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Catechol-O-methyltransferase Val158Met association with parahippocampal physiology during memory encoding in schizophrenia

Published online by Cambridge University Press:  13 December 2010

A. Di Giorgio ,
G. Caforio ,
G. Blasi ,
P. Taurisano ,
L. Fazio ,
R. Romano ,
G. Ursini ,
B. Gelao ,
L. Lo Bianco  and
A. Papazacharias
...Show all authors
A. Di Giorgio
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy Psychiatric Liaison Service, IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy Section of Neuroradiology, Department of Neuroscience, University of Catania, Italy
G. Caforio
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
G. Blasi
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
P. Taurisano
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy Section of Neuroradiology, IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy
L. Fazio
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
R. Romano
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
G. Ursini
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy Mendel Lab, IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy
B. Gelao
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
L. Lo Bianco
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
A. Papazacharias
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
L. Sinibaldi
Affiliation:
Mendel Lab, IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy
T. Popolizio
Affiliation:
Section of Neuroradiology, IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy
A. Bellomo
Affiliation:
Section of Psychiatry and Clinical Psychology, University of Foggia, Italy
A. Bertolino*
Affiliation:
Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy Section of Neuroradiology, IRCCS ‘Casa Sollievo della Sofferenza’, San Giovanni Rotondo, Italy
*
*Address for correspondence: A. Bertolino, M.D., Ph.D., Dipartimento di Scienze Neurologiche e Psichiatriche, Università degli Studi di Bari, Piazza Giulio Cesare, 11, 70124 Bari, Italy. (Email: [email protected])
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Abstract

Background

Catechol-O-methyltransferase (COMT) Val158Met has been associated with activity of the mesial temporal lobe during episodic memory and it may weakly increase risk for schizophrenia. However, how this variant affects parahippocampal and hippocampal physiology when dopamine transmission is perturbed is unclear. The aim of the present study was to compare the effects of the COMT Val158Met genotype on parahippocampal and hippocampal physiology during encoding of recognition memory in patients with schizophrenia and in healthy subjects.

Method

Using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI), we studied 28 patients with schizophrenia and 33 healthy subjects matched for a series of sociodemographic and genetic variables while they performed a recognition memory task.

Results

We found that healthy subjects had greater parahippocampal and hippocampal activity during memory encoding compared to patients with schizophrenia. We also found different activity of the parahippocampal region between healthy subjects and patients with schizophrenia as a function of the COMT genotype, in that the predicted COMT Met allele dose effect had an opposite direction in controls and patients.

Conclusions

Our results demonstrate a COMT Val158Met genotype by diagnosis interaction in parahippocampal activity during memory encoding and may suggest that modulation of dopamine signaling interacts with other disease-related processes in determining the phenotype of parahippocampal physiology in schizophrenia.

Keywords

COMTfMRImemory encodingschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 8 , August 2011 , pp. 1721 - 1731
Copyright
Copyright © Cambridge University Press 2010

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