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Psychiatric ‘diseases’ versus behavioral disorders and degree of genetic influence

Published online by Cambridge University Press:  12 May 2010

O. J. Bienvenu ,
D. S. Davydow  and
K. S. Kendler
O. J. Bienvenu*
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
D. S. Davydow
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
K. S. Kendler
Affiliation:
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
*
*Address for correspondence: Dr O. J. Bienvenu, Johns Hopkins University, 600 N. Wolfe St., Meyer 115, Baltimore, MD 21287, USA. (Email: [email protected])
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Abstract

Background

Psychiatric conditions in which symptoms arise involuntarily (‘diseases’) might be assumed to be more heritable than those in which choices are essential (behavioral disorders). We sought to determine whether psychiatric ‘diseases’ (Alzheimer's disease, schizophrenia, and mood and anxiety disorders) are more heritable than behavioral disorders (substance use disorders and anorexia nervosa).

Method

We reviewed the literature for recent quantitative summaries of heritabilities. When these were unavailable, we calculated weighted mean heritabilities from twin studies meeting modern methological standards.

Results

Heritability summary estimates were as follows: bipolar disorder (85%), schizophrenia (81%), Alzheimer's disease (75%), cocaine use disorder (72%), anorexia nervosa (60%), alcohol dependence (56%), sedative use disorder (51%), cannabis use disorder (48%), panic disorder (43%), stimulant use disorder (40%), major depressive disorder (37%), and generalized anxiety disorder (28%).

Conclusions

No systematic relationship exists between the disease-like character of a psychiatric disorder and its heritability; many behavioral disorders seem to be more heritable than conditions commonly construed as diseases. These results suggest an error in ‘common-sense’ assumptions about the etiology of psychiatric disorders. That is, among psychiatric disorders, there is no close relationship between the strength of genetic influences and the etiologic importance of volitional processes.

Keywords

Behaviordiseasegenetic epidemiologygenetics
Type
Review Article
Information
Psychological Medicine , Volume 41 , Issue 1 , January 2011 , pp. 33 - 40
Copyright
Copyright © Cambridge University Press 2010

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