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Calcium metabolism and mental disorder1

Published online by Cambridge University Press:  09 July 2009

J. L. Crammer
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This is an uncertain, neglected and misunderstood corner of organic psychiatry. Calcium disturbances are clinically the concern of physicians interested in bone diseases, in malabsorption or nutritional deficiencies, and opinions vary on whether such illnesses are accompanied by emotional and behavioural disorder: at least psychiatrists are not usually called in. Parathyroid disease is generally granted to have frequent psychiatric accompaniments (e.g. see Granville-Grossman, 1971) but is very rare in the psychiatric clinic, and possibly under-diagnosed there. Laboratory aids tend to be underused or inadequately applied. Total plasma calcium as a screening test cannot be understood without at least a plasma protein measurement as well; but serum phosphate, parathormone and plasma 1, 25-dihydroxycholecalciferol levels, urinary calcium and magnesium, and Ca45, may all have roles in fuller investigation (Nordin, 1976).

Type
Editorial
Information
Psychological Medicine , Volume 7 , Issue 4 , November 1977 , pp. 557 - 560
Copyright
Copyright © Cambridge University Press 1977

References

Bjørum, N., Hornum, I., Mellerup, E. T., Plenge, P. K. & Rafaclsen, O. J. (1975). Lithium, calcium and phosphate. Lancet i, 1243.CrossRefGoogle Scholar
Boonstra, C. E. & Jackson, C. E. (1965). Hyperparathyroidism detected by routine serum calcium analysis. Annals of Internal Medicine 63, 468–474.CrossRefGoogle ScholarPubMed
British Medical Journal (1968). Editorial: Calcium in psychiatry, ii, 5.Google Scholar
Christie-Brown, J. R. W. (1968). Mood changes following parathyroidectomy. Proceedings of the Royal Society of Medicine 61, 1121–1123.CrossRefGoogle ScholarPubMed
Cooper, A. F. & Schapira, K. (1973). Case report: depression, catatonic stupor and EEG changes in hyperparathyroidism. Psychological Medicine 3, 509–515.CrossRefGoogle ScholarPubMed
Cuthbert, A. W. (1970). Calcium and Cellular Function. Macmillan: London.CrossRefGoogle Scholar
Damas Mora, J., Grant, L., Kenyon, P., Patel, M. K. & Jenner, F. A. (1976). Respiratory ventilation and carbon dioxide levels in syndromes of depression. British Journal of Psychiatry 129, 457–464.CrossRefGoogle Scholar
Documenta Geigy (1962). Scientific Tables 6th edn, p. 516, Manchester.Google Scholar
Edwards, G. A. & Daum, S. M. (1959). Increased spinal fluid protein in hyperparathyroidism and other hypercalcaemic states. A.M.A. Archives of Internal Medicine 104, 29–36.CrossRefGoogle Scholar
Faragulla, F. F. & Flach, F. F. (1970). Studies of mineral metabolism in mental depression. 1. The effects of imipramine and ECT on calcium balance and kinetics. Journal of Nervous and Mental Disease 151, 121–129.Google Scholar
Fourman, P., Davis, R. H., Jones, K. H., Morgan, D. B. & Smith, J. W. G. (1963). Parathyroid insufficiency after thyroidectomy. Review of 46 patients with a study of the effects of hypocalcaemia on the electroencephalogram. British Journal of Surgery 50, 608–619.CrossRefGoogle ScholarPubMed
Gatewood, J. W., Organ, C. H. & Mead, B. T. (1975). Mental changes associated with hyperparathyroidism. American Journal of Psychiatry 132, 129–132.Google ScholarPubMed
Granville-Grossman, K. (1971). Recent Advances in Clinical Psychiatry, pp. 222–231. Churchill Livingstone: London.Google Scholar
Herbert, F. K. (1933). The total and diffusible calcium of serum and the calcium of CSF in human cases of hypo and hyper-calcaemia. Biochemical Journal 27, 1978–1991.CrossRefGoogle Scholar
Hockaday, T. D. R., Keynes, W. M. & McKenzie, J. K. (1966). Catatonic stupor in elderly women with hyper-parathyroidism. British Medical Journal i, 85–87.CrossRefGoogle Scholar
Kakunaga, T., Kaneto, H. & Hano, K. (1966). Pharmacological studies on analgesics. VII: significance of the calcium ion in morphine analgesia. Journal of Pharmacology and Experimental Therapeutics 153, 134–141.Google ScholarPubMed
Kurtz, D. (1976). The EEG in parathyroid dysfunction. In Handbook of Electroencephalography and Clinical Neurophysiology (ed. Rémond, A.), pp. 77–87. Elsevier: Amsterdam.Google Scholar
Labhardt, A. (1974). Clinical Endocrinology: Theory and Practice, pp. 845–946. Springer Verlag: Berlin.CrossRefGoogle Scholar
Manery, J. F. (1969). Calcium and membranes. In Mineral Metabolism, vol. III, Calcium Physiology (ed. Comar, C. L. and Bronner, F.), pp. 405–452. Academic Press: New York.CrossRefGoogle Scholar
Nordin, B. E. C. (1976). Calcium, Phosphate and Magnesium Metabolism. Churchill Livingstone: London.Google Scholar
Nordin, B. E. C. & Fraser, R. (1956). A calcium infusion test. Lancet i, 823–826.CrossRefGoogle Scholar
Northover, B. J. (1972). The effects of indomethacin on calcium, sodium, potassium and magnesium fluxes in various tissues of the guinea-pig. British Journal of Pharmacology 45, 651–659.CrossRefGoogle ScholarPubMed
Oppelt, W. W., Owens, E. S. & Roll, D. P. (1963). Calcium exchange between blood and CSF. Life Sciences no. 8, 599–605.CrossRefGoogle Scholar
Sammachson, J., Kabakow, B., Spencer, H. & Laszlo, D. (1959). Comparative passage of Ca45 and Sr85 from plasma into CSF in man. Proceedings of the Society for Experimental Biology and Medicine 102, 287–290.CrossRefGoogle Scholar
Schain, R. J. (1964). Cerebrospinal fluid and serum cation levels. Archives of Neurology 11, 330–333.CrossRefGoogle ScholarPubMed
Wallach, S., Bellavia, J. V., Schorr, J. & Reizenstein, D. L. (1964). Tissue distribution of electrolytes, Ca47 and Mg28 in acute hypercalcaemia. American Journal of Physiology 207, 553.CrossRefGoogle Scholar
Watson, L. (1968). Clinical aspects of hyperparathyroidism. Proceedings of the Royal Society of Medicine 61, 1123.CrossRefGoogle ScholarPubMed
Williams, R. H. (1974). Textbook of Endocrinology, 5th edn, pp. 660–773. Saunders: Philadelphia.Google Scholar