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Perceptual and physiological dysfunction in depression

Published online by Cambridge University Press:  09 July 2009

I. M. Blackburn ,
H. M. Roxborough ,
W. J. Muir ,
M. Glabus  and
D. H. R. Blackwood
I. M. Blackburn*
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital and the Departments of Psychiatry and Medical Physics, University of Edinburgh
H. M. Roxborough
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital and the Departments of Psychiatry and Medical Physics, University of Edinburgh
W. J. Muir
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital and the Departments of Psychiatry and Medical Physics, University of Edinburgh
M. Glabus
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital and the Departments of Psychiatry and Medical Physics, University of Edinburgh
D. H. R. Blackwood
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital and the Departments of Psychiatry and Medical Physics, University of Edinburgh
*
1Address for correspondence: Dr I. M. Blackburn, MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH 10 5HF.
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Synopsis

P300 responses to emotive words of different hedonic tones were assessed in depressed patients (unipolar major), patients recovered from the same type of depression and normal controls. Depressed patients showed a smaller amplitude of P300 in response to negatively toned words than to positive words; normal controls showed the opposite pattern and recovered patients showed a pattern of response which resembled that of depressed patients. The experimental trials comparing responses to negative and positive stimuli in relation to neutral words showed significant differences for negative as compared with neutral stimuli, but not for positive as compared with neutral stimuli. Latencies of P300 did not differentiate depressed patients from normal controls. The results are discussed within the context of the ‘expectancy’ theory of information processing.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 1 , February 1990 , pp. 95 - 103
Copyright
Copyright © Cambridge University Press 1990

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References

Beck, A. T. (1967). Depression: Clinical, Experimental and Theoretical Aspects. Harper & Row: New York.Google Scholar
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J. E. & Erbaugh, J. K. (1961). An inventory for measuring depression. Archives of General psychiatry 4, 561–571.Google Scholar
Beck, A. T., Rush, A. J.. Shaw, B. F. & Emery, G. (1979). Cognitive Therapy of Depression. Wiley: New York.Google Scholar
Beck, A. T., Epstein, N. & Harrison, R. (1983). Cognitions, attitudes and personality dimensions in depression. British Journal of Cognitive Psychotherapy 1, 1–11.Google Scholar
Blackburn, I. M. (1975). Mental and psychomotor speed in depression and mania. British Journal of Psychiatry 126, 329–335.Google Scholar
Blackburn, I. M. (1988). Psychological processes in depression. In Adult Abnormal Psychology (ed. Miller, E. & Cooper, P. J.), PP. 128–167. Churchill Livingstone: Edinburgh.Google Scholar
Blaney, P. H. (1986). Affect and memory: a review. Psychological Bulletin 99, 229–246.Google Scholar
Blackwood, D. H. R., Wahlley, L. J., Christie, J. E., Blackburn, I. M., St. Clair, D. M. & McInnes, A. (1987). Changes in auditory P3 event-related potential in schizophrenia and depression. British Journal of Psychiatry 150, 154–160.CrossRefGoogle ScholarPubMed
Clark, D. M. & Teasdale, J. D. (1985). Constraints on the effects of mood on memory. Journal of personality and Social Psychology 48, 1595–1608.Google Scholar
De Monbreun, B. G. & Craighead, W. E. (1977). Distortion of perception and recall of positive and neutral feedback in depression. Cognitive Therapy and Research 1, 311–330.CrossRefGoogle Scholar
Derry, P. A. & Kuiper, N. A. (1981). Schematic processing and self-reference in clinical depression. Journal of Abnormal Psychology 90, 286–297.CrossRefGoogle ScholarPubMed
Donchin, E. (1979). Even-related brain potentials: a tool in the study of human information processing. In Evoked Brain Potentials and Behaviour (ed. Begleiter, H.), pp. 13–88. Plenum Press: New York.Google Scholar
Greden, J. F. & Carroll, J. B. (1981). Psychomotor junction in affective disorders: an overview of new monitoring techniques. American Journal of Psychiatry 138, 1441–1448.Google Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology and of Neurosurgical Psychiatry 23, 59–61.Google Scholar
Hollon, S. & Kriss, M. (1984). Cognitive factors in clinical research and practice. Clinical Psychology Review 4, 35–76.CrossRefGoogle Scholar
Kuiper, N. A., Olinger, L. J. & Shaw, B. F. (1985). Self-schema processing of depressed and non-depressed content: The effects of vulnerability to depression. Social Cognition 3, 77–93.CrossRefGoogle Scholar
Lewinsohn, P. M., Mischel, W., Chaplain, W. & Barton, R. (1980). Social competence and depression: The role of illusory self-perceptions? Journal of Abnormal Psychology 89, 203–212.CrossRefGoogle ScholarPubMed
Lewinsohn, P. M., Steinmetz, J. L., Larson, D. W. & Franklin, J. (1981). Depression-related cognitions: antecedent or consequence? Journal of Abnormal Psychology 90, 213–219.CrossRefGoogle ScholarPubMed
Powell, M. & Hemsley, D. R. (1984). Depression: a breakdown of perceptual defence? British Journal of Psychiatry 145, 358–362.Google Scholar
Pritchard, W. S. (1981). Psychophysiology of P300. Psychological Bulletin 89, 506–540.Google Scholar
Rosler, F. (1983). Endogenous ER ‘Ps’ and Congnition: probes, prospects and pitfalls in matching pieces of the mind-body puzzle. In Tutorials in ERP Research; Endogenous Components (ed. Gaillard, A. W. K. and Ritter, W.). pp. 9–35. North-Holland Publishing: Amsterdam.Google Scholar
Snyder, M. (1981). Seek and ye shall find: testing hypotheses about people. In Social Congnition: the Ontario Symposium (ed. Higgins, E. T., Herman, C. P. and Zanna, M. P.), pp. 277–304. Erlbaum: Hillsdale, NJ.Google Scholar
Spitzer, R. L., Endicott, T. & Robins, E. (1978). Research Diagnostic Criteria for a Selected Group of Functional Disorders, 3rd ed. Biometric Research New York Psychiatric Institute: New York.Google Scholar
Squires, K. C., Wickens, C., Squires, N. K. & Donchin, E. (1976). The effect of stimulus sequence on the waveform of the cortical event-related potential. Science 193, 1142–1146.CrossRefGoogle ScholarPubMed
Teasdale, J. D. & Dent, J. (1987). Cognitive vulnerability to depression: an investigation of two hypotheses. British Journal of Clinical Psychology 26, 113–126.Google Scholar
Thorndike, E. & Lorge, I. (1944). The Teacher's Word Book of 30,000 Words. Teachers College, Columbia University: New York.Google Scholar
Weissman, A. N. & Beck, A. T. (1978). Development and validation of the Dysfunctional Attitude Scale.Paper presented at the annual meeting of the Association for Advancement of Behavior Therapy,Chicago.Google Scholar