 2015 

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