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Alcohol use is associated with thinner cerebral cortex and larger ventricles in schizophrenia, bipolar disorder and healthy controls

Published online by Cambridge University Press:  10 November 2016

E. H. Lange ,
S. Nerland ,
K. N. Jørgensen ,
L. Mørch-Johnsen ,
R. Nesvåg ,
C. B. Hartberg ,
U. K. Haukvik ,
K. Osnes ,
I. Melle  and
O. A. Andreassen
...Show all authors
E. H. Lange*
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
S. Nerland
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway
K. N. Jørgensen
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
L. Mørch-Johnsen
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
R. Nesvåg
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway Norwegian Institute of Public Health, Oslo, Norway
C. B. Hartberg
Affiliation:
NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
U. K. Haukvik
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
K. Osnes
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway
I. Melle
Affiliation:
NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Division of Mental Health and Addiciton, Oslo University Hospital, Oslo, Norway
O. A. Andreassen
Affiliation:
NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway Division of Mental Health and Addiciton, Oslo University Hospital, Oslo, Norway
I. Agartz
Affiliation:
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway NORMENT and K. G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
*
*Address for correspondence: E. H. Lange, MD, Department of Psychiatric Research, Diakonhjemmet Hospital, PO Box 85 Vinderen, 0319 Oslo, Norway. (Email: [email protected])
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Abstract

Background

Excessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association.

Method

1.5 T structural magnetic resonance images were acquired of 609 alcohol-using participants (165 schizophrenia patients, 172 bipolar disorder patients, 272 healthy controls), mean (s.d.) age 34.2 (9.9) years, 52% men. Past year alcohol use was assessed with the Alcohol Use Disorder Identification Test – Consumption part (AUDIT-C). General linear models were used to investigate associations between AUDIT-C score and cortical thickness, surface area, and total brain and subcortical volumes.

Results

Increasing AUDIT-C score was linearly associated with thinner cortex in medial and dorsolateral frontal and parieto-occipital regions, and with larger left lateral ventricle volume. There was no significant interaction between AUDIT-C score and diagnostic group. The findings remained significant after controlling for substance use disorders, antipsychotic medication and illness severity.

Conclusion

The results show a dose-dependent relationship between alcohol use and thinner cortex and ventricular expansion. The findings are present also at lower levels of alcohol consumption and do not differ between schizophrenia or bipolar disorder patients compared to healthy controls. Our results do not support previous findings of increased vulnerability for alcohol-related brain damage in severe mental illness.

Keywords

Alcohol consumptionalcohol-related disordersbraingray mattermagnetic resonance imagingpsychotic disorders
Type
Original Articles
Information
Psychological Medicine , Volume 47 , Issue 4 , March 2017 , pp. 655 - 668
Copyright
Copyright © Cambridge University Press 2016 

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References

Agartz, I, Brag, S, Franck, J, Hammarberg, A, Okugawa, G, Svinhufvud, K, Bergman, H (2003). MR volumetry during acute alcohol withdrawal and abstinence: a descriptive study. Alcohol and Alcoholism 38, 71–78.CrossRefGoogle ScholarPubMed
Agartz, I, Momenan, R, Rawlings, RR, Kerich, MJ, Hommer, DW (1999). Hippocampal volume in patients with alcohol dependence. Archives of General Psychiatry 56, 356–363.CrossRefGoogle ScholarPubMed
Andreasen, NC, Liu, D, Ziebell, S, Vora, A, Ho, BC (2013). Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. American Journal of Psychiatry 170, 609–615.CrossRefGoogle ScholarPubMed
Arnone, D, Cavanagh, J, Gerber, D, Lawrie, SM, Ebmeier, KP, McIntosh, AM (2009). Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. British Journal of Psychiatry 195, 194–201.CrossRefGoogle ScholarPubMed
Berman, AH, Bergman, H, Palmstierna, T, Schlyter, F (2005). Evaluation of the drug use disorders identification test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample. European Addiction Research 11, 22–31.CrossRefGoogle Scholar
Berman, S, O'Neill, J, Fears, S, Bartzokis, G, London, ED (2008). Abuse of amphetamines and structural abnormalities in the brain. Annals of the New York Academy of Sciences 1141, 195–220.CrossRefGoogle ScholarPubMed
Bora, E, Fornito, A, Yucel, M, Pantelis, C (2010). Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biological Psychiatry 67, 1097–1105.CrossRefGoogle ScholarPubMed
Bowirrat, A, Oscar-Berman, M (2005). Relationship between dopaminergic neurotransmission, alcoholism, and Reward Deficiency syndrome. American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics 132b, 29–37.CrossRefGoogle ScholarPubMed
Bradley, KA, DeBenedetti, AF, Volk, RJ, Williams, EC, Frank, D, Kivlahan, DR (2007). AUDIT-C as a brief screen for alcohol misuse in primary care. Alcoholism, Clinical and Experimental Research 31, 1208–1217.CrossRefGoogle ScholarPubMed
Buhler, M, Mann, K (2011). Alcohol and the human brain: a systematic review of different neuroimaging methods. Alcoholism, Clinical and Experimental Research 35, 1771–1793.CrossRefGoogle Scholar
Bush, K, Kivlahan, DR, McDonell, MB, Fihn, SD, Bradley, KA (1998). The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory Care Quality Improvement Project (ACQUIP). Alcohol Use Disorders Identification Test. Archives of Internal Medicine 158, 1789–1795.CrossRefGoogle ScholarPubMed
Cardenas, VA, Studholme, C, Gazdzinski, S, Durazzo, TC, Meyerhoff, DJ (2007). Deformation-based morphometry of brain changes in alcohol dependence and abstinence. Neuroimage 34, 879–887.CrossRefGoogle ScholarPubMed
Cardenas, VA, Studholme, C, Meyerhoff, DJ, Song, E, Weiner, MW (2005). Chronic active heavy drinking and family history of problem drinking modulate regional brain tissue volumes. Psychiatry Research 138, 115–130.CrossRefGoogle ScholarPubMed
Dale, AM, Fischl, B, Sereno, MI (1999). Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 9, 179–194.CrossRefGoogle ScholarPubMed
Davis, BJ, Vidal, JS, Garcia, M, Aspelund, T, van Buchem, MA, Jonsdottir, MK, Sigurdsson, S, Harris, TB, Gudnason, V, Launer, LJ (2014). The alcohol paradox: light-to-moderate alcohol consumption, cognitive function, and brain volume. Journals of Gerontology. Series A: Biological Sciences and Medical Sciences 69, 1528–1535.CrossRefGoogle ScholarPubMed
de Bruin, EA, Hulshoff Pol, HE, Bijl, S, Schnack, HG, Fluitman, S, Böcker, KBE, Kenemans, JL, Kahn, RS, Verbaten, MN (2005 a). Associations between alcohol intake and brain volumes in male and female moderate drinkers. Alcoholism: Clinical and Experimental Research 29, 656–663.CrossRefGoogle ScholarPubMed
de Bruin, EA, Hulshoff Pol, HE, Schnack, HG, Janssen, J, Bijl, S, Evans, AC, Kenemans, JL, Kahn, RS, Verbaten, MN (2005 b). Focal brain matter differences associated with lifetime alcohol intake and visual attention in male but not in female non-alcohol-dependent drinkers. Neuroimage 26, 536–545.CrossRefGoogle Scholar
den Heijer, T, Vermeer, SE, van Dijk, EJ, Prins, ND, Koudstaal, PJ, van Duijn, CM, Hofman, A, Breteler, MM (2004). Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia. American Journal of Clinical Nutrition 80, 992–997.CrossRefGoogle ScholarPubMed
Di Florio, A, Craddock, N, van den Bree, M (2014). Alcohol misuse in bipolar disorder. A systematic review and meta-analysis of comorbidity rates. European Psychiatry 29, 117–124.CrossRefGoogle ScholarPubMed
Ding, J, Eigenbrodt, ML, Mosley, TH Jr, Hutchinson, RG, Folsom, AR, Harris, TB, Nieto, FJ (2004). Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) study. Stroke 35, 16–21.CrossRefGoogle Scholar
Downer, B, Jiang, Y, Zanjani, F, Fardo, D (2015). Effects of alcohol consumption on cognition and regional brain volumes among older adults. American Journal of Alzheimers Disease and Other Dementias 30, 364–374.CrossRefGoogle ScholarPubMed
Doyle, SR, Donovan, DM, Kivlahan, DR (2007). The factor structure of the alcohol use disorders 14 identification test (AUDIT). Journal of Studies on Alcohol and Drugs 68, 474–479.CrossRefGoogle Scholar
Durazzo, TC, Tosun, D, Buckley, S, Gazdzinski, S, Mon, A, Fryer, SL, Meyerhoff, DJ (2011). Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. Alcoholism, Clinical and Experimental Research 35, 1187–1200.CrossRefGoogle ScholarPubMed
Ellison-Wright, I, Bullmore, E (2010). Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophrenia Research 117, 1–12.CrossRefGoogle ScholarPubMed
Fein, G, Di Sclafani, V, Cardenas, VA, Goldmann, H, Tolou-Shams, M, Meyerhoff, DJ (2002). Cortical gray matter loss in treatment-naive alcohol dependent individuals. Alcoholism, Clinical and Experimental Research 26, 558–564.Google ScholarPubMed
Fein, G, Shimotsu, R, Chu, R, Barakos, J (2009). Parietal gray matter volume loss is related to spatial processing deficits in long-term abstinent alcoholic men. Alcoholism, Clinical and Experimental Research 33, 1806–1814.CrossRefGoogle ScholarPubMed
First, MB, Spitzer, RL, Gibbon, M, Williams, JB (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version – Patient Edition (SCID-I/P, Version 2.0). Biometrics Research, New York State Psychiatric Institute: New York, US.Google Scholar
Fischl, B, Salat, DH, Busa, E, Albert, M, Dieterich, M, Haselgrove, C, van der, KA, Killiany, R, Kennedy, D, Klaveness, S, Montillo, A, Makris, N, Rosen, B, Dale, AM (2002). Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341–355.CrossRefGoogle ScholarPubMed
Fischl, B, Sereno, MI, Dale, AM (1999). Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system. Neuroimage 9, 195–207.CrossRefGoogle Scholar
Fortier, CB, Leritz, EC, Salat, DH, Venne, JR, Maksimovskiy, AL, Williams, V, Milberg, WP, McGlinchey, RE (2011). Reduced cortical thickness in abstinent alcoholics and association with alcoholic behavior. Alcoholism, Clinical and Experimental Research 35, 2193–2201.CrossRefGoogle ScholarPubMed
Gazdzinski, S, Durazzo, TC, Meyerhoff, DJ (2005). Temporal dynamics and determinants of whole brain tissue volume changes during recovery from alcohol dependence. Drug and Alcohol Dependence 78, 263–273.CrossRefGoogle ScholarPubMed
Genovese, CR, Lazar, NA, Nichols, T (2002). Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15, 870–878.CrossRefGoogle ScholarPubMed
Goldman, AL, Pezawas, L, Mattay, VS, Fischl, B, Verchinski, BA, Chen, Q, Weinberger, DR, Meyer-Lindenberg, A (2009). Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Archives of General Psychiatry 66, 467–477.CrossRefGoogle ScholarPubMed
Goldstein, BI, Velyvis, VP, Parikh, SV (2006). The association between moderate alcohol use and illness severity in bipolar disorder: a preliminary report. Journal of Clinical Psychiatry 67, 102–106.CrossRefGoogle ScholarPubMed
Grant, BF, Goldstein, RB, Saha, TD, Chou, SP, Jung, J, Zhang, H, Pickering, RP, Ruan, WJ, Smith, SM, Huang, B, Hasin, DS (2015). Epidemiology of DSM-5 alcohol use disorder: results from the national epidemiologic survey on alcohol and related conditions III. JAMA Psychiatry 72, 757–766.CrossRefGoogle ScholarPubMed
Gu, Y, Scarmeas, N, Short, EE, Luchsinger, JA, DeCarli, C, Stern, Y, Manly, JJ, Schupf, N, Mayeux, R, Brickman, AM (2014). Alcohol intake and brain structure in a multiethnic elderly cohort. Clinical Nutrition 33, 662–667.CrossRefGoogle Scholar
Gual, A, Segura, L, Contel, M, Heather, N, Colom, J (2002). Audit-3 and audit-4: effectiveness of two short forms of the alcohol use disorders identification test. Alcohol and Alcoholism 37, 591–596.CrossRefGoogle ScholarPubMed
Habets, P, Marcelis, M, Gronenschild, E, Drukker, M, van Os, J (2011). Reduced cortical thickness as an outcome of differential sensitivity to environmental risks in schizophrenia. Biological Psychiatry 69, 487–494.CrossRefGoogle ScholarPubMed
Haijma, SV, Van Haren, N, Cahn, W, Koolschijn, PC, Hulshoff Pol, HE, Kahn, RS (2013). Brain volumes in schizophrenia: a meta-analysis in over 18 000 subjects. Schizophrenia Bulletin 39, 1129–1138.CrossRefGoogle ScholarPubMed
Harper, C (2009). The neuropathology of alcohol-related brain damage. Alcohol and Alcoholism 44, 136–140.CrossRefGoogle ScholarPubMed
Hayakawa, K, Kumagai, H, Suzuki, Y, Furusawa, N, Haga, T, Hoshi, T, Fujiwara, Y, Yamaguchi, K (1992). MR imaging of chronic alcoholism. Acta Radiologica 33, 201–206.CrossRefGoogle ScholarPubMed
Hibar, DP, Westlye, LT, van Erp, TG, Rasmussen, J, Leonardo, CD, Faskowitz, J, Haukvik, UK, Hartberg, CB, Doan, NT, Agartz, I, Dale, AM, Gruber, O, Kramer, B, Trost, S, Liberg, B, Abe, C, Ekman, CJ, Ingvar, M, Landen, M, Fears, SC, Freimer, NB, Bearden, CE, Costa Rica/Colombia Consortium for Genetic Investigation of Bipolar E, Sprooten, E, Glahn, DC, Pearlson, GD, Emsell, L, Kenney, J, Scanlon, C, McDonald, C, Cannon, DM, Almeida, J, Versace, A, Caseras, X, Lawrence, NS, Phillips, ML, Dima, D, Delvecchio, G, Frangou, S, Satterthwaite, TD, Wolf, D, Houenou, J, Henry, C, Malt, UF, Boen, E, Elvsashagen, T, Young, AH, Lloyd, AJ, Goodwin, GM, Mackay, CE, Bourne, C, Bilderbeck, A, Abramovic, L, Boks, MP, van Haren, NE, Ophoff, RA, Kahn, RS, Bauer, M, Pfennig, A, Alda, M, Hajek, T, Mwangi, B, Soares, JC, Nickson, T, Dimitrova, R, Sussmann, JE, Hagenaars, S, Whalley, HC, McIntosh, AM, Thompson, PM, Andreassen, OA (2016). Subcortical volumetric abnormalities in bipolar disorder. Molecular Psychiatry. Published online: 9 February 2016. doi:10.1038/mp.2015.227.CrossRefGoogle ScholarPubMed
Ho, BC, Andreasen, NC, Ziebell, S, Pierson, R, Magnotta, V (2011). Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Archives of General Psychiatry 68, 128–137.CrossRefGoogle ScholarPubMed
Holm, S (1979). A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 6, 65–70.Google Scholar
Hommer, D, Momenan, R, Kaiser, E, Rawlings, R (2001). Evidence for a gender-related effect of alcoholism on brain volumes. American Journal of Psychiatry 158, 198–204.CrossRefGoogle ScholarPubMed
Hunt, GE, Malhi, GS, Cleary, M, Lai, HM, Sitharthan, T (2016). Prevalence of comorbid bipolar and substance use disorders in clinical settings, 1990–2015: systematic review and meta-analysis. Journal of Affective Disorders. Published online: 9 July 2016. doi:10.1016/j.jad.2016.07.011.Google ScholarPubMed
Ide, JS, Zhang, S, Hu, S, Sinha, R, Mazure, CM, Li, CS (2014). Cerebral gray matter volumes and low-frequency fluctuation of BOLD signals in cocaine dependence: duration of use and gender difference. Drug and Alcohol Dependence 134, 51–62.CrossRefGoogle ScholarPubMed
Isoda, M, Hikosaka, O (2007). Switching from automatic to controlled action by monkey medial frontal cortex. Nature Neuroscience 10, 240–248.CrossRefGoogle ScholarPubMed
Jernigan, TL, Butters, N, DiTraglia, G, Schafer, K, Smith, T, Irwin, M, Grant, I, Schuckit, M, Cermak, LS (1991). Reduced cerebral grey matter observed in alcoholics using magnetic resonance imaging. Alcoholism, Clinical and Experimental Research 15, 418–427.CrossRefGoogle ScholarPubMed
Jørgensen, KN, Skjaervo, I, Morch-Johnsen, L, Haukvik, UK, Lange, EH, Melle, I, Andreassen, OA, Agartz, I (2015). Cigarette smoking is associated with thinner cingulate and insular cortices in patients with severe mental illness. Journal of Psychiatry and Neuroscience 40, 241–249.CrossRefGoogle ScholarPubMed
Kaarne, T, Aalto, M, Kuokkanen, M, Seppa, K (2010). AUDIT-C, AUDIT-3 and AUDIT-QF in screening risky drinking among Finnish occupational health-care patients. Drug and Alcohol Review 29, 563–567.CrossRefGoogle ScholarPubMed
Kapogiannis, D, Kisser, J, Davatzikos, C, Ferrucci, L, Metter, J, Resnick, SM (2012). Alcohol consumption and premotor corpus callosum in older adults. European Neuropsychopharmacology 22, 704–710.CrossRefGoogle ScholarPubMed
Kay, SR, Fiszbein, A, Opler, LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261–276.CrossRefGoogle ScholarPubMed
Koob, GF (1999). The role of the striatopallidal and extended amygdala systems in drug addiction. Annals of the New York Academy of Sciences 877, 445–460.CrossRefGoogle ScholarPubMed
Koskinen, J, Lohonen, J, Koponen, H, Isohanni, M, Miettunen, J (2009). Prevalence of alcohol use disorders in schizophrenia–a systematic review and meta-analysis. Acta Psychiatrica Scandinavica 120, 85–96.CrossRefGoogle ScholarPubMed
Kril, JJ, Halliday, GM, Svoboda, MD, Cartwright, H (1997). The cerebral cortex is damaged in chronic alcoholics. Neuroscience 79, 983–998.CrossRefGoogle ScholarPubMed
Kubota, M, Nakazaki, S, Hirai, S, Saeki, N, Yamaura, A, Kusaka, T (2001). Alcohol consumption and frontal lobe shrinkage: study of 1432 non-alcoholic subjects. Journal of Neurology, Neurosurgery and Psychiatry 71, 104–106.CrossRefGoogle ScholarPubMed
Large, M, Mullin, K, Gupta, P, Harris, A, Nielssen, O (2014). Systematic meta-analysis of outcomes associated with psychosis and co-morbid substance use. Australian and New Zealand Journal of Psychiatry 48, 418–432.CrossRefGoogle ScholarPubMed
Lawyer, G, Bjerkan, PS, Hammarberg, A, Jayaram-Lindstrom, N, Franck, J, Agartz, I (2010). Amphetamine dependence and co-morbid alcohol abuse: associations to brain cortical thickness. BMC Pharmacology 10, 5.CrossRefGoogle ScholarPubMed
Levin, FR, Hennessy, G (2004). Bipolar disorder and substance abuse. Biological Psychiatry 56, 738–748.CrossRefGoogle ScholarPubMed
Lorenzetti, V, Lubman, DI, Whittle, S, Solowij, N, Yucel, M (2010). Structural MRI findings in long-term cannabis users: what do we know? Substance Use and Misuse 45, 1787–1808.CrossRefGoogle ScholarPubMed
Makris, N, Gasic, GP, Kennedy, DN, Hodge, SM, Kaiser, JR, Lee, MJ, Kim, BW, Blood, AJ, Evins, AE, Seidman, LJ, Iosifescu, DV, Lee, S, Baxter, C, Perlis, RH, Smoller, JW, Fava, M, Breiter, HC (2008 a). Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse? Neuron 60, 174–188.CrossRefGoogle Scholar
Makris, N, Oscar-Berman, M, Jaffin, SK, Hodge, SM, Kennedy, DN, Caviness, VS, Marinkovic, K, Breiter, HC, Gasic, GP, Harris, GJ (2008 b). Decreased volume of the brain reward system in alcoholism. Biological Psychiatry 64, 192–202.CrossRefGoogle ScholarPubMed
Mathalon, DH, Pfefferbaum, A, Lim, KO, Rosenbloom, MJ, Sullivan, EV (2003). Compounded brain volume deficits in schizophrenia-alcoholism comorbidity. Archives of General Psychiatry 60, 245–252.CrossRefGoogle ScholarPubMed
Mathiesen, EF, Nome, S, Richter, J, Eisemann, M (2012). Alcohol use patterns in a Norwegian general population-based sample with special reference to socio-demographic variables. Journal of Public Health 21, 241–249.CrossRefGoogle Scholar
Momenan, R, Steckler, LE, Saad, ZS, van Rafelghem, S, Kerich, MJ, Hommer, DW (2012). Effects of alcohol dependence on cortical thickness as determined by magnetic resonance imaging. Psychiatry Research 204, 101–111.CrossRefGoogle ScholarPubMed
Monnig, MA, Tonigan, JS, Yeo, RA, Thoma, RJ, McCrady, BS (2013). White matter volume in alcohol use disorders: a meta-analysis. Addiction Biology 18, 581–592.CrossRefGoogle ScholarPubMed
Mueser, KT, Drake, RE, Wallach, MA (1998). Dual diagnosis: a review of etiological theories. Addictive Behaviors 23, 717–734.CrossRefGoogle ScholarPubMed
Mukamal, KJ, Longstreth, WT Jr, Mittleman, MA, Crum, RM, Siscovick, DS (2001). Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health study. Stroke 32, 1939–1946.CrossRefGoogle ScholarPubMed
Nery, FG, Matsuo, K, Nicoletti, MA, Monkul, ES, Zunta-Soares, GB, Hatch, JP, Lafer, B, Soares, JC (2011). Association between prior alcohol use disorders and decreased prefrontal gray matter volumes in bipolar I disorder patients. Neuroscience Letters 503, 136–140.CrossRefGoogle ScholarPubMed
Nesvåg, R, Frigessi, A, Jonsson, EG, Agartz, I (2007). Effects of alcohol consumption and antipsychotic medication on brain morphology in schizophrenia. Schizophrenia Research 90, 52–61.CrossRefGoogle ScholarPubMed
Nesvåg, R, Knudsen, GP, Bakken, IJ, Hoye, A, Ystrom, E, Suren, P, Reneflot, A, Stoltenberg, C, Reichborn-Kjennerud, T (2015). Substance use disorders in schizophrenia, bipolar disorder, and depressive illness: a registry-based study. Social Psychiatry and Psychiatric Epidemiology 50, 1267–1276.CrossRefGoogle ScholarPubMed
Paul, CA, Au, R, Fredman, L, Massaro, JM, Seshadri, S, Decarli, C, Wolf, PA (2008). Association of alcohol consumption with brain volume in the Framingham study. Archives of Neurology 65, 1363–1367.CrossRefGoogle ScholarPubMed
Pedersen, G, Hagtvet, KA, Karterud, S (2007). Generalizability studies of the global assessment of functioning-split version. Comprehensive Psychiatry 48, 88–94.CrossRefGoogle ScholarPubMed
Pfefferbaum, A, Lim, KO, Zipursky, RB, Mathalon, DH, Rosenbloom, MJ, Lane, B, Ha, CN, Sullivan, EV (1992). Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcoholism, Clinical and Experimental Research 16, 1078–1089.CrossRefGoogle ScholarPubMed
Pfefferbaum, A, Rosenbloom, M, Deshmukh, A, Sullivan, E (2001). Sex differences in the effects of alcohol on brain structure. American Journal of Psychiatry 158, 188–197.CrossRefGoogle ScholarPubMed
Pfefferbaum, A, Rosenbloom, MJ, Chu, W, Sassoon, SA, Rohlfing, T, Pohl, KM, Zahr, NM, Sullivan, EV (2014). White matter microstructural recovery with abstinence and decline with relapse in alcohol dependence interacts with normal ageing: a controlled longitudinal DTI study. Lancet Psychiatry 1, 202–212.CrossRefGoogle ScholarPubMed
Pfefferbaum, A, Sullivan, EV, Mathalon, DH, Lim, KO (1997). Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcoholism, Clinical and Experimental Research 21, 521–529.CrossRefGoogle ScholarPubMed
Pfefferbaum, A, Sullivan, EV, Mathalon, DH, Shear, PK, Rosenbloom, MJ, Lim, KO (1995). Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcoholism, Clinical and Experimental Research 19, 1177–1191.CrossRefGoogle ScholarPubMed
Preti, A, Muscio, C, Boccardi, M, Lorenzi, M, de Girolamo, G, Frisoni, G (2014). Impact of alcohol consumption in healthy adults: a magnetic resonance imaging investigation. Psychiatry Research 224, 96–103.CrossRefGoogle ScholarPubMed
Rakic, P (1988). Specification of cerebral cortical areas. Science 241, 170–176.CrossRefGoogle ScholarPubMed
Rando, K, Hong, KI, Bhagwagar, Z, Li, CS, Bergquist, K, Guarnaccia, J, Sinha, R (2011). Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study. American Journal of Psychiatry 168, 183–192.CrossRefGoogle ScholarPubMed
Regier, DA, Farmer, ME, Rae, DS, Locke, BZ, Keith, SJ, Judd, LL, Goodwin, FK (1990). Comorbidity of mental disorders with alcohol and other drug abuse. Results from the epidemiologic catchment area (ECA) study. JAMA 264, 2511–2518.CrossRefGoogle ScholarPubMed
Reinert, DF, Allen, JP (2007). The alcohol use disorders identification test: an update of research findings. Alcoholism: Clinical and Experimental Research 31, 185–199.CrossRefGoogle ScholarPubMed
Ringen, PA, Lagerberg, TV, Birkenaes, AB, Engn, J, Faerden, A, Jonsdottir, H, Nesvåg, R, Friis, S, Opjordsmoen, S, Larsen, F, Melle, I, Andreassen, OA (2008). Differences in prevalence and patterns of substance use in schizophrenia and bipolar disorder. Psychological Medicine 38, 1241–1249.CrossRefGoogle ScholarPubMed
Rumpf, HJ, Hapke, U, Meyer, C, John, U (2002). Screening for alcohol use disorders and at-risk drinking in the general population: psychometric performance of three questionnaires. Alcohol and Alcoholism 37, 261–268.CrossRefGoogle ScholarPubMed
Rush, AJ, Gullion, CM, Basco, MR, Jarrett, RB, Trivedi, MH (1996). The Inventory of Depressive Symptomatology (IDS): psychometric properties. Psychological Medicine 26, 477–486.CrossRefGoogle ScholarPubMed
Sachdev, PS, Chen, X, Wen, W, Anstey, KJ (2008). Light to moderate alcohol use is associated with increased cortical gray matter in middle-aged men: a voxel-based morphometric study. Psychiatry Research 163, 61–69.CrossRefGoogle Scholar
Sasaki, H, Abe, O, Yamasue, H, Fukuda, R, Yamada, H, Takei, K, Suga, M, Takao, H, Kasai, K, Aoki, S, Ohtomo, K (2009). Structural and diffusional brain abnormality related to relatively low level alcohol consumption. Neuroimage 46, 505–510.CrossRefGoogle ScholarPubMed
Saunders, JB, Aasland, OG, Babor, TF, de, lF Jr, Grant, M (1993). Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption–II. Addiction 88, 791–804.CrossRefGoogle ScholarPubMed
Schiffer, B, Muller, BW, Scherbaum, N, Forsting, M, Wiltfang, J, Leygraf, N, Gizewski, ER (2010). Impulsivity-related brain volume deficits in schizophrenia-addiction comorbidity. Brain 133, 3093–3103.CrossRefGoogle ScholarPubMed
Smith, MJ, Wang, L, Cronenwett, W, Goldman, MB, Mamah, D, Barch, DM, Csernansky, JG (2011). Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia. Schizophrenia Research 131, 174–183.CrossRefGoogle ScholarPubMed
Spitzer, RL, Williams, JB, Kroenke, K, Linzer, M, deGruy, FV III, Hahn, SR, Brody, D, Johnson, JG (1994). Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study. Journal of the American Medical Association 272, 1749–1756.CrossRefGoogle ScholarPubMed
Sullivan, EV, Deshmukh, A, Desmond, JE, Lim, KO, Pfefferbaum, A (2000 a). Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: relation to ataxia. Neuropsychology 14, 341–352.CrossRefGoogle ScholarPubMed
Sullivan, EV, Deshmukh, A, Desmond, JE, Mathalon, DH, Rosenbloom, MJ, Lim, KO, Pfefferbaum, A (2000 b). Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia. Archives of General Psychiatry 57, 894–902.CrossRefGoogle ScholarPubMed
Sullivan, EV, Pfefferbaum, A (2005). Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology 180, 583–594.CrossRefGoogle ScholarPubMed
Taki, Y, Goto, R, Evans, A, Zijdenbos, A, Neelin, P, Lerch, J, Sato, K, Ono, S, Kinomura, S, Nakagawa, M, Sugiura, M, Watanabe, J, Kawashima, R, Fukuda, H (2004). Voxel-based morphometry of human brain with age and cerebrovascular risk factors. Neurobiology of Aging 25, 455–463.CrossRefGoogle ScholarPubMed
Thayer, RE, Hagerty, SL, Sabbineni, A, Claus, ED, Hutchison, KE, Weiland, BJ (2016). Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry. Human Brain Mapping 37, 2276–2292.CrossRefGoogle ScholarPubMed
van der Werf-Eldering, MJ, Burger, H, Holthausen, EA, Aleman, A, Nolen, WA (2010). Cognitive functioning in patients with bipolar disorder: association with depressive symptoms and alcohol use. PLoS ONE 5, e13032.CrossRefGoogle ScholarPubMed
van Erp, TG, Hibar, DP, Rasmussen, JM, Glahn, DC, Pearlson, GD, Andreassen, OA, Agartz, I, Westlye, LT, Haukvik, UK, Dale, AM, Melle, I, Hartberg, CB, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, DW, Cannon, DM, Corvin, A, Machielsen, MW, Koenders, L, de Haan, L, Veltman, DJ, Satterthwaite, TD, Wolf, DH, Gur, RC, Gur, RE, Potkin, SG, Mathalon, DH, Mueller, BA, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, VD, Bockholt, HJ, Sponheim, SR, Shoemaker, JM, van Haren, NE, Pol, HE, Ophoff, RA, Kahn, RS, Roiz-Santianez, R, Crespo-Facorro, B, Wang, L, Alpert, KI, Jonsson, EG, Dimitrova, R, Bois, C, Whalley, HC, McIntosh, AM, Lawrie, SM, Hashimoto, R, Thompson, PM, Turner, JA (2015). Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium. Molecular Psychiatry 21, 547–553.CrossRefGoogle ScholarPubMed
Welch, KA, Carson, A, Lawrie, SM (2013). Brain structure in adolescents and young adults with alcohol problems: systematic review of imaging studies. Alcohol and Alcoholism 48, 433–444.CrossRefGoogle Scholar
Wobrock, T, Falkai, P, Schneider-Axmann, T, Frommann, N, Wolwer, W, Gaebel, W (2009). Effects of abstinence on brain morphology in alcoholism: a MRI study. European Archives of Psychiatry and Clinical Neuroscience 259, 143–150.CrossRefGoogle ScholarPubMed
WHO Global Information System on Alcohol and Health (2010). (http://gamapserver.who.int/gho/interactive_charts/gisah/consumption_adult/atlas.html). World Health Organization. Accessed 3 October 2016.Google Scholar
Young, RC, Biggs, JT, Ziegler, VE, Meyer, DA (1978). A rating scale for mania: reliability, validity and sensitivity. British Journal of Psychiatry 133, 429–435.CrossRefGoogle ScholarPubMed
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