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Brain functional changes in first-degree relatives of patients with bipolar disorder: evidence for default mode network dysfunction

Published online by Cambridge University Press:  23 June 2016

S. Alonso-Lana ,
M. Valentí ,
A. Romaguera ,
C. Sarri ,
S. Sarró ,
A. Rodríguez-Martínez ,
J. M. Goikolea ,
B. L. Amann ,
T. Maristany  and
R. Salvador
...Show all authors
S. Alonso-Lana*
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
M. Valentí
Affiliation:
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
A. Romaguera
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain
C. Sarri
Affiliation:
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain
S. Sarró
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
A. Rodríguez-Martínez
Affiliation:
Parc de Salut Mar, Barcelona, Spain
J. M. Goikolea
Affiliation:
Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
B. L. Amann
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
T. Maristany
Affiliation:
Hospital Sant Joan de Déu Infantil, Barcelona, Spain
R. Salvador
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
E. Vieta
Affiliation:
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Spain
P. J. McKenna
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
E. Pomarol-Clotet
Affiliation:
FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain
*
*Address for correspondence: S. Alonso-Lana, FIDMAG Germanes Hospitalàries Research Foundation, C/Dr Antoni Pujades, 38, E-08830 Sant Boi de Llobregat, Barcelona, Spain. (Email: [email protected])
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Abstract

Background

Relatively few studies have investigated whether relatives of patients with bipolar disorder show brain functional changes, and these have focused on activation changes. Failure of de-activation during cognitive task performance is also seen in the disorder and may have trait-like characteristics since it has been found in euthymia.

Method

A total of 20 euthymic patients with bipolar disorder, 20 of their unaffected siblings and 40 healthy controls underwent functional magnetic resonance imaging during performance of the n-back working memory task. An analysis of variance (ANOVA) was fitted to individual whole-brain maps from each set of patient–relative–matched pair of controls. Clusters of significant difference among the groups were used as regions of interest to compare mean activations/de-activations between them.

Results

A single cluster of significant difference among the three groups was found in the whole-brain ANOVA. This was located in the medial prefrontal cortex, a region of task-related de-activation in the healthy controls. Both the patients and their siblings showed significantly reduced de-activation compared with the healthy controls in this region, but the failure was less marked in the relatives.

Conclusions

Failure to de-activate the medial prefrontal cortex in both euthymic bipolar patients and their unaffected siblings adds to evidence for default mode network dysfunction in the disorder, and suggests that it may act as a trait marker.

Keywords

Bipolar disorderdefault mode networkeuthymiafirst-degree relativesfunctional magnetic resonance imaging
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 12 , September 2016 , pp. 2513 - 2521
Copyright
Copyright © Cambridge University Press 2016 

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