Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-25T08:11:34.460Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma concentrations of tryptophan and other amino acids in manic-depressive patients1

Published online by Cambridge University Press:  09 July 2009

Jancis R. Rees ,
M. N. E. Allsopp  and
R. P. Hullin
Jancis R. Rees
Affiliation:
Department of Biochemistry, University of Leeds
M. N. E. Allsopp
Affiliation:
Department of Biochemistry, University of Leeds
R. P. Hullin*
Affiliation:
Department of Biochemistry, University of Leeds
*
2Address for correspondence: Dr. R. P. Hullin, Department of Biochemistry, 9 Hyde Terrace, Leeds LS2 9LS.
Get access Rights & Permissions [Opens in a new window]

Sysnopsis

Plasma tryptophan concentrations were determined in serial blood samples from a short cycle (two to three day) manic-depressive patient and four manic-depressive patients with longer (60 day) affective cycles. Tryptophan levels varied significantly with affective state in the short cycle patient and one of the longer cycle patients. Correlation in the short cycle patient was better with blood samples taken at 3 p.m. than at 9 a.m.

Type
Preliminary communication
Information
Psychological Medicine , Volume 4 , Issue 3 , August 1974 , pp. 334 - 337
Copyright
Copyright © Cambridge University Press 1974

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

The work was supported by an M.R.C. long-term programme grant to R. P. Hullin.

References

REFERENCES

Broadhurst, A. D. (1970). L-tryptophan versus E.C.T. Lancet, 1, 1392–1393.Google Scholar
Chase, T. N., and Murphy, D. L. (1973). Serotonin and central nervous System function. Annual Review of Pharmacology, 13, 181–197.CrossRefGoogle ScholarPubMed
Coppen, A. (1972). Indoleamines and affective disorders. Journal of Psychiatric Research, 9, 163–171.CrossRefGoogle ScholarPubMed
Coppen, A., Eccleston, E. G., and Peet, M. (1973). Total and free tryptophan concentration in the plasma of depressive patients. Lancet, 2, 60–63.CrossRefGoogle ScholarPubMed
Davis, J. M., and Fann, W. E. (1971). Lithium. Annual Review of Pharmacology, 11, 285–302.CrossRefGoogle ScholarPubMed
Denckla, W. D., and Dewey, H. K. (1967). The determination of tryptophan in plasma, liver, and urine. Journal of Laboratory and Clinical Medicine, 69, 160–169.Google ScholarPubMed
Fernstrom, J. D., and Wurtman, R. J. (1972). Brain serotonin content: physiological regulation by plasma neutral amino acids. Science, 178, 414–416.CrossRefGoogle ScholarPubMed
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A., and Milne, H. B. (1967). Body water variations in manic-depressive psychosis. British Journal of Psychiatry, 113, 584–592.CrossRefGoogle ScholarPubMed
Jenner, F. A., Gjessing, L. R., Cox, J. R., Davies-Jones, A., Hullin, R. P., and Hanna, S. M. (1967). A manic depressive psychotic with a persistent forty-eight hour cycle. British Journal of Psychiatry, 113, 895–910.CrossRefGoogle ScholarPubMed
Knott, P. J., and Curzon, G. (1972). Free tryptophan in plasma and brain tryptophan metabolism. Nature, 239, 452–453.CrossRefGoogle ScholarPubMed
Schildkraut, J. J. (1973). Neuropharmacology of the affective disorders. Annual Review of Pharmacology, 13, 427–454.CrossRefGoogle ScholarPubMed
Schildkraut, J. J., and Kety, S. S. (1967). Biogenic amines and emotion. Science, 156, 21–30.CrossRefGoogle ScholarPubMed
Tagliamonte, A., Tagliamonte, P., Perez-Cruet, J., and Cessa, G. L. (1971). Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. Nature New Biology, 299, 125–126.CrossRefGoogle Scholar
Young, V. R., Hussein, M. A., Murray, E., and Scrimshaw, N. S. (1969). Tryptophan intake, spacing of meals, and diurnal fluctuations of plasma tryptophan in men. American Journal of Clinical Nutrition, 22, 1563–1567.CrossRefGoogle ScholarPubMed