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Cannabis use in the last year in a US national sample of twin and sibling pairs

Published online by Cambridge University Press:  07 May 2002

K. S. KENDLER ,
M. C. NEALE ,
L. M. THORNTON ,
S. H. AGGEN ,
S. E. GILMAN  and
R. C. KESSLER
K. S. KENDLER
Affiliation:
From the Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA; Department of Health and Social Behavior Harvard School of Public Health, and Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
M. C. NEALE
Affiliation:
From the Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA; Department of Health and Social Behavior Harvard School of Public Health, and Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
L. M. THORNTON
Affiliation:
From the Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA; Department of Health and Social Behavior Harvard School of Public Health, and Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
S. H. AGGEN
Affiliation:
From the Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA; Department of Health and Social Behavior Harvard School of Public Health, and Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
S. E. GILMAN
Affiliation:
From the Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA; Department of Health and Social Behavior Harvard School of Public Health, and Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
R. C. KESSLER
Affiliation:
From the Department of Psychiatry and Department of Human Genetics, Medical College of Virginia/Virginia Commonwealth University and Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA; Department of Health and Social Behavior Harvard School of Public Health, and Department of Health Care Policy, Harvard Medical School, Boston, MA, USA
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Abstract

Background. Three prior population-based twin studies, none of which was nationally representative, suggested that both genetic and familial–environmental factors contribute to family resemblance for lifetime cannabis use. We seek to replicate these results in a US national probability sample of twin and sibling pairs examining only last year cannabis use.

Methods. Cannabis use in the last year was assessed by self-report questionnaire. Biometrical twin analyses were performed.

Results. Twin and sibling resemblance for last-year cannabis use was substantial, and much higher in monozygotic pairs than in dizygotic and sibling pairs, where levels of resemblance were similar. Modeling suggested that sibling resemblance was due to genetic factors – with a heritability of at least 60% – and probably family environmental factors. No evidence was found that cannabis use was influenced by a special twin environment.

Conclusions. Consistent with prior studies, use of cannabis is substantially influenced by genetic factors but family–environment is also possibly of importance.

Type
Brief Communication
Information
Psychological Medicine , Volume 32 , Issue 3 , April 2002 , pp. 551 - 554
Copyright
© 2002 Cambridge University Press

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