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Absorption of lithium following administration of slow-release and conventional preparations

Published online by Cambridge University Press:  09 July 2009

Stephen Tyrer ,
R. P. Hullin ,
N. J. Birch  and
J. C. Goodwin
Stephen Tyrer
Affiliation:
Departments of Psychiatry and Biochemistry, University of Leeds, Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, Yorks
R. P. Hullin*
Affiliation:
Departments of Psychiatry and Biochemistry, University of Leeds, Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, Yorks
N. J. Birch
Affiliation:
Departments of Psychiatry and Biochemistry, University of Leeds, Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, Yorks
J. C. Goodwin
Affiliation:
Departments of Psychiatry and Biochemistry, University of Leeds, Regional Metabolic Research Unit, High Royds Hospital, Menston, Ilkley, Yorks
*
2Address for correspondence: Dr R. P. Hullin, High Royds Hospital, Menston, Ilkley, W. Yorkshire.
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Synopsis

The plasma lithium levels of 18 subjects receiving one standard and two slow-release preparations of lithium carbonate were measured at frequent intervals during the 24 hours following oral ingestion of a single dose of the drug. Although the slow-release tablets showed slow-release in vitro, this was not so in vivo. One slow-release preparation, in particular, was ineffectively absorbed by some subjects. There was no difference in the rate of absorption and excretion between the other slow-release product and the standard BP preparation. The implications of the results are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 1 , February 1976 , pp. 51 - 58
Copyright
Copyright © Cambridge University Press 1976

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