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Chlormethiazole, sleep, and drug withdrawal
Published online by Cambridge University Press: 09 July 2009
Synopsis
The hypothesis that drug withdrawal delirium was related to a gross disturbance of sleep and a marked excess of REM sleep, suggested that drugs used to treat delirium should depress REM sleep. Chlormethiazole in doses over l g was found to be effective in depressing REM sleep and in blocking the REM sleep rebound when sodium amylobarbitone (400 mg) was stopped abruptly.
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- Copyright © Cambridge University Press 1972
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