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An overlapping pattern of cerebral cortical thinning is associated with both positive symptoms and aggression in schizophrenia via the ENIGMA consortium

Published online by Cambridge University Press:  16 October 2019

Ting Yat Wong Open the ORCID record for Ting Yat Wong [Opens in a new window] ,
Joaquim Radua ,
Edith Pomarol-Clotet ,
Raymond Salvador ,
Anton Albajes-Eizagirre ,
Aleix Solanes ,
Erick J. Canales-Rodriguez ,
Amalia Guerrero-Pedraza ,
Salvador Sarro  and
Tilo Kircher
...Show all authors
Ting Yat Wong*
Affiliation:
Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Aachen, RWTH Aachen University, Aachen, Germany Department of Psychiatry, Brain and Behavioral Laboratory, University of Pennsylvania, Philadelphia, PA, USA
Ruben C. Gur
Affiliation:
Department of Psychiatry, Brain and Behavioral Laboratory, University of Pennsylvania, Philadelphia, PA, USA
Thomas Nickl-Jockschat
Affiliation:
Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Aachen, RWTH Aachen University, Aachen, Germany Department of Psychiatry, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
*
Author for correspondence: Ting Yat Wong, E-mail: [email protected], [email protected]
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Abstract

Background

Positive symptoms are a useful predictor of aggression in schizophrenia. Although a similar pattern of abnormal brain structures related to both positive symptoms and aggression has been reported, this observation has not yet been confirmed in a single sample.

Method

To study the association between positive symptoms and aggression in schizophrenia on a neurobiological level, a prospective meta-analytic approach was employed to analyze harmonized structural neuroimaging data from 10 research centers worldwide. We analyzed brain MRI scans from 902 individuals with a primary diagnosis of schizophrenia and 952 healthy controls.

Results

The result identified a widespread cortical thickness reduction in schizophrenia compared to their controls. Two separate meta-regression analyses revealed that a common pattern of reduced cortical gray matter thickness within the left lateral temporal lobe and right midcingulate cortex was significantly associated with both positive symptoms and aggression.

Conclusion

These findings suggested that positive symptoms such as formal thought disorder and auditory misperception, combined with cognitive impairments reflecting difficulties in deploying an adaptive control toward perceived threats, could escalate the likelihood of aggression in schizophrenia.

Keywords

Aggressioncerebral cortical thinninghostilityimpulse controlpositive symptomsprospective meta-analysisschizophrenia
Type
Original Articles
Information
Psychological Medicine , Volume 50 , Issue 12 , September 2020 , pp. 2034 - 2045
Copyright
Copyright © Cambridge University Press 2019

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Footnotes

See the Appendix for additional affiliations of authors, grouped by each research site. For more details regarding the ENIGMA Schizophrenia Working Group (ENIGMA-SZ), see http://enigma.ini.usc.edu/ongoing/enigma-schizophrenia-working-group/.

*

Affiliation information for all authors can be found in the appendix at the end of the article.

References

Allen, JJ and Anderson, CA (2017) Aggression and Violence: Definitions and Distinctions. In Sturmey, P. (Ed.), The Wiley Handbook of Violence and Aggression. Chichester, West Sussex, UK: John Wiley & Sons, Ltd, pp. 1–14.Google Scholar
Allen, JJ, Anderson, CA and Bushman, BJ (2018) The general aggression model. Current Opinion in Psychology 19, 75–80.CrossRefGoogle ScholarPubMed
Allen, P, Modinos, G, Hubl, D, Shields, G, Cachia, A, Jardri, R, Thomas, P, Woodward, T, Shotbolt, P, Plaze, M and Hoffman, R (2012) Neuroimaging auditory hallucinations in schizophrenia: from neuroanatomy to neurochemistry and beyond. Schizophrenia Bulletin 38, 695–703.CrossRefGoogle ScholarPubMed
Anderson, CA and Bushman, BJ (2002) Human aggression. Annual Review of Psychology 53, 27–51.CrossRefGoogle ScholarPubMed
Arseneault, L, Moffitt, TE, Caspi, A, Taylor, PJ and Silva, PA (2000) Mental disorders and violence in a total birth cohort: results from the Dunedin study. Archives of General Psychiatry 57, 979–986.CrossRefGoogle Scholar
Benjamini, Y and Hochberg, Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society 57, 289–300.Google Scholar
Bersani, FS, Minichino, A, Fojanesi, M, Gallo, M, Maglio, G, Valeriani, G, Biondi, M and Fitzgerald, PB (2014) Cingulate cortex in schizophrenia: its relation with negative symptoms and psychotic onset. A review study. European Review for Medical and Pharmacological Sciences 18, 3354–3367.Google ScholarPubMed
Bjørkly, S (2002) Psychotic symptoms and violence toward others – A literature review of some preliminary findings: part 1. Delusions. Aggression and Violent Behavior 7, 617–631.CrossRefGoogle Scholar
Blair, RJR (2010) Psychopathy, frustration, and reactive aggression: the role of ventromedial prefrontal cortex. British Journal of Psychology 101, 383–399.CrossRefGoogle ScholarPubMed
Blair, RJR (2016) The neurobiology of impulsive aggression. Journal of Child and Adolescent Psychopharmacology 26, 4–9.CrossRefGoogle ScholarPubMed
Blake, P and Grafman, J (2004) The neurobiology of aggression. Lancet 364, 12–13.CrossRefGoogle ScholarPubMed
Brennan, PA, Mednick, SA and Hodgins, S (2000) Major mental disorders and criminal violence in a Danish birth cohort. Archives of General Psychiatry 57, 494.CrossRefGoogle Scholar
Buss, AH and Perry, M (1992) The aggression questionnaire. Journal of Personality 63, 452–459.Google ScholarPubMed
Catani, M, Dell'Acqua, F, Bizzi, A, Forkel, SJ, Williams, SC, Simmons, A, Murphy, DG and Thiebaut de Schotten, M (2012) Beyond cortical localization in clinico-anatomical correlation. Cortex 48, 1262–1287.CrossRefGoogle ScholarPubMed
Cheung, P, Schweitzer, I, Crowley, K and Tuckwell, V (1997) Aggressive behaviour in schizophrenia: role of state versus trait factors. Psychiatry Research 72, 41–50.CrossRefGoogle ScholarPubMed
Clement, S, Schauman, O, Graham, T, Maggioni, F, Evans-Lacko, S, Bezborodovs, N, Morgan, C, Rüsch, N, Brown, JSL and Thornicroft, G (2015) What is the impact of mental health-related stigma on help-seeking? A systematic review of quantitative and qualitative studies. Psychological Medicine 45, 11–27.CrossRefGoogle ScholarPubMed
Coccaro, EF, Sripada, CS, Yanowitch, RN and Phan, KL (2011) Corticolimbic function in impulsive aggressive behavior. Biological Psychiatry 69, 1153–1159.CrossRefGoogle ScholarPubMed
Coccaro, EF, Fitzgerald, DA, Lee, R, McCloskey, M and Phan, KL (2016) Frontolimbic morphometric abnormalities in intermittent explosive disorder and aggression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 1, 32–38.Google ScholarPubMed
Coid, JW, Ullrich, S, Kallis, C, Keers, R, Barker, D, Cowden, F and Stamps, R (2013) The relationship between delusions and violence: findings from the East London first episode psychosis study. JAMA Psychiatry 70, 465–471.CrossRefGoogle ScholarPubMed
Dack, C, Ross, J, Papadopoulos, C, Stewart, D and Bowers, L (2013) A review and meta-analysis of the patient factors associated with psychiatric in-patient aggression. Acta Psychiatrica Scandinavica 127, 255–268.CrossRefGoogle ScholarPubMed
Dambacher, F, Schuhmann, T, Lobbestael, J, Arntz, A, Brugman, S and Sack, AT (2015) Reducing proactive aggression through non-invasive brain stimulation. Social Cognitive and Affective Neuroscience 10, 1303–1309.10.1093/scan/nsv018CrossRefGoogle ScholarPubMed
Davidson, RJ, Putnam, KM and Larson, CL (2000) Dysfunction in the neural circuitry of emotion regulation – A possible prelude to violence. Science 289, 591–594.CrossRefGoogle ScholarPubMed
Del Re, AC (2013) compute.es: Compute Effect Sizes. R package. 0.2-2.Google Scholar
Desikan, RS, Ségonne, F, Fischl, B, Quinn, BT, Dickerson, BC, Blacker, D, Buckner, RL, Dale, AM, Maguire, RP, Hyman, BT, Albert, MS and Killiany, RJ (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage 31, 968–980.CrossRefGoogle ScholarPubMed
Devinsky, O, Morrell, MJ and Vogt, BA (1995) Contributions of anterior cingulate cortex to behaviour. Brain 118, 279–306.CrossRefGoogle ScholarPubMed
Douglas, KS, Guy, LS and Hart, SD (2009) Psychosis as a risk factor for violence to others: a meta-analysis. Psychological Bulletin 135, 679–706.CrossRefGoogle ScholarPubMed
Etkin, A, Egner, T and Kalisch, R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Sciences 15, 85–93.CrossRefGoogle ScholarPubMed
Fanning, JR, Berman, ME, Mohn, RS and McCloskey, MS (2011) Perceived threat mediates the relationship between psychosis proneness and aggressive behavior. Psychiatry Research 186, 210–218.CrossRefGoogle ScholarPubMed
Fazel, S, Gulati, G, Linsell, L, Geddes, JR and Grann, M (2009) Schizophrenia and violence: systematic review and meta-analysis. PLoS Medicine 6, e1000120.CrossRefGoogle ScholarPubMed
Fischl, B, Salat, DH, Busa, E, Albert, M, Dieterich, M, Haselgrove, C, Van Der Kouwe, A, Killiany, R, Kennedy, D, Klaveness, S, Montillo, A, Makris, N, Rosen, B and Dale, AM (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341–355.CrossRefGoogle ScholarPubMed
Fjellvang, M, Grøning, L and Haukvik, UK (2018) Imaging violence in schizophrenia: a systematic review and critical discussion of the MRI literature. Frontiers in Psychiatry 9, 333.CrossRefGoogle ScholarPubMed
Fornito, A, Yücel, M, Dean, B, Wood, SJ and Pantelis, C (2009) Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology. Schizophrenia Bulletin 35, 973–993.CrossRefGoogle ScholarPubMed
Gaser, C, Nenadic, I, Volz, HP, Büchel, C and Sauer, H (2004) Neuroanatomy of ‘hearing voices’: a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia. Cerebral Cortex 14, 91–96.CrossRefGoogle Scholar
Girard, LC, Pingault, JB, Falissard, B, Boivin, M, Dionne, G and Tremblay, RE (2014) Physical aggression and language ability from 17 to 72 months: cross-lagged effects in a population sample. PLoS ONE 9, e112185.CrossRefGoogle Scholar
Gleghorn, JM, Garnett, ES, Nahmias, C, Brown, GM, Kaplan, RD, Szechtman, H, Szechtman, B, Franco, S, Dermer, SW and Cook, P (1990) Regional brain metabolism during auditory hallucinations in chronic schizophrenia. British Journal of Psychiatry 157, 562–570.CrossRefGoogle Scholar
Goltz, HH (2010) Yule–Simpson's paradox in research. Practical Assessment, Research & Evaluation 15, 1–9.Google Scholar
Gur, RE, Cowell, P, Turetsky, BI, Gallacher, F, Cannon, T, Bilker, W and Gur, RC (1998) A follow-up magnetic resonance imaging study of schizophrenia: relationship of neuroanatomical changes to clinical and neurobehavioral measures. Archives of General Psychiatry 55, 145–152.CrossRefGoogle ScholarPubMed
He, Y, Chen, ZJ and Evans, AC (2007) Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Cerebral Cortex 17, 2407–2419.CrossRefGoogle ScholarPubMed
Hodgins, S, Alderton, J, Cree, A, Aboud, A and Mak, T (2007) Aggressive behaviour, victimisation and crime among severely mentally ill patients requiring hospitalisation. British Journal of Psychiatry 191, 343–350.CrossRefGoogle Scholar
Hoffstaedter, F, Grefkes, C, Zilles, K and Eickhoff, SB (2013) The ‘what’ and ‘when’ of self-initiated movements. Cerebral Cortex 23, 520–530.10.1093/cercor/bhr391CrossRefGoogle ScholarPubMed
Hoffstaedter, F, Grefkes, C, Caspers, S, Roski, C, Palomero-Gallagher, N, Laird, AR, Fox, PT and Eickhoff, SB (2014) The role of anterior midcingulate cortex in cognitive motor control: evidence from functional connectivity analyses. Human Brain Mapping 35, 2741–2753.CrossRefGoogle ScholarPubMed
Hoptman, MJ (2015) Impulsivity and aggression in schizophrenia: a neural circuitry perspective with implications for treatment. CNS Spectrums 20, 280–286.CrossRefGoogle ScholarPubMed
Hoptman, MJ, Volavka, J, Weiss, EM, Czobor, P, Szeszko, PR, Gerig, G, Chakos, M, Blocher, J, Citrome, LL, Lindenmayer, JP, Sheitman, B, Lieberman, JA and Bilder, RM (2005) Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. Psychiatry Research – Neuroimaging 140, 133–145.CrossRefGoogle ScholarPubMed
Horn, H, Federspiel, A, Wirth, M, Müller, TJ, Wiest, R, Wang, J-J and Strik, W (2009) Structural and metabolic changes in language areas linked to formal thought disorder. The British Journal of Psychiatry 194, 130–138.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A and Opler, LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261–276.CrossRefGoogle Scholar
Kuperberg, GR, Broome, MR, McGuire, PK, David, AS, Eddy, M, Ozawa, F, Goff, D, West, WC, Williams, SCR, van der Kouwe, AJW, Salat, DH, Dale, AM and Fischl, B (2003) Regionally localized thinning of the cerebral cortex in schizophrenia. Archives of General Psychiatry 60, 878–888.CrossRefGoogle Scholar
Kuroki, N, Shenton, ME, Salisbury, DF, Hirayasu, Y, Onitsuka, T, Ersner-Hershfield, H, Yurgelun-Todd, D, Kikinis, R, Jolesz, FA and McCarley, RW (2006) Middle and inferior temporal gyrus gray matter volume abnormalities in first-episode schizophrenia: an MRI study. American Journal of Psychiatry 163, 2103–2110.CrossRefGoogle Scholar
Large, MM and Nielssen, O (2011) Violence in first-episode psychosis: a systematic review and meta-analysis. Schizophrenia Research 125, 209–220.CrossRefGoogle ScholarPubMed
Lee, R, Arfanakis, K, Evia, AM, Fanning, J, Keedy, S and Coccaro, EF (2016) White matter integrity reductions in intermittent explosive disorder. Neuropsychopharmacology 41, 2697–2703.CrossRefGoogle ScholarPubMed
Levy, DA, Bayley, PJ and Squire, LR (2004) The anatomy of semantic knowledge: medial vs. lateral temporal lobe. Proceedings of the National Academy of Sciences 101, 6710–6715.CrossRefGoogle ScholarPubMed
Link, BG, Stueve, A and Phelan, J (1998) Psychotic symptoms and violent behaviors: probing the components of ‘threat/control-override’ symptoms. Social Psychiatry and Psychiatric Epidemiology 33, S55–S60.CrossRefGoogle ScholarPubMed
Manninen, M, Lindgren, M, Huttunen, M, Ebeling, H, Moilanen, I, Kalska, H, Suvisaari, J and Therman, S (2013) Low verbal ability predicts later violence in adolescent boys with serious conduct problems. Nordic Journal of Psychiatry 67, 289–297.CrossRefGoogle ScholarPubMed
Mesulam, M-M (1998) From sensation to cognition. Brain 121, 1013–1052.CrossRefGoogle Scholar
Modinos, G, Costafreda, SG, Van Tol, MJ, McGuire, PK, Aleman, A and Allen, P (2013) Neuroanatomy of auditory verbal hallucinations in schizophrenia: a quantitative meta-analysis of voxel-based morphometry studies. Cortex 49, 1046–1055.CrossRefGoogle ScholarPubMed
Narayan, VM, Narr, KL, Kumari, V, Woods, RP, Thompson, PM, Toga, AW and Sharma, T (2007) Regional cortical thinning in subjects with violent antisocial personality disorder or schizophrenia. American Journal of Psychiatry 164, 1418–1427.CrossRefGoogle ScholarPubMed
Narr, KL, Bilder, RM, Toga, AW, Woods, RP, Rex, DE, Szeszko, PR, Robinson, D, Sevy, S, Gunduz-Bruce, H, Wang, YP, DeLuca, H and Thompson, PM (2005) Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cerebral Cortex 15, 708–719.CrossRefGoogle ScholarPubMed
Nenadic, I, Yotter, RA, Sauer, H and Gaser, C (2015) Patterns of cortical thinning in different subgroups of schizophrenia. British Journal of Psychiatry 206, 479–483.CrossRefGoogle ScholarPubMed
Noga, JT, Aylward, E, Barta, PE and Pearlson, GD (1995) Cingulate gyrus in schizophrenic patients and normal volunteers. Psychiatry Research: Neuroimaging 61, 201–208.CrossRefGoogle ScholarPubMed
Nolan, KA, Czobor, P, Roy, BB, Platt, MM, Shope, CB, Citrome, LL and Volavka, J (2003) Characteristics of assaultive behaviour among psychiatric inpatients. Psychiatric Services 54, 1012–1016.CrossRefGoogle ScholarPubMed
Onitsuka, T, Shenton, ME, Salisbury, DF, Dickey, CC, Kasai, K, Toner, SK, Frumin, M, Kikinis, R, Jolesz, FA and McCarley, RW (2004) Middle and inferior temporal gyrus gray matter volume abnormalities in chronic schizophrenia: an MRI study. American Journal of Psychiatry 161, 1603–1611.CrossRefGoogle Scholar
R Core Team (2003) R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.Google Scholar
Ross, CA, Margolis, RL, Reading, SAJ, Pletnikov, M and Coyle, JT (2006) Neurobiology of schizophrenia. Neuron 52, 139–153.CrossRefGoogle ScholarPubMed
Sandyk, R (1993) Aggressive behavior in schizophrenia: relationship to age of onset and cortical atrophy. International Journal of Neuroscience 68, 1–10.CrossRefGoogle ScholarPubMed
Satterthwaite, TD, Wolf, DH, Calkins, ME, Vandekar, SN, Erus, G, Ruparel, K, Roalf, DR, Linn, KA, Elliott, MA, Moore, TM, Hakonarson, H, Shinohara, RT, Davatzikos, C, Gur, RC and Gur, RE (2016) Structural brain abnormalities in youth with psychosis spectrum symptoms. JAMA Psychiatry 73, 515.CrossRefGoogle ScholarPubMed
Schultz, CC, Koch, K, Wagner, G, Roebel, M, Nenadic, I, Schachtzabel, C, Reichenbach, JR, Sauer, H and Schlösser, RGM (2010) Complex pattern of cortical thinning in schizophrenia: results from an automated surface based analysis of cortical thickness. Psychiatry Research – Neuroimaging 182, 134–140.CrossRefGoogle ScholarPubMed
Shackman, AJ, Salomons, TV, Slagter, HA, Fox, AS, Winter, JJ and Davidson, RJ (2011) The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature Reviews Neuroscience 12, 154–167.CrossRefGoogle ScholarPubMed
Siever, LJ (2008) Neurobiology of aggression and violence. American Journal of Psychiatry 165, 429–442.CrossRefGoogle ScholarPubMed
Song, H and Min, SK (2009) Aggressive behavior model in schizophrenic patients. Psychiatry Research 167, 58–65.CrossRefGoogle ScholarPubMed
Soyka, M (2011) Neurobiology of aggression and violence in schizophrenia. Schizophrenia Bulletin 37, 913–920.CrossRefGoogle Scholar
Stuart, H (2003) Violence and mental illness: an overview. World Psychiatry 2, 121–124.Google ScholarPubMed
Swanson, JW, Swartz, MS, Van Dorn, RA, Elbogen, EB, Wagner, HR, Rosenheck, RA, Stroup, TS, McEvoy, JP and Lieberman, JA (2006) A national study of violent behavior in persons with schizophrenia. Archives of General Psychiatry 63, 490–499.CrossRefGoogle ScholarPubMed
Szechtman, H, Woody, E, Bowers, KS and Nahmias, C (1998) Where the imaginal appears real: a positron emission tomography study of auditory hallucinations. Proceedings of the National Academy of Sciences 95, 1956–1960.CrossRefGoogle ScholarPubMed
Thomas, WI and Thomas, DS (1928) The Child in America: Behavior Problems and Programs. New York: A. A. Knopf.Google Scholar
Thompson, PM, Stein, JL, Medland, SE, Hibar, DP, Vasquez, AA, Renteria, ME, Toro, R, Jahanshad, N, Schumann, G, Franke, B, Wright, MJ, Martin, NG, Agartz, I, Alda, M, Alhusaini, S, Almasy, L, Almeida, J, Alpert, K, Andreasen, NC, Andreassen, OA, Apostolova, LG, Appel, K, Armstrong, NJ, Aribisala, B, Bastin, ME, Bauer, M, Bearden, CE, Bergmann, Ø, Binder, EB, Blangero, J, Bockholt, HJ, Bøen, E, Bois, C, Boomsma, DI, Booth, T, Bowman, IJ, Bralten, J, Brouwer, RM, Brunner, HG, Brohawn, DG, Buckner, RL, Buitelaar, J, Bulayeva, K, Bustillo, JR, Calhoun, VD, Cannon, DM, Cantor, RM, Carless, MA, Caseras, X, Cavalleri, GL, Chakravarty, MM, Chang, KD, Ching, CRK, Christoforou, A, Cichon, S, Clark, VP, Conrod, P, Coppola, G, Crespo-Facorro, B, Curran, JE, Czisch, M, Deary, IJ, de Geus, EJC, den Braber, A, Delvecchio, G, Depondt, C, de Haan, L, de Zubicaray, GI, Dima, D, Dimitrova, R, Djurovic, S, Dong, H, Donohoe, G, Duggirala, R, Dyer, TD, Ehrlich, S, Ekman, CJ, Elvsåshagen, T, Emsell, L, Erk, S, Espeseth, T, Fagerness, J, Fears, S, Fedko, I, Fernández, G, Fisher, SE, Foroud, T, Fox, PT, Francks, C, Frangou, S, Frey, EM, Frodl, T, Frouin, V, Garavan, H, Giddaluru, S, Glahn, DC, Godlewska, B, Goldstein, RZ, Gollub, RL, Grabe, HJ, Grimm, O, Gruber, O, Guadalupe, T, Gur, RE, Gur, RC, Göring, HHH, Hagenaars, S, Hajek, T, Hall, GB, Hall, J, Hardy, J, Hartman, CA, Hass, J, Hatton, SN, Haukvik, UK, Hegenscheid, K, Heinz, A, Hickie, IB, Ho, BC, Hoehn, D, Hoekstra, PJ, Hollinshead, M, Holmes, AJ, Homuth, G, Hoogman, M, Hong, LE, Hosten, N, Hottenga, JJ, Hulshoff Pol, HE, Hwang, KS, Jack, CR, Jenkinson, M, Johnston, C, Jönsson, EG, Kahn, RS, Kasperaviciute, D, Kelly, S, Kim, S, Kochunov, P, Koenders, L, Krämer, B, Kwok, JBJ, Lagopoulos, J, Laje, G, Landen, M, Landman, BA, Lauriello, J, Lawrie, SM, Lee, PH, Le Hellard, S, Lemaître, H, Leonardo, CD, Li, C, Liberg, B, Liewald, DC, Liu, X, Lopez, LM, Loth, E, Lourdusamy, A, Luciano, M, Macciardi, F, Machielsen, MWJ, MacQueen, GM, Malt, UF, Mandl, R, Manoach, DS, Martinot, JL, Matarin, M, Mather, KA, Mattheisen, M, Mattingsdal, M, Meyer-Lindenberg, A, McDonald, C, McIntosh, AM, McMahon, FJ, McMahon, KL, Meisenzahl, E, Melle, I, Milaneschi, Y, Mohnke, S, Montgomery, GW, Morris, DW, Moses, EK, Mueller, BA, Muñoz Maniega, S, Mühleisen, TW, Müller-Myhsok, B, Mwangi, B, Nauck, M, Nho, K, Nichols, TE, Nilsson, L, Nugent, AC, Nyberg, L, Olvera, RL, Oosterlaan, J, Ophoff, RA, Pandolfo, M, Papalampropoulou-Tsiridou, M, Papmeyer, M, Paus, T, Pausova, Z, Pearlson, GD, Penninx, BW, Peterson, CP, Pfennig, A, Phillips, M, Pike, GB, Poline, JB, Potkin, SG, Pütz, B, Ramasamy, A, Rasmussen, J, Rietschel, M, Rijpkema, M, Risacher, SL, Roffman, JL, Roiz-Santiañez, R, Romanczuk-Seiferth, N, Rose, EJ, Royle, NA, Rujescu, D, Ryten, M, Sachdev, PS, Salami, A, Satterthwaite, TD, Savitz, J, Saykin, AJ, Scanlon, C, Schmaal, L, Schnack, HG, Schork, AJ, Schulz, SC, Schür, R, Seidman, L, Shen, L, Shoemaker, JM, Simmons, A, Sisodiya, SM, Smith, C, Smoller, JW, Soares, JC, Sponheim, SR, Sprooten, E, Starr, JM, Steen, VM, Strakowski, S, Strike, L, Sussmann, J, Sämann, PG, Teumer, A, Toga, AW, Tordesillas-Gutierrez, D, Trabzuni, D, Trost, S, Turner, J, Van den Heuvel, M, van der Wee, NJ, van Eijk, K, van Erp, TGM, van Haren, NEM, van ’t Ent, D, van Tol, MJ, Valdés Hernández, MC, Veltman, DJ, Versace, A, Völzke, H, Walker, R, Walter, H, Wang, L, Wardlaw, JM, Weale, ME, Weiner, MW, Wen, W, Westlye, LT, Whalley, HC, Whelan, CD, White, T, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Zilles, D, Zwiers, MP, Thalamuthu, A, Schofield, PR, Freimer, NB, Lawrence, NS, Drevets, W, Alzheimer's Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study (SYS) Group (2014) The ENIGMA consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior 8, 153–182.CrossRefGoogle ScholarPubMed
Tikàsz, A, Potvin, S, Lungu, O, Joyal, CC, Hodgins, S, Mendrek, A and Dumais, A (2016) Anterior cingulate hyperactivations during negative emotion processing among men with schizophrenia and a history of violent behavior. Neuropsychiatric Disease and Treatment 12, 1397–1410.Google Scholar
Torrey, EF (2011) Stigma and violence: isn't it time to connect the dots? Schizophrenia Bulletin 37, 892–896.CrossRefGoogle ScholarPubMed
Tsuang, MT, Lyons, MJ and Faraone, SV (1990) Heterogeneity of schizophrenia. Conceptual models and analytic strategies. British Journal of Psychiatry 156, 17–26.CrossRefGoogle ScholarPubMed
van der Gaag, M, Hoffman, T, Remijsen, M, Hijman, R, de Haan, L, van Meijel, B, van Harten, PN, Valmaggia, L, de Hert, M, Cuijpers, A and Wiersma, D (2006) The five-factor model of the positive and negative syndrome scale II: a ten-fold cross-validation of a revised model. Schizophrenia Research 85, 280–287.CrossRefGoogle ScholarPubMed
van Erp, TGM, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MWJ, Koenders, L, de Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, van Haren, NEM, Pol, HEH, Ophoff, RA, Kahn, RS, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jönsson, EG, Dimitrova, R, Bois, C, Whalley, HC, McIntosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM and Turner, JA (2016) Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry 21, 547–553.CrossRefGoogle ScholarPubMed
van Erp, TGM, Walton, E, Hibar, DP, Schmaal, L, Jiang, W, Glahn, DC, Pearlson, GD, Yao, N, Fukunaga, M, Hashimoto, R, Okada, N, Yamamori, H, Bustillo, JR, Clark, VP, Agartz, I, Mueller, BA, Cahn, W, de Zwarte, SMC, Hulshoff Pol, HE, Kahn, RS, Ophoff, RA, van Haren, NEM, Andreassen, OA, Dale, AM, Doan, NT, Gurholt, TP, Hartberg, CB, Haukvik, UK, Jørgensen, KN, Lagerberg, TV, Melle, I, Westlye, LT, Gruber, O, Kraemer, B, Richter, A, Zilles, D, Calhoun, VD, Crespo-Facorro, B, Roiz-Santiañez, R, Tordesillas-Gutiérrez, D, Loughland, C, Carr, VJ, Catts, S, Cropley, VL, Fullerton, JM, Green, MJ, Henskens, FA, Jablensky, A, Lenroot, RK, Mowry, BJ, Michie, PT, Pantelis, C, Quidé, Y, Schall, U, Scott, RJ, Cairns, MJ, Seal, M, Tooney, PA, Rasser, PE, Cooper, G, Shannon Weickert, C, Weickert, TW, Morris, DW, Hong, E, Kochunov, P, Beard, LM, Gur, RE, Gur, RC, Satterthwaite, TD, Wolf, DH, Belger, A, Brown, GG, Ford, JM, Macciardi, F, Mathalon, DH, O'Leary, DS, Potkin, SG, Preda, A, Voyvodic, J, Lim, KO, McEwen, S, Yang, F, Tan, Y, Tan, S, Wang, Z, Fan, F, Chen, J, Xiang, H, Tang, S, Guo, H, Wan, P, Wei, D, Bockholt, HJ, Ehrlich, S, Wolthusen, RPF, King, MD, Shoemaker, JM, Sponheim, SR, et al. (2018) Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) consortium. Biological Psychiatry 84, 644–654.CrossRefGoogle ScholarPubMed
Van Lutterveld, R, Van Den Heuvel, MP, Diederen, KMJ, De Weijer, AD, Begemann, MJH, Brouwer, RM, Daalman, K, Blom, JD, Kahn, RS and Sommer, IE (2014) Cortical thickness in individuals with non-clinical and clinical psychotic symptoms. Brain 137, 2664–2669.CrossRefGoogle ScholarPubMed
Vicens, V, Radua, J, Salvador, R, Anguera-Camós, M, Canales-Rodríguez, EJ, Sarró, S, Maristany, T, McKenna, PJ and Pomarol-Clotet, E (2016) Structural and functional brain changes in delusional disorder. British Journal of Psychiatry 208, 153–159.CrossRefGoogle ScholarPubMed
Viechtbauer, W (2010) Conducting meta-analyses in R with the metafor package. Journal of Statistical Software 36, 1–48.CrossRefGoogle Scholar
Vogt, BA (2016) Midcingulate cortex: structure, connections, homologies, functions and diseases. Journal of Chemical Neuroanatomy 74, 28–46.CrossRefGoogle ScholarPubMed
Volavka, J and Citrome, L (2008) Heterogeneity of violence in schizophrenia and implications for long-term treatment. International Journal of Clinical Practice 62, 1237–1245.CrossRefGoogle ScholarPubMed
Volavka, J and Citrome, L (2011) Pathways to aggression in schizophrenia affect results of treatment. Schizophrenia Bulletin 37, 921–929.CrossRefGoogle ScholarPubMed
Wallace, C, Mullen, PE and Burgess, P (2004) Criminal offending in schizophrenia over a 25-year period marked by deinstitutionalization and increasing prevalence of comorbid substance use disorders. American Journal of Psychiatry 161, 716–727.CrossRefGoogle Scholar
Wehring, HJ and Carpenter, WT (2011) Violence and schizophrenia. Schizophrenia Bulletin 37, 877–878.CrossRefGoogle Scholar
Weiss, EM (2012) Neuroimaging and neurocognitive correlates of aggression and violence in schizophrenia. Scientifica 2012, 1–12.CrossRefGoogle Scholar
Wensing, T, Cieslik, EC, Müller, VI, Hoffstaedter, F, Eickhoff, SB and Nickl-Jockschat, T (2017) Neural correlates of formal thought disorder: an activation likelihood estimation meta-analysis. Human Brain Mapping 38, 4946–4965.CrossRefGoogle ScholarPubMed
Wrangham, RW (2018) Two types of aggression in human evolution. Proceedings of the National Academy of Sciences 115, 245–253.CrossRefGoogle ScholarPubMed
Yang, Y, Joshi, SH, Jahanshad, N, Thompson, PM and Baker, LA (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggressive Behavior 43, 230–240.CrossRefGoogle ScholarPubMed
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