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Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder

Published online by Cambridge University Press:  12 November 2014

S. Park ,
J.-M. Lee ,
J.-W. Kim ,
J. H. Cheong ,
H. J. Yun ,
Y.-C. Hong ,
Y. Kim ,
D. H. Han ,
H.J. Yoo  and
M.-S. Shin
...Show all authors
S. Park
Affiliation:
Department of Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, Republic of Korea
J.-M. Lee
Affiliation:
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea
J.-W. Kim
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea College of Medicine and Behavioral Medicine Institute, Seoul National University, Seoul, Republic of Korea
J. H. Cheong
Affiliation:
Uimyung Research Institute for Neuroscience, Sahmyook University, Seoul, Republic of Korea
H. J. Yun
Affiliation:
Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea
Y.-C. Hong
Affiliation:
Department of Preventive Medicine, Seoul National University College of Medicine and Institute of Environmental Medicine, Seoul, Republic of Korea
Y. Kim
Affiliation:
Department of Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, Republic of Korea
D. H. Han
Affiliation:
Department of Psychiatry, Chung Ang University, College of Medicine, Seoul, Republic of Korea
H.J. Yoo
Affiliation:
College of Medicine and Behavioral Medicine Institute, Seoul National University, Seoul, Republic of Korea Department of Psychiatry, Seoul National University Bung dang Hospital, Seongnam, Republic of Korea
M.-S. Shin
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea College of Medicine and Behavioral Medicine Institute, Seoul National University, Seoul, Republic of Korea
S.-C. Cho
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea College of Medicine and Behavioral Medicine Institute, Seoul National University, Seoul, Republic of Korea
B.-N. Kim*
Affiliation:
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea College of Medicine and Behavioral Medicine Institute, Seoul National University, Seoul, Republic of Korea
*
*Address for correspondence: Dr B.-N. Kim, Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University, College of Medicine, College of Medicine, 101 Daehakro, Chongro-Gu, Seoul, South Korea. (Email: [email protected])
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Abstract

Background.

Previous studies have implicated the relationship between environmental phthalate exposure and attention deficit hyperactivity disorder (ADHD) symptoms of childhood, but no studies have been conducted in children who have a confirmed diagnosis of ADHD obtained through meticulous diagnostic testing. We aimed to determine whether phthalate metabolites in urine would be higher in children with ADHD than in those without ADHD and would correlate with symptom severity and cortical thickness in ADHD children.

Method.

A cross-sectional examination of urine phthalate metabolite concentrations was performed; scores for ADHD symptoms, externalizing problems, and continuous performance tests were obtained from 180 children with ADHD, and brain-imaging data were obtained from 115 participants. For the control group, children without ADHD (N = 438) were recruited. Correlations between phthalate metabolite concentrations and clinical measures and brain cortical thickness were investigated.

Results.

Concentrations of phthalate metabolites, particularly the di(2-ethylhexyl) phthalate (DEHP) metabolite, were significantly higher in boys with ADHD than in boys without ADHD. Concentrations of the di-n-butyl phthalate (DBP) metabolite were significantly higher in the combined or hyperactive-impulsive subtypes compared to the inattentive subtype, and the metabolite was positively correlated with the severity of externalizing symptoms. Concentrations of the DEHP metabolite were negatively correlated with cortical thickness in the right middle and superior temporal gyri.

Conclusions.

The results of this study suggest an association between phthalate concentrations and both the diagnosis and symptom severity of ADHD. Imaging findings suggest a negative impact of phthalates on regional cortical maturation in children with ADHD.

Keywords

Attention-deficit hyperactivity disordercortical thicknessneuropsychologyphthalate
Type
Original Articles
Information
Psychological Medicine , Volume 45 , Issue 8 , June 2015 , pp. 1601 - 1612
Copyright
Copyright © Cambridge University Press 2014 

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