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Chlormethiazole, sleep, and drug withdrawal

Published online by Cambridge University Press:  09 July 2009

J. I. Evans ,
S. A. Lewis  and
M. Tinker
J. I. Evans
Affiliation:
From the Sleep Laboratory, Department of Psychiatry, University of Edinburgh
S. A. Lewis
Affiliation:
From the Sleep Laboratory, Department of Psychiatry, University of Edinburgh
M. Tinker
Affiliation:
From the Sleep Laboratory, Department of Psychiatry, University of Edinburgh
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Synopsis

The hypothesis that drug withdrawal delirium was related to a gross disturbance of sleep and a marked excess of REM sleep, suggested that drugs used to treat delirium should depress REM sleep. Chlormethiazole in doses over l g was found to be effective in depressing REM sleep and in blocking the REM sleep rebound when sodium amylobarbitone (400 mg) was stopped abruptly.

Type
Research Article
Information
Psychological Medicine , Volume 2 , Issue 3 , August 1972 , pp. 239 - 247
Copyright
Copyright © Cambridge University Press 1972

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