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The therapeutic effect of ascorbic acid and EDTA in manic-depressive psychosis: double-blind comparisons with standard treatments

Published online by Cambridge University Press:  09 July 2009

D. S. G. Kay ,
G. J. Naylor ,
A. H. W. Smith  and
C. Greenwood
D. S. G. Kay
Affiliation:
Department of Psychiatry, The University, Dundee
G. J. Naylor*
Affiliation:
Department of Psychiatry, The University, Dundee
A. H. W. Smith
Affiliation:
Department of Psychiatry, The University, Dundee
C. Greenwood
Affiliation:
Department of Psychiatry, The University, Dundee
*
1Address for correspondence: Dr G. J. Naylor, Department of Psychiatry, Ninewells Hospital and Medical School, Dundee DD1 9SY.
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Synopsis

The effect of ascorbic acid and ethylene diamine tetra acetic acid (EDTA) in the treatment of manic-depressive psychosis was compared, using double-blind procedures, with recognized treatment regimes. There was no significant difference between the response of depressed patients to amitriptyline or ascorbic acid and EDTA. Manic patients responded significantly better to lithium than to ascorbic acid and EDTA. These results are in keeping with the suggestion that vanadium may be of aetiological importance in depressive psychosis, but do not support such a suggestion for mania.

Type
Research Article
Information
Psychological Medicine , Volume 14 , Issue 3 , August 1984 , pp. 533 - 539
Copyright
Copyright © Cambridge University Press 1984

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References

REFERENCES

Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. & Erbaugh, J. (1961). An inventory for measuring depression. Archives of General Psychiatry 4, 561–569.CrossRefGoogle ScholarPubMed
Beigel, A. & Murphy, D. L. (1971). Assessing clinical characteristics of the manic state. American Journal of Psychiatry 128, 688–694.CrossRefGoogle ScholarPubMed
Choi, S. J., Taylor, M. A. & Abrams, R. (1977). Depression, ECT and erythocyteadenosine-triphosphatase activity. Biological Psychiatry 12, 75–81.Google Scholar
Coppen, A. & Shaw, D. M. (1963). Mineral metabolism in melancholia. British Medical Journal ii, 1439–1444.CrossRefGoogle Scholar
Coppen, A., Shaw, D. M., Malleson, A. & Costain, R. (1966). Mineral metabolism in mania. British Medical Journal i, 71–75.CrossRefGoogle Scholar
Dick, D. A. T., Naylor, G. J. & Dick, E. G. (1982). Plasma vanadium concentration in manic depressive illness. Psychological Medicine 12, 533–537.CrossRefGoogle ScholarPubMed
Hamilton, M. (1976). Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278–296.CrossRefGoogle Scholar
Hesketh, J. E., Glen, A. I. M. & Reading, H. W. (1977). Effects of potassium and lithium on sodium transport from blood to cerebrospinal fluid. Journal of Neurochemistry 28, 1401–1402.CrossRefGoogle ScholarPubMed
Hokin-Naeverson, M., Speigel, D. A. & Lewis, W. C. (1974). Deficiency of erythrocyte sodium pump activity in bipolar manic depressive psychosis. Life Sciences 15, 1739–1748.CrossRefGoogle Scholar
Naylor, G. J. & Smith, A. H. W. (1981). Vanadium, a possible aetiological factor in manic depressive illness. Psychological Medicine 11, 249–256.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T.Le Poidevin, D. & White, S. F. (1973). Erythrocyte membrane cation carrier in depressive illness. Psychological Medicine 3, 502–508.CrossRefGoogle ScholarPubMed
Naylor, G. J., Dick, D. A. T., Dick, E. G., Worrall, E. P., Peet, M., Dick, P. & Boardman, L. J. (1976). Erythrocyte membrane cation carrier in mania. Psychological Medicine 6, 659–663.CrossRefGoogle ScholarPubMed
Naylor, G. J., Smith, A. H. W., Dick, E. G., Dick, D. A. T., McHarg, A. & Chambers, C. A. (1980). Erythrocyte membrane cation carrier in manic depressive psychosis. Psychological Medicine 10, 521–525.CrossRefGoogle ScholarPubMed
Naylor, G. J., Smith, A. H. W., Bryce-Smith, D., & Ward, I. (1984). Tissue vanadium levels in manic-depressive psychosis. Psychological Medicine 14 (in the press).CrossRefGoogle ScholarPubMed
Post, R. L., Merritt, C. R., Kinsolving, C. R. & Albright, C. D. (1960). Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte. Journal of Biological Chemistry 235, 1796–1802.CrossRefGoogle ScholarPubMed
Smith, A. H. W., Naylor, G. J. & Moody, J. P. (1978). Placebo controlled double blind trial of mianserin hydrochloride. British Journal of Clinical Pharmacology 5, 67S–70S.CrossRefGoogle ScholarPubMed
Worrall, E. P., Moody, J. P., Peet, M., Dick, P., Smith, A., Chambers, C., Adams, M. & Naylor, G. J. (1979). Controlled studies of the acute antidepressant effects of lithium. British Journal of Psychiatry 135, 255–262.CrossRefGoogle ScholarPubMed