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Cannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence

Published online by Cambridge University Press:  09 December 2009

M. Harley ,
I. Kelleher ,
M. Clarke ,
F. Lynch ,
L. Arseneault ,
D. Connor ,
C. Fitzpatrick  and
M. Cannon
M. Harley
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland Department of Child and Adolescent Mental Health, Mater Misericordiae University Hospital, The Children's University Hospital Temple Street, and University College Dublin, Dublin, Ireland
I. Kelleher
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland
M. Clarke
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland
F. Lynch
Affiliation:
Department of Child and Adolescent Mental Health, Mater Misericordiae University Hospital, The Children's University Hospital Temple Street, and University College Dublin, Dublin, Ireland
L. Arseneault
Affiliation:
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, UK
D. Connor
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland
C. Fitzpatrick
Affiliation:
Department of Child and Adolescent Mental Health, Mater Misericordiae University Hospital, The Children's University Hospital Temple Street, and University College Dublin, Dublin, Ireland
M. Cannon*
Affiliation:
Department of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland
*
*Address for correspondence: Professor M. Cannon, Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. (Email: [email protected])
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Abstract

Background

Adolescent cannabis use has been shown in many studies to increase the risk of later psychosis. Childhood trauma is associated with both substance misuse and risk for psychosis. In this study our aim was to investigate whether there is a significant interaction between cannabis use and childhood trauma in increasing the risk for experiencing psychotic symptoms during adolescence.

Method

Psychiatric interviews using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) semi-structured instrument were carried out with 211 adolescents aged between 12 and 15 years and their parents as part of a population-based study. The interview enquired about early traumatic events, cannabis use and psychiatric symptoms in adolescence.

Results

In separate analyses both cannabis use and childhood trauma were significantly associated with risk of experiencing psychotic symptoms. However, the presence of both childhood trauma and early cannabis use significantly increased the risk for psychotic symptoms beyond the risk posed by either risk factor alone, indicating that there was a greater than additive interaction between childhood trauma and cannabis use.

Conclusion

Our finding of a greater than additive interaction between childhood trauma and cannabis use may have implications for the identification of individuals at high risk of experiencing psychotic symptoms. For example, measures to actively discourage or intensively treat cannabis use in children and adolescents who have experienced abuse may help to prevent the development of psychosis in this vulnerable group. Our findings require replication in larger samples to confirm this interaction effect.

Keywords

Additive interactionadolescencecannabischildhood traumapsychotic symptoms
Type
Original Articles
Information
Psychological Medicine , Volume 40 , Issue 10 , October 2010 , pp. 1627 - 1634
Copyright
Copyright © Cambridge University Press 2009

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