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Adenosine 3′5′ cyclic monophosphate metabolism in patients with severe depressive illness1

Published online by Cambridge University Press:  09 July 2009

David B. Jarrett ,
Barbara Newell ,
Brian Davies  and
John P. Coghlan
David B. Jarrett*
Affiliation:
Department of Psychiatry, University of Melbourne, Australia
Barbara Newell
Affiliation:
Department of Psychiatry, University of Melbourne, Australia
Brian Davies
Affiliation:
Department of Psychiatry, University of Melbourne, Australia
John P. Coghlan
Affiliation:
Howard Florey Institute of Experimental Medicine and Physiology, Australia
*
2Address for correspondence: Dr D. B. Jarrett, NIAMDD/DB, Building 10, Room 8S-243, National Institute of Health, Bethesda, Maryland 20014, USA.
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Synopsis

The daily excretion of adenosine 3′5′ cyclic monophosphate (c-AMP) in a group of 19 patients with a severe depressive illness was found to be significantly decreased when compared with that from a group of euthymic patients being treated for other disorders in the same ward. The daily excretion of the depressed patients increased during the period of treatment and recovery from the illness. Treatment with a tricyclic antidepressant caused a greater increase than electroconvulsive treatment (ECT). There was no difference between the mean plasma c-AMP concentration of the depressed and euthymic groups. The mean CSF c-AMP concentration was not different from the mean plasma c-AMP concentration in 12 patients with severe depression. There was no direct correlation between the CSF and plasma concentrations within patients. It was concluded that there may be a reversible disturbance in the renal metabolism of c-AMP in patients with severe depression.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 1 , February 1977 , pp. 93 - 101
Copyright
Copyright © Cambridge University Press 1977

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Footnotes

1

Address for reprints: Department of Psychiatry, University of Melbourne, P.O. Royal Melbourne Hospital, Victoria 3050, Australia.

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