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Perimenstrual exacerbation of symptoms in borderline personality disorder: evidence from multilevel models and the Carolina Premenstrual Assessment Scoring System

Published online by Cambridge University Press:  28 May 2018

Tory A. Eisenlohr-Moul ,
Katja M. Schmalenberger ,
Sarah A. Owens ,
Jessica R. Peters ,
Danyelle N. Dawson  and
Susan S. Girdler
Tory A. Eisenlohr-Moul*
Affiliation:
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA University of Illinois at Chicago, Chicago, IL, USA
Katja M. Schmalenberger
Affiliation:
Heidelberg University, Heidelberg, Germany
Sarah A. Owens
Affiliation:
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Jessica R. Peters
Affiliation:
Warren Alpert Medical School of Brown University, Providence, RI, USA
Danyelle N. Dawson
Affiliation:
University of Illinois at Urbana-Champaign, Champaign, IL, USA
Susan S. Girdler
Affiliation:
The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
*
Author for correspondence: Tory A. Eisenlohr-Moul, E-mail: [email protected]
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Abstract

Background

Individuals with a borderline personality disorder (BPD) suffer from a constellation of rapidly shifting emotional, interpersonal, and behavioral symptoms. The menstrual cycle may contribute to symptom instability among females with this disorder.

Methods

Fifteen healthy, unmedicated females with BPD and without dysmenorrhea reported daily symptoms across 35 days. Urine luteinizing hormone and salivary progesterone (P4) were used to confirm ovulation and cycle phase. Cyclical worsening of symptoms was evaluated using (1) phase contrasts in multilevel models and (2) the Carolina Premenstrual Assessment Scoring System (C-PASS), a protocol for evaluating clinically significant cycle effects on symptoms.

Results

Most symptoms demonstrated midluteal worsening, a perimenstrual peak, and resolution of symptoms in the follicular or ovulatory phase. Post-hoc correlations with person-centered progesterone revealed negative correlations with most symptoms. Depressive symptoms showed an unexpected delayed pattern in which baseline levels of symptoms were observed in the ovulatory and midluteal phases, and exacerbations were observed during both the perimenstrual and follicular phases. The majority of participants met C-PASS criteria for clinically significant (⩾30%) symptom exacerbation. All participants met the emotional instability criterion of BPD, and no participant met DSM-5 criteria for premenstrual dysphoric disorder (PMDD).

Conclusions

Females with BPD may be at elevated risk for perimenstrual worsening of emotional symptoms. Longitudinal studies with fine-grained hormonal measurement as well as hormonal experiments are needed to determine the pathophysiology of perimenstrual exacerbation in BPD.

Keywords

Borderline personality disordermenstrual cycleovarian steroid hormones
Type
Original Articles
Information
Psychological Medicine , Volume 48 , Issue 12 , September 2018 , pp. 2085 - 2095
Copyright
Copyright © Cambridge University Press 2018 

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