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Personality and risk for depression in a birth cohort of 70-year-olds followed for 15 years

Published online by Cambridge University Press:  01 February 2008

P. R. Duberstein ,
S. P. Pálsson ,
M. Waern  and
I. Skoog
P. R. Duberstein*
Affiliation:
Laboratory of Personality and Development, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA
S. P. Pálsson
Affiliation:
Division of Psychiatry, Landspitali University Hospital, University of Iceland, Iceland
M. Waern
Affiliation:
Institute of Neuroscience and Physiology, Department of Psychiatry, Sahlgrenska University Hospital, Göteborg University, Sweden
I. Skoog
Affiliation:
Laboratory of Personality and Development, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA
*
*Address for correspondence: P. R. Duberstein, Ph.D., Laboratory of Personality and Development, Box PSYCH, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA. (Email: [email protected])
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Abstract

Background

The association between personality traits and the first lifetime onset of clinically significant depression has not been studied in older adults.

Method

Experienced psychiatrists conducted interviews and chart reviews at baseline and throughout the 15-year follow-up period. Survival analyses were conducted on the presence/absence of a DSM-III-R mood disorder at follow-up.

Results

There were 59 cases of first lifetime episodes of depression. Analyses showed that Neuroticism [hazard ratio (HR) per one point increase in the Maudsley Personality Inventory (MPI)=1.05, 95% confidence interval (CI) 1.02–1.08] but not Extroversion (HR 1.02, 95% CI 0.97–1.06) amplified risk for mood disorder.

Conclusions

This prospective study on a randomly sampled birth cohort of older adults showed that Neuroticism confers risk for a first lifetime episode of clinically significant depression. Findings have implications for understanding the etiology of late-life depression (LLD) and could also aid in the identification and treatment of people at risk.

Keywords

Agingbirth cohortdepressionneuroticismpersonality
Type
Original Articles
Information
Psychological Medicine , Volume 38 , Issue 5 , May 2008 , pp. 663 - 671
Copyright
Copyright © Cambridge University Press 2008

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References

Akiskal, HS, Hirschfeld, RM, Yerevanian, BI (1983). The relationship of personality to affective disorders. Archives of General Psychiatry 40, 801–810.CrossRefGoogle ScholarPubMed
APA (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. American Psychiatric Association: Washington, DC.Google Scholar
Åsberg, M, Montgomery, SA, Perris, C, Schalling, D, Sedvall, G (1978). A comprehensive psychopathological rating scale. Acta Psychiatrica Scandinavica (Suppl.) 271, 5–27.CrossRefGoogle Scholar
Åström, J, Ölander, F (1960). Maudsley Personality Inventory (MPI) in clinical practice. Nordisk Psychiatrisk Tidskrift 4, 300–311.CrossRefGoogle Scholar
Beekman, AT, Penninx, BW, Deeg, DJ, Ormel, J, Braam, AW, van Tilburg, W (1997). Depression and physical health in later life: results from the Longitudinal Aging Study Amsterdam (LASA). Journal of Affective Disorders 46, 219–231.CrossRefGoogle ScholarPubMed
Blazer, DG (2003). Depression in late life: review and commentary. Journal of Gerontology. Series A: Biological Sciences and Medical Sciences 58, 249–265.CrossRefGoogle Scholar
Blazer, DG, Hybels, CF (2004). What symptoms of predict in community-dwelling elders? Journal of the American Geriatrics Society 52, 2052–2056.CrossRefGoogle ScholarPubMed
Boyce, P, Parker, G, Barnett, B, Cooney, M, Smith, F (1991). Personality as a vulnerability factor for depression. British Journal of Psychiatry 159, 106–114.CrossRefGoogle Scholar
Brodaty, H, Luscombe, G, Parker, G, Wilhelm, K, Hickie, I, Austin, MP, Mitchell, P (2002). Early and late onset depression in old age: different aetiologies, same phenomenology. Journal of Affective Disorders 66, 225–236.CrossRefGoogle Scholar
Brugha, TS, Bebbington, PE, Jenkins, RA (1999). Difference that matters: comparisons of structured and semi-structured psychiatric diagnostic interviews in the general population. Psychological Medicine 29, 1013–1020.CrossRefGoogle ScholarPubMed
Charney, DS, Reynolds, CF III, Lewis, L, Lebowitz, BD, Sunderland, T, Alexopoulos, GS, Blazer, DG, Katz, IR, Meyers, BS, Arean, PA, Borson, S, Brown, C, Bruce, ML, Callahan, CM, Charlson, ME, Conwell, Y, Cuthbert, BN, Devanand, DP, Gibson, MJ, Gottlieb, GL, Krishnan, KR, Laden, SK, Lyketsos, CG, Mulsant, BH, Niederehe, G, Olin, JT, Oslin, DW, Pearson, J, Persky, T, Pollock, BG, Raetzman, S, Reynolds, M, Salzman, C, Schulz, R, Schwenk, TL, Scolnick, E, Unutzer, J, Weissman, MM, Young, RC, Depression and Bipolar Support Alliance (2003). Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life. Archives of General Psychiatry 60, 664–672.CrossRefGoogle ScholarPubMed
Conwell, Y, Duberstein, PR, Caine, ED (2002). Risk factors for suicide in later life. Biological Psychiatry 52, 193–204.CrossRefGoogle ScholarPubMed
Engel, GL (1977). The need for a new medical model: a challenge for biomedicine. Science 96, 129–136.CrossRefGoogle Scholar
Eysenck, HJ (1959). Manual of the Maudsley Personality Inventory. University of London Press: London.Google Scholar
Eysenck, HJ (1960). The Structure of Human Personality. Methuen: London.Google Scholar
Finch, CE, Crimmins, EM (2004). Inflammatory exposure and historical changes in human life-spans. Science 305, 1736–1739.CrossRefGoogle ScholarPubMed
Fröjdh, K, Håkansson, A, Karlsson, I, Molarius, A (2003). Deceased, disabled or depressed: a population-based 6-year follow-up study of elderly people with depression. Social Psychiatry and Psychiatric Epidemiology 38, 557–562.CrossRefGoogle ScholarPubMed
Hosmer, DW, Lemeshow, S (1999). Applied Survival Analysis: Regression Modelling of Time to Event Data. John Wiley & Sons, Inc.: New York.Google Scholar
Jensen, AR (1958). The Maudsley Personality Inventory. Acta Psychologica 14, 314–325.CrossRefGoogle Scholar
Jorm, AF (2000). Does old age reduce the risk of anxiety and depression? A review of epidemiological studies across the adult life span. Psychological Medicine 30, 11–22.CrossRefGoogle ScholarPubMed
Katon, WJ, Lin, E, Russo, J, Unutzer, J (2003). Increased medical costs of a population-based sample of depressed elderly patients. Archives of General Psychiatry 60, 897–903.CrossRefGoogle ScholarPubMed
Kay, DWK, Henderson, AS, Scott, R, Wilson, J, Rickwood, D, Grayson, DA (1985). Dementia and depression among the elderly living in the Hobart community: the effect of the diagnostic criteria on the prevalence rates. Psychological Medicine 15, 771–788.CrossRefGoogle ScholarPubMed
Kendler, KS, Gatz, M, Gardner, CO, Pedersen, NL (2006). Personality and major depression: a Swedish longitudinal, population-based study. Archives of General Psychiatry 63, 1113–1120.CrossRefGoogle Scholar
Kessing, LV, Agerbo, E, Mortensen, PB (2003). Does the impact of major stressful life events on the risk of developing depression change throughout life? Psychological Medicine 33, 1177–1184.CrossRefGoogle ScholarPubMed
Kraaij, V, Arensman, E, Spinhoven, P (2002). Negative life events and depression in elderly persons: a meta-analysis. Journal of Gerontology. Series B: Psychological Sciences and Social Sciences 57, P87–P94.CrossRefGoogle ScholarPubMed
Kraemer, HC, Kazdin, AE, Offord, DR, Kessler, RC, Jensen, PS, Kupfer, DJ (1997). Coming to terms with the terms of risk. Archives of General Psychiatry 54, 337–343.CrossRefGoogle ScholarPubMed
Krishnan, KRR (2002). Biological risk factors in late life depression. Biological Psychiatry 52, 185–192.CrossRefGoogle ScholarPubMed
Krueger, RF (1999). Personality traits in late adolescence predict mental disorders in early adulthood: a prospective epidemiological study. Journal of Personality Disorder 67, 39–65.CrossRefGoogle ScholarPubMed
Krueger, RF, Caspi, A, Moffitt, TE (2000). Epidemiological personology: the unifying role of personality in population-based research on problem behaviors. Journal of Personality 68, 967–998.CrossRefGoogle ScholarPubMed
Mulder, RT (2002). Personality pathology and treatment outcome in major depression: a review. American Journal of Psychiatry 159, 359–371.CrossRefGoogle ScholarPubMed
Nilsson, LV (1984). Incidence of severe dementia in an urban sample followed from 70 to 79 years of age. Acta Psychiatrica Scandinavica 70, 478–486.CrossRefGoogle Scholar
Ormel, J, Oldehinkel, AJ, Brilman, EI (2001). The interplay and etiological continuity of neuroticism, difficulties, and life events in the etiology of major and subsyndromal, first, and recurrent depressive episodes in later life. American Journal of Psychiatry 158, 885–891.CrossRefGoogle ScholarPubMed
Pálsson, SP, Östling, S, Skoog, I (2001). The incidence of first-onset depression in a population followed from the age of 70 to 85. Psychological Medicine 31, 1159–1168.CrossRefGoogle Scholar
Pelkonen, M, Marttunen, M, Aro, H (2003). Risk for depression: a 6-year follow-up of Finnish adolescents. Journal of Affective Disorders 77, 41–51.CrossRefGoogle ScholarPubMed
Persson, G (1980). Prevalence of mental disorders in a 70-year-old urban population. Acta Psychiatrica Scandinavica 62, 119–139.CrossRefGoogle Scholar
Persson, G, Skoog, I (1996). A prospective population study of psychosocial risk factors for late onset dementia. International Journal of Geriatric Psychiatry 11, 15–22.3.0.CO;2-5>CrossRefGoogle Scholar
Pincus, HA, Davis, WW, Moqueen, LE (1999). Subthreshold mental disorders: a review and synthesis of studies on minor depression and other ‘brand names’. British Journal of Psychiatry 174, 288–296.CrossRefGoogle ScholarPubMed
Pinquart, M, Duberstein, PR, Lyness, JM (2006). Treatments for later life depressive conditions: a meta-analytic comparison of pharmacotherapy and psychotherapy. American Journal of Psychiatry 163, 1493–1501.CrossRefGoogle ScholarPubMed
Roberts, BW, DelVecchio, WF (2000). The rank-order consistency of personality traits from childhood to old age: a quantitative review of longitudinal studies. Psychological Bulletin 126, 3–25.CrossRefGoogle ScholarPubMed
Skoog, I (2004). Psychiatric epidemiology of old age: the H70 study – the NAPE lecture 2003. Acta Psychiatrica Scandinavica 109, 4–18.CrossRefGoogle Scholar
Skoog, I, Aevarsson, O, Beskow, J, Larsson, L, Pálsson, S, Waern, M, Landahl, S, Östling, S (1996). Suicidal feelings in a population sample of non-demented 85-year-olds. American Journal of Psychiatry 53, 1015–1020.Google Scholar
Skoog, I, Nilsson, L, Landahl, S, Steen, B (1993 a). Mental disorders and the use of psychotropic drugs in an 85-year-old urban population. International Psychogeriatrics 15, 33–48.CrossRefGoogle Scholar
Skoog, I, Nilsson, L, Palmertz, B, Andreasson, LA, Svanborg, A (1993 b). A population-based study of dementia in an 85-year-old urban population. New England Journal of Medicine 328, 153–158.CrossRefGoogle Scholar
Smit, F, Ederveen, A, Cuijpers, P, Deeg, D, Beekman, A (2006). Opportunities for cost effective prevention of late life depression. An epidemiological approach. Archives of General Psychiatry 63, 290–296.CrossRefGoogle ScholarPubMed
Steunenberg, B, Beekman, AT, Deeg, DJ, Kerkhof, AJ (2006). Personality and the onset of depression in late life. Journal of Affective Disorders 92, 243–251.CrossRefGoogle ScholarPubMed
Svanborg, A (1977). Seventy-year-old people in Gothenburg. A population study in an industrialized Swedish city. II. General presentation of social and medical conditions. Acta Medica Scandinavica S611, 3–37.Google Scholar
WHO (1977). Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death. Adopted by the Twenty-ninth World Health Assembly. World Health Organization: Geneva.Google Scholar
Wilson, RS, Bennett, DA, Mendes de Leon, CF, Bienias, JL, Morris, MC, Evans, DA (2005). Distress proneness and cognitive decline in a population of older persons. Psychoneuroendocrinology 30, 11–17.CrossRefGoogle Scholar
Wittchen, H-U, Üstün, TB, Kessler, RC (1999). Diagnosing mental disorders in the community. A difference that does matter? Psychological Medicine 29, 1021–1027.CrossRefGoogle Scholar
Zonderman, AB, Herbst, JH, Schmidt, C Jr., Costa, PT Jr., McCrae, RR (1993). Depressive symptoms as a nonspecific, graded risk for psychiatric diagnoses. Journal of Abnormal Psychology 102, 544–552.CrossRefGoogle ScholarPubMed