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Cognitive impairment, clinical course and treatment history in out-patients with bipolar affective disorder: relationship to tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

John L. Waddington ,
Katherine Brown ,
Jane O'Neill ,
Patrick McKeon  and
Anthony Kinsella
John L. Waddington*
Affiliation:
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland
Katherine Brown
Affiliation:
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland
Jane O'Neill
Affiliation:
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland
Patrick McKeon
Affiliation:
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland
Anthony Kinsella
Affiliation:
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland
*
1Address for correspondence: Dr John L. Waddington, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland.
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Synopsis

Clinical, neuropsychological and psychopharmacological characteristics were investigated for their ability to distinguish individuals with and without involuntary movements (tardive dyskinesia), among a population of 40 out-patients with bipolar affective disorder and a history of exposure to neuroleptics and lithium. Impaired performance on a test of cognitive flexibility bore the primary association with both the presence and the severity of involuntary movements. The additional relationships identified emphasized further that individual vulnerability to involuntary movements appeared to be associated not with greater duration or dosage of treatment, but with features of the bipolar illness, including number and type of affective episodes, for which that treatment was prescribed.

Type
Original Articles
Information
Psychological Medicine , Volume 19 , Issue 4 , November 1989 , pp. 897 - 902
Copyright
Copyright © Cambridge University Press 1989

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