Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-23T00:55:30.047Z Has data issue: false hasContentIssue false
  • English
  • Français

Anhedonia in chronic pain and prescription opioid misuse

Published online by Cambridge University Press:  19 August 2019

Eric L. Garland ,
Martin Trøstheim ,
Marie Eikemo ,
Gernot Ernst  and
Siri Leknes
Eric L. Garland*
Affiliation:
Center on Mindfulness and Integrative Health Intervention Development, University of Utah, Salt Lake City, UT, USA College of Social Work, University of Utah, Salt Lake City, UT, USA
Martin Trøstheim
Affiliation:
Department of Psychology, University of Oslo, Norway
Marie Eikemo
Affiliation:
Department of Psychology, University of Oslo, Norway
Gernot Ernst
Affiliation:
Department of Psychology, University of Oslo, Norway Kongsberg Hospital, Norway
Siri Leknes
Affiliation:
Department of Psychology, University of Oslo, Norway
*
Author for correspondence: Eric L. Garland, E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Both acute and chronic pain can disrupt reward processing. Moreover, prolonged prescription opioid use and depressed mood are common in chronic pain samples. Despite the prevalence of these risk factors for anhedonia, little is known about anhedonia in chronic pain populations.

Methods

We conducted a large-scale, systematic study of anhedonia in chronic pain, focusing on its relationship with opioid use/misuse, pain severity, and depression. Chronic pain patients across four distinct samples (N = 488) completed the Snaith–Hamilton Pleasure Scale (SHAPS), measures of opioid use, pain severity and depression, as well as the Current Opioid Misuse Measure (COMM). We used a meta-analytic approach to determine reference levels of anhedonia in healthy samples spanning a variety of countries and diverse age groups, extracting SHAPS scores from 58 published studies totaling 2664 psychiatrically healthy participants.

Results

Compared to healthy samples, chronic pain patients showed higher levels of anhedonia, with ~25% of patients scoring above the standard anhedonia cut-off. This difference was not primarily driven by depression levels, which explained less than 25% of variance in anhedonia scores. Neither opioid use duration, dose, nor pain severity alone was significantly associated with anhedonia. Yet, there was a clear effect of opioid misuse, with opioid misusers (COMM ⩾13) reporting greater anhedonia than non-misusers. Opioid misuse remained a significant predictor of anhedonia even after controlling for pain severity, depression and opioid dose.

Conclusions

Study results suggest that both chronic pain and opioid misuse contribute to anhedonia, which may, in turn, drive further pain and misuse.

Keywords

addictiondepressionhedonicopioidpositive affectreward.
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 12 , September 2020 , pp. 1977 - 1988
Copyright
Copyright © Cambridge University Press 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Admon, R and Pizzagalli, DA (2015) Corticostriatal pathways contribute to the natural time course of positive mood. Nature Communications 6, 10065.CrossRefGoogle ScholarPubMed
Al Aïn, S, Carré, A, Fantini-Hauwel, C, Baudouin, J-Y and Besche-Richard, C (2013) What is the emotional core of the multidimensional Machiavellian personality trait? Frontiers in Psychology 4, 454.CrossRefGoogle ScholarPubMed
Ameli, R, Luckenbaugh, DA, Gould, NF, Holmes, MK, Lally, N, Ballard, ED and Zarate, CA Jr (2014) SHAPS-C: the Snaith-Hamilton pleasure scale modified for clinician administration. PeerJ 2, e429.CrossRefGoogle ScholarPubMed
Ang, Y-S, Lockwood, P, Apps, MAJ, Muhammed, K and Husain, M (2017) Distinct subtypes of apathy revealed by the apathy motivation index. PLoS One 12, e0169938.CrossRefGoogle ScholarPubMed
Arout, CA, Edens, E, Petrakis, IL and Sofuoglu, M (2015) Targeting opioid-induced hyperalgesia in clinical treatment: neurobiological considerations. CNS Drugs 29, 465–486.CrossRefGoogle ScholarPubMed
Auerbach, RP, Pisoni, A, Bondy, E, Kumar, P, Stewart, JG, Yendiki, A and Pizzagalli, DA (2017) Neuroanatomical prediction of anhedonia in adolescents. Neuropsychopharmacology 42, 2087–2095.CrossRefGoogle ScholarPubMed
Baliki, MN, Geha, PY, Fields, HL and Apkarian, AV (2010) Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron 66, 149–160.CrossRefGoogle ScholarPubMed
Barch, DM, Treadway, MT and Schoen, N (2014) Effort, anhedonia, and function in schizophrenia: reduced effort allocation predicts amotivation and functional impairment. Journal of Abnormal Psychology 123, 387–397.CrossRefGoogle ScholarPubMed
Buchel, C, Miedl, S and Sprenger, C (2018) Hedonic processing in humans is mediated by an opioidergic mechanism in a mesocorticolimbic system. eLife 7, e39648.CrossRefGoogle Scholar
Butler, SF, Budman, SH, Fernandez, KC, Houle, B, Benoit, C, Katz, N and Jamison, RN (2007) Development and validation of the Current Opioid Misuse Measure. Pain 130, 144–156.CrossRefGoogle ScholarPubMed
Carpinelli, L, Bucci, C, Santonicola, A, Zingone, F, Ciacci, C and Iovino, P (2019) Anhedonia in irritable bowel syndrome and in inflammatory bowel diseases and its relationship with abdominal pain. Neurogastroenterology and Motility, e13531.CrossRefGoogle ScholarPubMed
Chase, HW, Fournier, JC, Bertocci, MA, Greenberg, T, Aslam, H, Stiffler, R, Lockovich, J, Graur, S, Bebko, G, Forbes, EE and Phillips, ML (2017) A pathway linking reward circuitry, impulsive sensation-seeking and risky decision-making in young adults: identifying neural markers for new interventions. Translational Psychiatry 7, e1096.CrossRefGoogle ScholarPubMed
Chelnokova, O, Laeng, B, Eikemo, M, Riegels, J, Løseth, G, Maurud, H, Willoch, F and Leknes, S (2014) Rewards of beauty: the opioid system mediates social motivation in humans. Molecular Psychiatry 19, 746–747.CrossRefGoogle ScholarPubMed
Chou, R, Fanciullo, GJ, Fine, PG, Adler, JA, Ballantyne, JC, Davies, P, Donovan, MI, Fishbain, DA, Foley, KM, Fudin, J, Gilson, AM, Kelter, A, Mauskop, A, O'Connor, PG, Passik, SD, Pasternak, GW, Portenoy, RK, Rich, BA, Roberts, RG, Todd, KH and Miaskowski, C (2009) Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. The Journal of Pain 10, 113–130.CrossRefGoogle ScholarPubMed
Christie, MJ (2008) Cellular neuroadaptations to chronic opioids: tolerance, withdrawal and addiction. British Journal of Pharmacology 154, 384–396.CrossRefGoogle ScholarPubMed
Chung, YS and Barch, D (2015) Anhedonia is associated with reduced incentive cue related activation in the basal ganglia. Cognitive, Affective, & Behavioral Neuroscience 15, 749–767.CrossRefGoogle ScholarPubMed
Crombez, G, Eccleston, C, Baeyens, F and Eelen, P (1996) The disruptive nature of pain: an experimental investigation. Behaviour Research and Therapy 34, 911–918.CrossRefGoogle Scholar
Culbreth, AJ, Gold, JM, Cools, R and Barch, DM (2016 a) Impaired activation in cognitive control regions predicts reversal learning in schizophrenia. Schizophrenia Bulletin 42, 484–493.CrossRefGoogle Scholar
Culbreth, AJ, Westbrook, A, Daw, ND, Botvinick, M and Barch, DM (2016 b) Reduced model-based decision-making in schizophrenia. Journal of Abnormal Psychology 125, 777–787.CrossRefGoogle Scholar
Dean, Z, Horndasch, S, Giannopoulos, P and McCabe, C (2016) Enhanced neural response to anticipation, effort and consummation of reward and aversion during bupropion treatment. Psychological Medicine 46, 2263–2274.CrossRefGoogle ScholarPubMed
DerSimonian, R and Laird, N (1986) Meta-analysis in clinical trials. Controlled Clinical Trials 7, 177–188.CrossRefGoogle ScholarPubMed
Dillon, DG, Wiecki, T, Pechtel, P, Webb, C, Goer, F, Murray, L, Trivedi, M, Fava, M, McGrath, PJ, Weissman, M, Parsey, R, Kurian, B, Adams, P, Carmody, T, Weyandt, S, Shores-Wilson, K, Toups, M, McInnis, M, Oquendo, MA, Cusin, C, Deldin, P, Bruder, G and Pizzagalli, DA (2015) A computational analysis of flanker interference in depression. Psychological Medicine 45, 2333–2344.CrossRefGoogle ScholarPubMed
Drijgers, RL, Verhey, FRJ, Tissingh, G, van Domburg, PHMF, Aalten, P and Leentjens, AFG (2012) The role of the dopaminergic system in mood, motivation and cognition in Parkinson's disease: a double blind randomized placebo-controlled experimental challenge with pramipexole and methylphenidate. Journal of the Neurological Sciences 320, 121–126.CrossRefGoogle ScholarPubMed
Eccleston, C and Crombez, G (1999) Pain demands attention: a cognitive-affective model of the interruptive function of pain. Psychological Bulletin 125, 356–366.CrossRefGoogle ScholarPubMed
Eikemo, M, Løseth, GE, Johnstone, T, Gjerstad, J, Willoch, F and Leknes, S (2016) Sweet taste pleasantness is modulated by morphine and naltrexone. Psychopharmacology, 1–13.Google ScholarPubMed
Eikemo, M, Lobmaier, PP, Pedersen, ML, Kunoe, N, Matziorinis, AM, Leknes, S and Sarfi, M (2019) Intact responses to non-drug rewards in long-term opioid maintenance treatment. Neuropsychopharmacology 44, 1456–1463.CrossRefGoogle ScholarPubMed
Eisenstein, SA, Bogdan, R, Chen, L, Moerlein, SM, Black, KJ, Perlmutter, JS, Hershey, T and Barch, DM (2017) Preliminary evidence that negative symptom severity relates to multilocus genetic profile for dopamine signaling capacity and D2 receptor binding in healthy controls and in schizophrenia. Journal of Psychiatric Research 86, 9–17.CrossRefGoogle Scholar
Elvemo, NA, Landrø, NI, Borchgrevink, PC and Håberg, AK (2015). Reward responsiveness in patients with chronic pain. European Journal of Pain, n/a–n/a.CrossRefGoogle ScholarPubMed
Fervaha, G, Graff-Guerrero, A, Zakzanis, KK, Foussias, G, Agid, O and Remington, G (2013) Incentive motivation deficits in schizophrenia reflect effort computation impairments during cost-benefit decision-making. Journal of Psychiatric Research 47, 1590–1596.CrossRefGoogle ScholarPubMed
Franken, IHA, Rassin, E and Muris, P (2007) The assessment of anhedonia in clinical and non-clinical populations: further validation of the Snaith–Hamilton Pleasure Scale (SHAPS). Journal of Affective Disorders 99, 83–89.CrossRefGoogle Scholar
Gadeikis, D, Bos, N, Schweizer, S, Murphy, F and Dunn, B (2017) Engaging in an experiential processing mode increases positive emotional response during recall of pleasant autobiographical memories. Behaviour Research and Therapy 92, 68–76.CrossRefGoogle Scholar
Garfield, JBB, Cotton, SM, Allen, NB, Cheetham, A, Kras, M, Yücel, M and Lubman, DI (2017) Evidence that anhedonia is a symptom of opioid dependence associated with recent use. Drug and Alcohol Dependence 177, 29–38.CrossRefGoogle ScholarPubMed
Garland, EL, Froeliger, B, Zeidan, F, Partin, K and Howard, MO (2013) The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways. Neuroscience and Biobehavioral Reviews 37, 2597–2607.CrossRefGoogle ScholarPubMed
Garland, EL, Froeliger, B and Howard, MO (2014 a) Effects of mindfulness-oriented recovery enhancement on reward responsiveness and opioid cue-reactivity. Psychopharmacology 231, 3229–3238.CrossRefGoogle ScholarPubMed
Garland, EL, Manusov, EG, Froeliger, B, Kelly, A, Williams, JM and Howard, MO (2014 b) Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: results from an early-stage randomized controlled trial. Journal of Consulting and Clinical Psychology 82, 448.CrossRefGoogle ScholarPubMed
Garland, EL, Froeliger, B and Howard, MO (2015 b) Neurophysiological evidence for remediation of reward processing deficits in chronic pain and opioid misuse following treatment with mindfulness-oriented recovery enhancement: exploratory ERP findings from a pilot RCT. Journal of Behavioral Medicine 38, 327–336.CrossRefGoogle ScholarPubMed
Garland, EL, Froeliger, B and Howard, MO (2015 a) Allostatic dysregulation of natural reward processing in prescription opioid misuse: autonomic and attentional evidence. Biological Psychology 105, 124–129.CrossRefGoogle ScholarPubMed
Garland, EL, Bryan, CJ, Nakamura, Y, Froeliger, B and Howard, MO (2017) Deficits in autonomic indices of emotion regulation and reward processing associated with prescription opioid use and misuse. Psychopharmacology (Berl) 234, 621–629.CrossRefGoogle ScholarPubMed
Garland, EL, Hanley, AW, Riquino, MR, Reese, SE, Baker, AK, Salas, K, Yack, BP, Bedford, CE, Bryan, MA, Atchley, RM, Nakamura, Y, Froeliger, B and Howard, MO (2019) Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: a randomized controlled trial. Journal of Consulting and Clinical Psychology.CrossRefGoogle ScholarPubMed
Geha, P, deAraujo, I, Green, B and Small, DM (2014) Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 155, 712–722.CrossRefGoogle ScholarPubMed
Godlewska, BR, Masaki, C, Sharpley, AL, Cowen, PJ and Emir, UE (2018) Brain glutamate in medication-free depressed patients: a proton MRS study at 7 Tesla. Psychological Medicine 48, 1731–1737.CrossRefGoogle ScholarPubMed
Gradin, VB, Pérez, A, MacFarlane, JA, Cavin, I, Waiter, G, Engelmann, J, Dritschel, B, Pomi, A, Matthews, K and Steele, JD (2015) Abnormal brain responses to social fairness in depression: an fMRI study using the Ultimatum Game. Psychological Medicine 45, 1241–1251.CrossRefGoogle ScholarPubMed
Greenberg, T, Chase, HW, Almeida, JR, Stiffler, R, Zevallos, CR, Aslam, HA, Deckersbach, T, Weyandt, S, Cooper, C, Toups, M, Carmody, T, Kurian, B, Peltier, S, Adams, P, McInnis, MG, Oquendo, MA, McGrath, PJ, Fava, M, Weissman, M, Parsey, R, Trivedi, MH and Phillips, ML (2015) Moderation of the relationship between reward expectancy and prediction error-related ventral striatal reactivity by anhedonia in unmedicated major depressive disorder: findings from the EMBARC Study. American Journal of Psychiatry 172, 881–891.CrossRefGoogle ScholarPubMed
Han, S (2017) Measuring and modifying information bias in depression. MS thesis. University of Oxford. Oxford. Available at: https://ora.ox.ac.uk/objects/uuid:3f2d2aa6-83ee-4e2e-be9f-fc9192f561fb (Accessed: 30 November 2018).Google Scholar
Harris, RE, Clauw, DJ, Scott, DJ, McLean, SA, Gracely, RH and Zubieta, J-K (2007) Decreased central mu-opioid receptor availability in fibromyalgia. The Journal of Neuroscience 27, 10000–10006.CrossRefGoogle ScholarPubMed
Higgins, JPT, Thompson, SG, Deeks, JJ and Altman, DG (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557–560.CrossRefGoogle ScholarPubMed
Horndasch, S, O'Keefe, S, Lamond, A, Brown, K and McCabe, C (2016) Increased anticipatory but decreased consummatory brain responses to food in sisters of anorexia nervosa patients. BJPsych Open 2, 255–261.CrossRefGoogle ScholarPubMed
Huhn, AS, Meyer, RE, Harris, JD, Ayaz, H, Deneke, E, Stankoski, DM and Bunce, SC (2016) Evidence of anhedonia and differential reward processing in prefrontal cortex among post-withdrawal patients with prescription opiate dependence. Brain Research Bulletin 123, 102–109.CrossRefGoogle ScholarPubMed
Huneke, NTM, Walsh, AEL, Brown, R, Browning, M and Harmer, CJ (2017) No evidence for an acute placebo effect on emotional processing in healthy volunteers. Journal of Psychopharmacology 31, 1578–1587.CrossRefGoogle ScholarPubMed
Kirkpatrick, MG, Goldenson, NI, Kapadia, N, Kahler, CW, de Wit, H, Swift, RM, McGeary, JE, Sussman, S and Leventhal, AM (2016) Emotional traits predict individual differences in amphetamine-induced positive mood in healthy volunteers. Psychopharmacology 233, 89–97.CrossRefGoogle ScholarPubMed
Klepstad, P, Loge, JH, Borchgrevink, PC, Mendoza, TR, Cleeland, CS and Kaasa, S (2002) The Norwegian brief pain inventory questionnaire: translation and validation in cancer pain patients. Journal of Pain and Symptom Management 24, 517–525.CrossRefGoogle ScholarPubMed
Koob, GF and Le Moal, M (2001) Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 24, 97–129.CrossRefGoogle ScholarPubMed
Koob, GF and Le Moal, M (2008) Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society B: Biological Sciences 363, 3113.CrossRefGoogle ScholarPubMed
Koob, GF and Moal, ML (1997) Drug abuse: hedonic homeostatic dysregulation. Science 278, 52–58.CrossRefGoogle ScholarPubMed
Kumar, P, Waiter, G, Ahearn, T, Milders, M, Reid, I and Steele, JD (2008) Abnormal temporal difference reward-learning signals in major depression. Brain 131, 2084–2093.CrossRefGoogle ScholarPubMed
Kumar, P, Goer, F, Murray, L, Dillon, DG, Beltzer, ML, Cohen, AL, Brooks, NH and Pizzagalli, DA (2018) Impaired reward prediction error encoding and striatal-midbrain connectivity in depression. Neuropsychopharmacology 43, 1581–1588.CrossRefGoogle ScholarPubMed
Lansdall, CJ, Coyle-Gilchrist, ITS, Jones, PS, Vázquez Rodríguez, P, Wilcox, A, Wehmann, E, Dick, KM, Robbins, TW and Rowe, JB (2017) Apathy and impulsivity in frontotemporal lobar degeneration syndromes. Brain 140, 1792–1807.CrossRefGoogle ScholarPubMed
Lawson, RP, Nord, CL, Seymour, B, Thomas, DL, Dayan, P, Pilling, S and Roiser, JP (2017) Disrupted habenula function in major depression. Molecular Psychiatry 22, 202–208.CrossRefGoogle ScholarPubMed
Lee, M, Manders, TR, Eberle, SE, Su, C, D'amour, J, Yang, R, Lin, HY, Deisseroth, K, Froemke, RC and Wang, J (2015) Activation of corticostriatal circuitry relieves chronic neuropathic pain. The Journal of Neuroscience 35, 5247–5259.CrossRefGoogle ScholarPubMed
Leknes, S and Tracey, I (2008) A common neurobiology for pain and pleasure. Nature Reviews Neuroscience 9, 314–320.CrossRefGoogle ScholarPubMed
Liu, W-H, Wang, L-Z, Zhao, S-H, Ning, Y-P and Chan, RCK (2012 a) Anhedonia and emotional word memory in patients with depression. Psychiatry Research 200, 361–367.CrossRefGoogle ScholarPubMed
Liu, W-H, Wang, L-Z, Zhu, Y-H, Li, M-H and Chan, RCK (2012 b) Clinical utility of the Snaith-Hamilton-Pleasure scale in the Chinese settings. BMC Psychiatry 12, 184.CrossRefGoogle ScholarPubMed
Liu, W-H, Wang, L-Z, Shang, H-R, Shen, Y, Li, Z, Cheung, EFC and Chan, RCK (2014) The influence of anhedonia on feedback negativity in major depressive disorder. Neuropsychologia 53, 213–220.CrossRefGoogle ScholarPubMed
Liu, W-H, Roiser, JP, Wang, L-Z, Zhu, Y-H, Huang, J, Neumann, DL, Shum, DH, Cheung, EF and Chan, RC (2016) Anhedonia is associated with blunted reward sensitivity in first-degree relatives of patients with major depression. Journal of Affective Disorders 190, 640–648.CrossRefGoogle ScholarPubMed
Loggia, ML, Berna, C, Kim, J, Cahalan, CM, Gollub, RL, Wasan, AD, Harris, RE, Edwards, RR and Napadow, V (2014) Disrupted brain circuitry for pain-related reward/punishment in fibromyalgia. Arthritis and Rheumatism 66, 203–212.CrossRefGoogle ScholarPubMed
Mann, CL, Footer, O, Chung, YS, Driscoll, LL and Barch, DM (2013) Spared and impaired aspects of motivated cognitive control in schizophrenia. Journal of Abnormal Psychology 122, 745–755.CrossRefGoogle Scholar
Marbach, JJ and Lund, P (1981) Depression, anhedonia and anxiety in temporomandibular joint and other facial pain syndromes. Pain 11, 73–84.CrossRefGoogle ScholarPubMed
Marbach, JJ, Richlin, DM and Lipton, JA (1983) Illness behavior, depression and anhedonia in myofascial face and back pain patients. Psychotherapy and Psychosomatics 39, 47–54.CrossRefGoogle ScholarPubMed
Martikainen, IK, Peciña, M, Love, TM, Nuechterlein, EB, Cummiford, CM, Green, CR, Harris, RE, Stohler, CS and Zubieta, J-K (2013) Alterations in endogenous opioid functional measures in chronic back pain. The Journal of Neuroscience 33, 14729–14737.CrossRefGoogle ScholarPubMed
McCabe, C, Woffindale, C, Harmer, CJ and Cowen, PJ (2012) Neural processing of reward and punishment in young people at increased familial risk of depression. Biological Psychiatry 72, 588–594.CrossRefGoogle ScholarPubMed
Meltzer, EC, Rybin, D, Saitz, R, Samet, JH, Schwartz, SL, Butler, SF and Liebschutz, JM (2011) Identifying prescription opioid use disorder in primary care: diagnostic characteristics of the Current Opioid Misuse Measure (COMM). Pain 152, 397–402.CrossRefGoogle Scholar
Meshesha, LZ, Pickover, AM, Teeters, JB and Murphy, JG (2017) A longitudinal behavioral economic analysis of non-medical prescription opioid use among college students. The Psychological Record 67, 241–251.CrossRefGoogle Scholar
Misaki, M, Suzuki, H, Savitz, J, Drevets, WC and Bodurka, J (2016) Individual variations in nucleus accumbens responses associated with major depressive disorder symptoms. Scientific reports 6, 21227.CrossRefGoogle ScholarPubMed
Nagashima, K, Noma, H and Furukawa, TA (2019) Prediction intervals for random-effects meta-analysis: A confidence distribution approach. Statistical Methods in Medical Research 28 1689–1702.CrossRefGoogle ScholarPubMed
Narayana, A, Katz, N, Shillington, AC, Stephenson, JJ, Harshaw, Q, Frye, CB and Portenoy, RK (2015) National breakthrough pain study: prevalence, characteristics, and associations with health outcomes. Pain 156, 252–259.CrossRefGoogle ScholarPubMed
Ng, CG, Chin, SC, Yee, AHA, Loh, HS, Sulaiman, AH, Sherianne Sook Kuan, W and Habil, MH (2014) Validation of Malay version of Snaith-Hamilton Pleasure Scale: comparison between depressed patients and healthy subjects at an out-patient clinic in Malaysia. The Malaysian Journal of Medical Sciences 21, 62–70.Google ScholarPubMed
Norbury, A, Kurth-Nelson, Z, Winston, JS, Roiser, JP and Husain, M (2015) Dopamine regulates approach-avoidance in human sensation-seeking. International Journal of Neuropsychopharmacology 18, pyv041.CrossRefGoogle ScholarPubMed
Nugent, AC, Ballard, ED, Gould, TD, Park, LT, Moaddel, R, Brutsche, NE and Zarate, CA (2018) Ketamine has distinct electrophysiological and behavioral effects in depressed and healthy subjects. Molecular Psychiatry 24, 1040–1052.CrossRefGoogle ScholarPubMed
Osuch, EA, Manning, K, Hegele, RA, Théberge, J, Neufeld, R, Mitchell, D, Williamson, P and Gardner, RC (2016) Depression, marijuana use and early-onset marijuana use conferred unique effects on neural connectivity and cognition. Acta Psychiatrica Scandinavica 134, 399–409.CrossRefGoogle ScholarPubMed
Pechtel, P and Pizzagalli, DA (2013) Disrupted reinforcement learning and maladaptive behavior in women with a history of childhood sexual abuse: a high-density event-related potential study. JAMA Psychiatry 70, 499–507.CrossRefGoogle ScholarPubMed
Pechtel, P, Dutra, SJ, Goetz, EL and Pizzagalli, DA (2013) Blunted reward responsiveness in remitted depression. Journal of Psychiatric Research 47, 1864–1869.CrossRefGoogle ScholarPubMed
Porcelli, AJ and Delgado, MR (2017) Stress and decision making: effects on valuation, learning, and risk-taking. Current Opinion in Behavioral Sciences 14, 33–39.CrossRefGoogle ScholarPubMed
Price, RC, Christou, NV, Backman, SB, Stone, L and Schweinhardt, P (2016) Opioid-receptor antagonism increases pain and decreases pleasure in obese and non-obese individuals. Psychopharmacology 233, 3869–3879.CrossRefGoogle ScholarPubMed
R Core Team (2018) R: A language and environment for statistical computing. R Foundation for Statistical Computing: Vienna, Austria.Google Scholar
Raudenbush, S and Bryk, A (2002) Hierarchical Linear Models: Applications and Data Analysis Methods. Thousand Oaks: Sage Publications.Google Scholar
Renfroe, JB, Bradley, MM, Okun, MS and Bowers, D (2016) Motivational engagement in Parkinson's disease: preparation for motivated action. International Journal of Psychophysiology 99, 24–32.CrossRefGoogle ScholarPubMed
Ricciardi, L, Ferrazzano, G, Demartini, B, Morgante, F, Erro, R, Ganos, C, Bhatia, KP, Berardelli, A and Edwards, M (2016) Know thyself: exploring interoceptive sensitivity in Parkinson's disease. Journal of the Neurological Sciences 364, 110–115.CrossRefGoogle ScholarPubMed
Rodriguez-Raecke, R, Niemeier, A, Ihle, K, Ruether, W and May, A (2009) Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. The Journal of Neuroscience 29, 13746–13750.CrossRefGoogle Scholar
Ryu, V (2013) Dysfunctional reward learning in bipolar disorder: An event-related potential study. PhD thesis. Yonsei University. Seoul. Available at: https://ir.ymlib.yonsei.ac.kr/handle/22282913/136444 (Accessed: 13 December 2018).Google Scholar
Rzepa, E and McCabe, C (2016) Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology. Journal of Psychiatric Research 82, 40–47.CrossRefGoogle ScholarPubMed
Scheidegger, M, Walter, M, Lehmann, M, Metzger, C, Grimm, S, Boeker, H, Boesiger, P, Henning, A and Seifritz, E (2012) Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action. PLOS ONE 7, e44799.CrossRefGoogle ScholarPubMed
Schwartz, N, Miller, C and Fields, HL.Cortico-accumbens regulation of approach-avoidance behavior is modified by experience and chronic pain. Cell Reports 19, 1522–1531.CrossRefGoogle Scholar
Schwartz, N, Temkin, P, Jurado, S, Lim, BK, Heifets, BD, Polepalli, JS and Malenka, RC (2014) Decreased motivation during chronic pain requires long-term depression in the nucleus accumbens. Science 345, 535–542.CrossRefGoogle ScholarPubMed
Seminowicz, DA, Wideman, TH, Naso, L, Hatami-Khoroushahi, Z, Fallatah, S, Ware, MA, Jarzem, P, Bushnell, MC, Shir, Y, Ouellet, JA and Stone, LS (2011) Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function. The Journal of Neuroscience 31, 7540–7550.CrossRefGoogle ScholarPubMed
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, Hergueta, T, Baker, R and Dunbar, GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry 59(suppl. 20), 22–33.Google ScholarPubMed
Shurman, J, Koob, GF and Gutstein, HB (2010) Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Medicine 11, 1092–1098.CrossRefGoogle ScholarPubMed
Snaith, R, Hamilton, M, Morley, S, Humayan, A, Hargreaves, D and Trigwell, P (1995) A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale. British Journal of Psychiatry 167, 99–103.CrossRefGoogle ScholarPubMed
Snijders, TAB and Bosker, RJ (1999) Multilevel Analysis: An Introduction to Basic and Advanced Multilevel Modeling. Thousand Oaks: Sage Publications.Google Scholar
Sprengelmeyer, R, Steele, JD, Mwangi, B, Kumar, P, Christmas, D, Milders, M and Matthews, K (2011) The insular cortex and the neuroanatomy of major depression. Journal of Affective Disorders 133, 120–127.CrossRefGoogle ScholarPubMed
Sprenger, T, Valet, M, Boecker, H, Henriksen, G, Spilker, M, Willoch, F, Wagner, K, Wester, H and Tolle, T (2006) Opioidergic activation in the medial pain system after heat pain. Pain 122, 63–67.CrossRefGoogle ScholarPubMed
Steele, JD, Kumar, P and Ebmeier, KP (2007) Blunted response to feedback information in depressive illness. Brain 130, 2367–2374.CrossRefGoogle ScholarPubMed
Stefaan Van, D, Geert, C and Jürgen, L (2007) Pain draws visual attention to its location: experimental evidence for a threat-related bias. The Journal of Pain 8, 976–982.Google Scholar
Stevens, A, Peschk, I and Schwarz, J (2007) Implicit learning, executive function and hedonic activity in chronic polydrug abusers, currently abstinent polydrug abusers and controls. Addiction 102, 937–946.CrossRefGoogle ScholarPubMed
Szczepanik, JE, Furey, ML, Nugent, AC, Henter, ID, Zarate, CA Jr and Lejuez, CW (2017) Altered interaction with environmental reinforcers in major depressive disorder: Relationship to anhedonia. Behaviour Research and Therapy 97, 170–177.CrossRefGoogle ScholarPubMed
Thompson, SJ, Pitcher, MH, Stone, LS, Tarum, F, Niu, G, Chen, X, Kiesewetter, DO, Schweinhardt, P and Bushnell, MC (2018) Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat. The Journal of Neuroscience 159, 1856–1866.Google ScholarPubMed
Tudge, L, Williams, C, Cowen, PJ and McCabe, C (2015) Neural effects of cannabinoid CB1 neutral antagonist tetrahydrocannabivarin on food reward and aversion in healthy volunteers. International Journal of Neuropsychopharmacology 18, pyu094.CrossRefGoogle Scholar
Ubl, B, Kuehner, C, Kirsch, P, Ruttorf, M, Diener, C and Flor, H (2015) Altered neural reward and loss processing and prediction error signalling in depression. Social Cognitive and Affective Neuroscience 10, 1102–1112.CrossRefGoogle ScholarPubMed
Veroniki, AA, Jackson, D, Viechtbauer, W, Bender, R, Bowden, J, Knapp, G, Kuss, O, Higgins, JP, Langan, D and Salanti, G (2016) Methods to estimate the between-study variance and its uncertainty in meta-analysis. Research Synthesis Methods 7, 55–79.CrossRefGoogle ScholarPubMed
Viechtbauer, W (2010) Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 36, 1–48.CrossRefGoogle Scholar
Volkow, ND and McLellan, AT (2016) Opioid abuse in chronic pain – misconceptions and mitigation strategies. New England Journal of Medicine 374, 1253–1263.CrossRefGoogle ScholarPubMed
Vowles, KE, McEntee, ML, Julnes, PS, Frohe, T, Ney, JP and van der Goes, DN (2015) Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain 156, 569–576.CrossRefGoogle ScholarPubMed
Vrieze, E, Ceccarini, J, Pizzagalli, DA, Bormans, G, Vandenbulcke, M, Demyttenaere, K, Van Laere, K and Claes, S (2013) Measuring extrastriatal dopamine release during a reward learning task. Human Brain Mapping 34, 575–586.Google ScholarPubMed
Walsh, AE, Browning, M, Drevets, WC, Furey, M and Harmer, CJ (2018) Dissociable temporal effects of bupropion on behavioural measures of emotional and reward processing in depression. Philosophical Transactions of the Royal Society B 373, 20170030.CrossRefGoogle ScholarPubMed
Yang, X-H, Wang, Y, Wang, D-F, Tian, K, Cheung, EFC, Xie, G-R and Chan, RC (2017) White matter microstructural abnormalities and their association with anticipatory anhedonia in depression. Psychiatry Research: Neuroimaging 264, 29–34.CrossRefGoogle ScholarPubMed
Yoshida, K, Shimizu, Y, Yoshimoto, J, Takamura, M, Okada, G, Okamoto, Y, Yamawaki, S and Doya, K (2017) Prediction of clinical depression scores and detection of changes in whole-brain using resting-state functional MRI data with partial least squares regression. PloS ONE 12, e0179638.CrossRefGoogle ScholarPubMed
Young, KD, Bellgowan, PSF, Bodurka, J and Drevets, WC (2013) Behavioral and neurophysiological correlates of autobiographical memory deficits in patients with depression and individuals at high risk for depression. JAMA Psychiatry 70, 698–708.CrossRefGoogle ScholarPubMed
Young, KD, Bellgowan, PSF, Bodurka, J and Drevets, WC (2014) Neurophysiological correlates of autobiographical memory deficits in currently and formerly depressed subjects. Psychological Medicine 44, 2951–2963.CrossRefGoogle ScholarPubMed
Zijlstra, F, Veltman, DJ, Booij, J, van den Brink, W and Franken, IH (2009) Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males. Drug and Alcohol Dependence 99, 183–192.CrossRefGoogle ScholarPubMed
Zubieta, J-K, Smith, YR, Bueller, JA, Xu, Y, Kilbourn, MR, Jewett, DM, Meyer, CR, Koeppe, RA and Stohler, CS (2001) Regional mu opioid receptor regulation of sensory and affective dimensions of pain. Science 293, 311–315.CrossRefGoogle ScholarPubMed
Supplementary material: File

Garland et al. supplementary material

Tables S1 and S2

Download Garland et al. supplementary material(File)
File 15.1 KB
Supplementary material: Image

Garland et al. supplementary material

Figure S1

Download Garland et al. supplementary material(Image)
Image 443.3 KB