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Self-reported childhood trauma correlates with schizotypal measures in schizophrenia but not bipolar pedigrees

Published online by Cambridge University Press:  30 June 2008

F. Schürhoff ,
A. Laguerre ,
H. Fisher ,
B. Etain ,
A. Méary ,
C. Soussy ,
A. Szöke  and
M. Leboyer
F. Schürhoff*
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France INSERM Unité 841, IMRB, Département de Génétique, Equipe 15, Créteil, France Université Paris 12, Faculté de Médecine, IFR10, Créteil, France
A. Laguerre
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France INSERM Unité 841, IMRB, Département de Génétique, Equipe 15, Créteil, France Université Paris 12, Faculté de Médecine, IFR10, Créteil, France
H. Fisher
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
B. Etain
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France INSERM Unité 841, IMRB, Département de Génétique, Equipe 15, Créteil, France Université Paris 12, Faculté de Médecine, IFR10, Créteil, France
A. Méary
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France INSERM Unité 841, IMRB, Département de Génétique, Equipe 15, Créteil, France Université Paris 12, Faculté de Médecine, IFR10, Créteil, France
C. Soussy
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France
A. Szöke
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France INSERM Unité 841, IMRB, Département de Génétique, Equipe 15, Créteil, France Université Paris 12, Faculté de Médecine, IFR10, Créteil, France
M. Leboyer
Affiliation:
AP-HP, Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, France INSERM Unité 841, IMRB, Département de Génétique, Equipe 15, Créteil, France Université Paris 12, Faculté de Médecine, IFR10, Créteil, France
*
*Address for correspondence: F. Schürhoff, M.D., Ph.D., Pôle Universitaire de Psychiatrie, Hôpital Albert Chenevier, 40 rue Mesly, 94 000 Creteil, France. (Email: [email protected])
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Abstract

Background

Strong evidence supports the association between childhood trauma and psychotic disorders. In two different high-risk populations, we looked for a correlation between the magnitude of schizotypal dimensions and the importance of self-reported childhood trauma.

Method

A sample of 138 unaffected first-degree relatives was recruited (67 relatives of schizophrenic probands and 71 relatives of bipolar probands). The relationship between schizotypal dimensions and childhood trauma scores was analyzed by partial correlations.

Results

A positive correlation was found between childhood trauma scores and total schizotypal scores in first-degree relatives of schizophrenic subjects but not in first-degree relatives of bipolar probands. This correlation was primarily due to a strong association with the positive dimension of schizotypy.

Conclusions

The significant correlation between childhood trauma and schizotypal dimensions in subjects at high genetic risk for schizophrenia suggests that susceptibility genes for schizophrenia may interact with childhood trauma to induce the emergence of schizotypal dimensions, mainly positive psychotic features.

Keywords

BipolarG×Eschizophreniaschizotypytrauma
Type
Original Articles
Information
Psychological Medicine , Volume 39 , Issue 3 , March 2009 , pp. 365 - 370
Copyright
Copyright © 2008 Cambridge University Press

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References

Berenbaum, H, Valera, EM, Kerns, JG (2003). Psychological trauma and schizotypal symptoms. Schizophrenia Bulletin 29, 143–152.Google Scholar
Bernstein, DP, Fink, L (1998). Childhood Trauma Questionnaire: A Retrospective Self-Report Manual. The Psychological Corporation: San Antonio, TX.Google Scholar
Berrettini, W (2003). Evidence for shared susceptibility in bipolar disorder and schizophrenia. American Journal of Medical Genetics (Part C) 123, 59–64.Google Scholar
Caspi, A, Moffitt, TE, Cannon, M, McLay, J, Murray, R, Harrington, H, Taylor, A, Arseneault, L, Williams, B, Braithwaite, A, Poulton, R, Craig, IW (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase: longitudinal evidence of a gene×environment interaction. Biological Psychiatry 57, 1117–1127.CrossRefGoogle Scholar
Caspi, A, Sugden, K, Moffitt, TE, Taylor, A, Craig, IW, Harrington, H, McLay, J, Mill, J, Martin, J, Braithwaite, A, Poulton, R (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386–389.CrossRefGoogle ScholarPubMed
Corbett, R, Zhou, L, Sorensen, SM, Mondadori, C (1999). Animal models of negative symptoms: M100907 antagonizes PCP-induced immobility in a forced swim test in mice. Neuropsychopharmacology 21, S211–S218.Google Scholar
Dumas, P, Bouafia, S, Gutknecht, C, Saoud, M, Dalery, J, d'Amato, T (2000). Validation of the French version of the Raine Schizotypal Personality Questionnaire – categorical and dimensional approach to schizotypal personality traits in a normal student population. Encephale 26, 23–29.Google Scholar
Hammersley, P, Dias, A, Todd, G, Bowen-Jones, K, Reilly, B, Bentall, RP (2003). Childhood trauma and hallucinations in bipolar affective disorder: preliminary investigation. British Journal of Psychiatry 182, 543–547.Google Scholar
Irwin, HJ (2001). The relationship between dissociative tendencies and schizotypy: an artefact of childhood trauma? Journal of Clinical Psychology 57, 331–342.CrossRefGoogle Scholar
Kahn, RS, Khoury, J, Nichols, WC, Lanphear, BP (2003). Role of the dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. Journal of Pediatrics 143, 104–110.Google Scholar
Kendler, KS, Eaves, LJ (1986). Models for the joint effect of genotype and environment on liability to psychiatric illness. American Journal of Psychiatry 143, 279–289.Google ScholarPubMed
Kendler, KS, Kuhn, JW, Vittum, J, Prescott, CA, Riley, B (2005). The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression. Archives of General Psychiatry 62, 529–535.Google Scholar
Kety, SS, Wender, PH, Jacobsen, B, Ingraham, LJ, Jansson, L, Faber, B, Kinney, DK (1994). Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen study in the rest of Denmark. Archives of General Psychiatry 51, 442–455.CrossRefGoogle ScholarPubMed
Lysaker, PH, Meyer, PS, Evans, JD, Clementz, CA, Marks, KA (2001). Childhood sexual trauma and psychosocial functioning in adults with schizophrenia. Psychiatry Services 52, 1485–1488.CrossRefGoogle ScholarPubMed
Mata, I, Mataix-Cols, D, Peralta, V (2005). Schizotypal Personality Questionnaire-Brief: factor structure and influence of sex and age in a nonclinical population. Personality and Individual Differences 38, 1183–1192.Google Scholar
Moffitt, TE, Caspi, A, Rutter, M (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry 62, 473–481.CrossRefGoogle ScholarPubMed
Neria, Y, Bromet, EJ, Carlson, GA, Naz, B (2005). Assaultive trauma and illness course in psychotic bipolar disorder: findings from the Suffolk County Mental Health Project. Acta Psychiatrica Scandinavica 111, 380–383.CrossRefGoogle ScholarPubMed
Nurnberger, JI Jr., Blehar, MC, Kaufmann, CA, York-Cooler, C, Simpson, SG, Harkavy-Friedman, J, Severe, J, Malaspina, D, Reich, T (1994). Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry 51, 849–859.CrossRefGoogle ScholarPubMed
Paquette, D, Laporte, L, Bigras, M, Zoccolillo, M (2004). Validation of the French version of the CTQ and prevalence of the history of maltreatment. Santé Mentale au Quebec 29, 201–220.Google Scholar
Pichot, P, Lebeaux, MO, Penhouët, C, Simon, M (1993). Estimation of the premorbid intellectual level with the WAIS-R. A comparison between the Barona method and Wechsler's Deterioration index [in French]. Revue Européenne de Psychologie Appliquée 43, 291–301.Google Scholar
Preisig, M, Fenton, BT, Matthey, ML, Berney, A, Ferrero, F (1999). Diagnostic Interview for Genetic Studies (DIGS): inter-rater and test–retest reliability of the French version. European Archives of Psychiatry and Clinical Neuroscience 249, 174–179.CrossRefGoogle ScholarPubMed
Raine, A (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 17, 555–564.Google Scholar
Read, J, Argyle, N (1999). Hallucinations, delusions and thought disorders among adult psychiatric inpatients with a history of child abuse. Psychiatry Services 50, 1467–1472.Google Scholar
Read, J, Van Os, J, Morrison, AP, Ross, CA (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica 112, 330–350.CrossRefGoogle ScholarPubMed
Resnick, S, Bond, G, Mueser, K (2003). Trauma and PTSD in people with schizophrenia. Journal of Abnormal Psychology 112, 415–423.CrossRefGoogle ScholarPubMed
Schürhoff, F, Laguerre, A, Szöke, A, Méary, A, Leboyer, M (2005). Schizotypal dimensions: continuity between schizophrenia and bipolar disorders. Schizophrenia Research 80, 235–242.Google Scholar
Schürhoff, F, Szöke, A, Méary, A, Bellivier, F, Rouillon, F, Pauls, D, Leboyer, M (2003). Familial aggregation of delusional proneness in schizophrenia and bipolar pedigrees. American Journal of Psychiatry 160, 1313–1319.CrossRefGoogle ScholarPubMed
Spauwen, J, Krabbendam, L, Lieb, R, Wittchen, HU, Jansen, JA, Van Os, J (2006). Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness. British Journal of Psychiatry 188, 527–533.Google Scholar
Van Os, J, Gilvarry, C, Bale, R, Van Horn, E, Tattan, T, White, I, Murray, R (2002). A comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group. Psychological Medicine 29, 595–606.CrossRefGoogle Scholar
Venables, PH, Bailes, K (1994). The structure of schizotypy, its relation to subdiagnoses of schizophrenia and to sex and age. British Journal of Clinical Psychology 33, 277–294.Google Scholar
Vollema, MG, Postma, B (2002). Neurocognitive correlates of schizotypy in first degree relatives of schizophrenia patients. Schizophrenia Bulletin 28, 367–377.Google Scholar
Yen, S, Shea, MT, Battle, CL, Johnson, DM, Zlotnick, C, Dolan-Sewell, R, Skodol, AE, Grilo, CM, Gunderson, JG, Sanislow, CA, Zanarini, MC, Bender, DS, Rettew, JB, McGlashan, TH (2002). Traumatic exposure and posttraumatic stress disorder in borderline, schizotypal, avoidant, and obsessive-compulsive personality disorders: findings from the collaborative longitudinal personality disorders study. Journal of Nervous and Mental Disease 190, 510–518.CrossRefGoogle Scholar