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Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia

Published online by Cambridge University Press:  09 July 2009

Godfrey D. Pearlson ,
Peter V. Rabins  and
Alistair Burns
Godfrey D. Pearlson
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
Peter V. Rabins
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
Alistair Burns
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Baltimore, Maryland, USA
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Synopsis

A standardized, reliable means of assessing CT attenuation numbers in the centrum semiovale and surrounding grey matter was developed. This was applied to cranial CT scans of 60 normal controls (36 aged > 60 years), 25 elderly patients with major depression (14 of whom had the dementia syndrome of depression), and 10 patients with Alzheimer's disease (AD). Subjects received neuropsychological evaluation.

Centrum semiovale (CSO) CT attenuation numbers decreased with increasing age for both white and grey matter. White matter attenuation values best discriminated elderly controls from the three patient groups. Both white and grey matter CSO attenuation values correlated with performance on a number of cognitive tasks.

Type
Original Articles
Information
Psychological Medicine , Volume 21 , Issue 2 , May 1991 , pp. 321 - 328
Copyright
Copyright © Cambridge University Press 1991

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