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Childhood parental loss and alcoholism in women: a causal analysis using a twin-family design

Published online by Cambridge University Press:  09 July 2009

K. S. Kendler ,
M. C. Neale ,
C. A. Prescott ,
R. C. Kessler ,
A. C. Heath ,
L. A. Corey  and
L. J. Eaves
K. S. Kendler*
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
M. C. Neale
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
C. A. Prescott
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
R. C. Kessler
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
A. C. Heath
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
L. A. Corey
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
L. J. Eaves
Affiliation:
Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA; the Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
*
1Address for correspondence: Dr Kenneth S. Kendler, PO Box 980710, Richmond, VA 23298–0710, USA.
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Synopsis

Childhood parental loss may be an important risk factor for psychiatric illness in adulthood. While this association has been carefully examined for depression, little is known about the role of parental loss in predisposing to alcoholism. We examined an epidemiological sample of female twin pairs with the same history of continuity or disruption in parent–child relationships (N = 1018 pairs; mean age 30 years), using a range of definitions of alcoholism. Childhood parental loss through separation, but not death, substantially increased the risk in adulthood for all definitions of alcoholism. Furthermore, both paternal and maternal alcoholism substantially increased the probability of parental separation from their children. Proposing a structural equation twin-family model that incorporates childhood parental loss as a specified environmental risk factor, we examined how much of the association between childhood parental loss and alcoholism was causal (i.e. mediated by environmental factors) v. non-causal (mediated by genetic factors, with parental loss serving as an index of parental genetic susceptibility to alcoholism). Both the causal and non-causal paths were significant for all definitions of alcoholism. However, the causal–environmental pathway consistently accounted for most of the association. While a significant proportion of the association is due to non-causal genetic mechanisms, childhood parental loss (or the familial discord that precedes or follows it) is probably a direct and significant environmental risk factor for the development of alcoholism in women.

Type
Original Articles
Information
Psychological Medicine , Volume 26 , Issue 1 , January 1996 , pp. 79 - 95
Copyright
Copyright © Cambridge University Press 1996

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