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Blood barbiturate levels in a patient dependent upon amylobarbitone sodium

Published online by Cambridge University Press:  09 July 2009

J. P. Watson  and
M. D. Radford
J. P. Watson
Affiliation:
Belhlem Royal and Maudsley Hospitals and the Institute of Psychiatry, London
M. D. Radford
Affiliation:
Belhlem Royal and Maudsley Hospitals and the Institute of Psychiatry, London
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Summary

In a barbiturate dependent patient, the blood barbiturate was less than 0·2 mg% two and a half hours after an oral dose of 200 mg amylobarbitone sodium. Amylobarbitone was withdrawn, and the patient was maintained on phenobarbitone, with a blood barbiturate level that remained at about 4·0 mg% over several weeks. Themost likelyexplanation of the findings is that the oxidation of amylobarbitone, but not phenobarbitone, is accelerated in patients dependent on the former drug.

Type
Research Article
Information
Psychological Medicine , Volume 1 , Issue 2 , February 1971 , pp. 178 - 180
Copyright
Copyright © Cambridge University Press 1971

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References

REFERENCES

Brodie, B. B. (1956). Pathways of drug metabolism. Journal of Pharmacy and Pharmacology, 8, 1–17.CrossRefGoogle ScholarPubMed
Broughton, P. M. G. (1956). A rapid ultraviolet spectrophotometric method for the detection, estimation and identification of barbiturates in biological material. Biochemical Journal, 63, 207–213.CrossRefGoogle ScholarPubMed
Burns, J. J., and Conney, A. H. (1965). Enzyme stimulation and inhibition in the metabolism of drugs. Proceedings of the Royal Society of Medicine, 58, 955–960.CrossRefGoogle ScholarPubMed
Conney, A. H., Schneidman, K., Jacobson, M., and Kuntzman, R. (1965). Drug-induced changes in steroid metabolism. Annals of the New York Academy of Sciences, 123, 98–109.CrossRefGoogle ScholarPubMed
Ebert, A. G., Yim, G. K. W., and Miya, T. S. (1964). Distribution and metabolism of barbital-C in tolerant and nontolerant rats. Biochemical Pharmacology. 13, 1267–1274.CrossRefGoogle ScholarPubMed
Mark, L C. (1965). Metabolism of barbiturates in man. Clinical Pharmacology and Therapeutics, 4, 504–530.CrossRefGoogle Scholar
Remmer, H. (1962). Drug tolerance. In CIBA Foundation Symposium on Enzymes and Drug Action, pp. 276–298. Edited by Mongar, J. L. and De Rueck, A. V. S.. Churchill: London.CrossRefGoogle Scholar
Remmer, H. (1969). Tolerance to barbiturates by increased breakdown. In Scientific Basis of Drug Dependence, p. 111 III). Edited by Steinberg, H.. Churchill: London.Google Scholar
Sjögren, J., Sölvell, L., and Karlsson, l. (1965). Studies on the absorption rate of barbiturates in man. Acta Medica Scandinavica, 178, 553–559.CrossRefGoogle ScholarPubMed