Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-19T13:27:56.826Z Has data issue: false hasContentIssue false
  • English
  • Français

A study of genetic linkage in schizophrenia

Published online by Cambridge University Press:  09 July 2009

B. Andrew ,
D. C. Watt ,
C. Gillespie  and
H. Chapel
B. Andrew
Affiliation:
St John's Hospital, Stone, Aylesbury
D. C. Watt*
Affiliation:
St John's Hospital, Stone, Aylesbury
C. Gillespie
Affiliation:
St John's Hospital, Stone, Aylesbury
H. Chapel
Affiliation:
St John's Hospital, Stone, Aylesbury
*
1Address for correspondence: Dr D. C. Watt, 7 Churchway, Stone, Aylesbury, Bucks HP17 8RG.
Get access Rights & Permissions [Opens in a new window]

Synopsis

Families with more than one member affected by schizophrenia were identified and their members were interviewed. Four standardized diagnostic definitions (PSE, DSM-III, ICD-9, Feighner) were applied to all subjects who were classified as schizophrenic or not schizophrenic according to each definition. Non-schizophrenic psychiatric disorders which have been shown to be familially associated with schizophrenia were also identified. Twenty blood markers were ascertained for all subjects and evidence of co-segregation with schizophrenia was sought. No selective segregation was found and therefore there was no evidence suggesting linkage or supporting a monogenic theory of transmission of susceptibility to schizophrenia.

Type
Research Article
Information
Psychological Medicine , Volume 17 , Issue 2 , May 1987 , pp. 363 - 370
Copyright
Copyright © Cambridge University Press 1987

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders (3rd edn). APA: Washington, D.C.Google Scholar
Baldwin, J. A. (1972). The Oxford Record Linkage Study as a medical information system. Proceedings of the Royal Society of Medicine 65, 237–239.CrossRefGoogle ScholarPubMed
Brockington, I., Kendell, R. & Leff, J. (1978). Definitions of schizophrenia: concordance and prediction of Outcome. Psychological Medicine 8, 387–398.CrossRefGoogle ScholarPubMed
Edwards, J. H. (1972). The genetical basis of schizophrenia. In Genetic Factors in ‘Schizophrenia’ (ed. Kaplan, A.), pp. 310–314. Charles Thomas, Springfield, Ill.Google Scholar
Elston, R. C., Kringlen, E. & Namboodiri, K. K. (1973). Possible linkage relationships between certain blood groups and schizophrenia or other psychoses. Behavioural Genetics 3, 101–106.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972). Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry 26, 57–63.CrossRefGoogle ScholarPubMed
Gottesman, I. & Shields, J. (1972). Schizophrenia and Genetics. Academic Press: New York.Google Scholar
Gottesman, I. & Shields, J. (1982). Schizophrenia: the Epigenetic Puzzle. Cambridge University Press: Cambridge.Google Scholar
Green, J. R. & Woodrow, J. C. (1977). Sibling method for detecting HLA-linked genes in disease. Tissue Antigens 9, 31–35.CrossRefGoogle ScholarPubMed
Kendler, K. S. & Gruenberg, A. M. (1982). The genetic relationship between paranoid personality disorder and the schizophrenia spectrum disorders. American Journal of Psychiatry 139, 1185–1186.Google Scholar
Kendler, K. S., Gruenberg, A. M. & Strauss, J. S. (1981). An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia. II. The relationship between schizotypal personality disorder and schizophrenia. Archives of General Psychiatry 38, 982–984.CrossRefGoogle Scholar
Kety, S., Rosenthal, D., Wender, P. & Schulsinger, F. (1968). The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. In The Transmission of Schizophrenia (ed. Rosenthal, D. and Kety, S. S.), pp. 345–362. Pergamon: Oxford.Google Scholar
McGuffin, P., Festenstein, H. & Murray, R. (1983). A family study of HLA antigens and other genetic markers in schizophrenia. Psychological Medicine 13, 31–43.Google Scholar
Morton, N. (1955). The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. American Journal of Human Genetics 8, 80–96.Google Scholar
Sturt, E. & McGuffin, P. (1985). Can linkage and marker association resolve the genetic aetiology of psychiatric disorders? Review and argument. Psychological Medicine 15, 455–456.CrossRefGoogle ScholarPubMed
Thompson, E. A., Kravitz, K., Hill, J. & Skolnick, M. H. (1978). Linkage and the power of a pedigree structure. In Genetic Epidemiology (ed. Morton, N. and Chung, C.), pp. 247–253. Academic Press: London.Google Scholar
Turner, W. J. (1979). Genetic markers for schizotaxia. Biological Psychiatry 14, 177–206.Google ScholarPubMed
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar
World Health Organization (1978). Mental Disorders: Glossary and Guide to their Classification in Accordance with Revision of the International Classification of Diseases. WHO: Geneva.Google Scholar