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Psychiatric morbidity in patients with Parkinson's disease

Published online by Cambridge University Press:  09 July 2009

R. G. Brown*
Affiliation:
Medical Research Council Human Movement and Balance Unit, National Hospital, Queen Square, London and Academic Unit, St Bernard Wing, Ealing Hospital, Uxbridge Road, Southall, Middlesex
B. MacCarthy
Affiliation:
Medical Research Council Human Movement and Balance Unit, National Hospital, Queen Square, London and Academic Unit, St Bernard Wing, Ealing Hospital, Uxbridge Road, Southall, Middlesex
*
1Address for correspondence: Dr R. G. Brown, MRC Human Movement and Balance Unit, National Hospital, Queen Square, London WCIN 3BG.

Synopsis

Forty patients with Parkinson's disease underwent a detailed assessment of their psychiatric state using a standardized, semi-structured interview, the Present State Examination. Analysis of the interviews yielded a profile of depressive and neurotic syndromes. Comparing the results with population norms, however, revealed that the patients were distinguished only by high levels of depressed mood and loss of interest and poor concentration. In the majority of patients the range and severity of symptoms fell below the criteria for ‘caseness’. Only four patients could be allocated to an ICD-9 class, two to ‘ neurotic depression’, one to ‘ anxiety state’ and one to ‘ phobic state’. This rate was almost identical to that found in the general population. Broader indices of psychiatric morbidity were related to the patients' levels of disability and cognitive function.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1990

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References

American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental disorders, 3rd edn.American Psychiatric Association: Washington, DC.Google Scholar
Bebbington, P., Hurry, J., Tennant, C., Sturt, E. & Wing, J. K. (1981). Epidemiology of mental disorders in Camberwell. Psychological Medicine 11, 561579.CrossRefGoogle ScholarPubMed
Beck, A. T. & Beamesderfer, A. (1974). Assessment of depression: the depression inventory. In Psychological Measurements in Psychopharmacology, vol. 7 (ed. Pichot, P.). Kagel-Basel: Paris.Google Scholar
Brown, R. G., MacCarthy, B., Gotham, A.-M., Der, G. & Marsden, C. D. (1988). Depression and disability in Parkinson's disease: a follow-up of 132 cases. Psychological Medicine 18, 4955.CrossRefGoogle ScholarPubMed
Brown, R. G., MacCarthy, B., Jahanshahi, M. & Marsden, C. D. (1989). The accuracy of self-reported disability in patients with parkinsonism. Archives of Neurology 46, 955959.CrossRefGoogle ScholarPubMed
Celesia, G. G. & Wanamaker, W. M. (1972). Psychiatric disturbances in parkinsonism. Diseases of the Nervous System 33, 577583.Google Scholar
Cooper, J. E., Kendell, R. E., Gurland, B. J., Sharpe, L., Copeland, J. R. M. & Simon, R. (1972). Psychiatric Diagnosis in London and New York. Oxford University Press: Oxford.Google Scholar
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975). ‘Minimental state’: a practical method for grading the mental state of patients for the clinician. Journal of Psychiatric Research 12, 189198.CrossRefGoogle Scholar
General Practice Research Unit (1970). The General Practice Research Unit Interview Schedule. Institute of Psychiatry: London.Google Scholar
Goldberg, D. (1972). The Detection of Psychiatric Illness by Questionnaire. Maudsley Monograph no. 21. Oxford University Press: London.Google Scholar
Gotham, A.-M., Brown, R. G. & Marsden, C. D. (1986). Depression in Parkinson's disease: a quantitative and qualitative analysis. Journal of Neurology, Neurosurgery and Psychiatry 49, 381389.CrossRefGoogle ScholarPubMed
Hamilton, M. A. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 5662.CrossRefGoogle ScholarPubMed
Hathaway, S. & McKinley, J. (1951). The Minnesota Multiphasic Personality Inventory Manual. University of Minnesota Press: Minneapolis.Google Scholar
Hoehn, M. M. & Yahr, M. D. (1967). Parkinsonism: onset, progression and mortality. Neurology (Minneapolis) 17, 427442.CrossRefGoogle ScholarPubMed
Marsh, G. G. & Markham, C. H. (1973). Does levodopa alter depression and psychopathology in parkinsonian patients? Journal of Neurology, Neurosurgery and Psychiatry 36, 925935.CrossRefGoogle Scholar
Mayeux, R., Stern, Y., Rosen, J. & Leventhal, J. (1981). Depression, intellectual impairment and Parkinson's disease. Neurology 31, 645650.CrossRefGoogle Scholar
Mayeux, R., Williams, J. B. W., Stern, Y. & Côté, L. (1984). Depression in Parkinson's disease. In Advances in Neurology, vol. 40, (ed. Hassler, R. G. & Christ, J. F.), pp. 241250. Raven Press: New York.Google Scholar
Mindham, R. H. S., Marsden, C. D. & Parkes, J. D. (1976). Psychiatric symptoms during L-dopa therapy for Parkinson's disease and their relationship to physical disability. Psychological Medicine 6, 2333.CrossRefGoogle ScholarPubMed
OPCS (1981). Classification of Occupation, 1981. HMSO: London.Google Scholar
Orley, J. & Wing, J. K. (1979). Psychiatric disorders in two African villages. Archives of General Psychiatry 36, 513520.CrossRefGoogle ScholarPubMed
Parkes, J. D. (1981). Adverse effects of antiparkinsonian drugs. Drugs 21, 341353.CrossRefGoogle ScholarPubMed
Quinn, N. & Hussain, F. A. (1986). Parkinson's disease. British Medical Journal 293, 379382.CrossRefGoogle ScholarPubMed
Spielberger, C. D., Gorsuch, R. L. & Lushene, R. E. (1970). Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press: Palo Alto, California.Google Scholar
Sturt, E. (1981). Hierarchical patterns of distribution of psychiatric symptoms. Psychological Medicine 11, 783794.CrossRefGoogle ScholarPubMed
Wing, J. K. (1983). Use and misuse of the PSE. British Journal of Psychiatry 143, 111117.CrossRefGoogle ScholarPubMed
Wing, J. K., Babor, T., Breugha, T., Burke, J., Cooper, J., Griel, R., Jablensky, A., Regier, D. & Sartorius, N. (1989). SCAN: Schedules for Assessment in Neuropsychiatry. Archives of General Psychiatry (in the press).Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974). The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge.Google Scholar
World Health Organization (1973). The International Pilot Study on Schizophrenia, vol. 1. WHO: Geneva.Google Scholar
World Health Organization (1978). Mental Disorders: Glossary and Guide to their Classification in Accordance with the Ninth Revision of the International Classification of Diseases. WHO: Geneva.Google Scholar
World Health Organization (1987). International Classification of Diseases. Version 10. WHO: Geneva.Google Scholar