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Prediction of clinical course of bipolar manic depressive illness treated with lithium

Published online by Cambridge University Press:  09 July 2009

B. B. Johnston ,
G. J. Naylor ,
E. G. Dick ,
S. E. Hopwood  and
D. A. T. Dick
B. B. Johnston*
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
G. J. Naylor
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
E. G. Dick
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
S. E. Hopwood
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
D. A. T. Dick
Affiliation:
Royal Dundee Liff Hospital, Dundee; Ninewells Hospital and Medical School, Dundee; Department of Anatomy, University of Dundee
*
1Address for correspondence: Dr B. B. Johnston, Consultant Psychiatrist, Stratheden Hospital, Cupar, Fife.
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Synopsis

A group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na–K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na–K ATPase activity.

Type
Research Article
Information
Psychological Medicine , Volume 10 , Issue 2 , May 1980 , pp. 329 - 334
Copyright
Copyright © Cambridge University Press 1980

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