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P300 waveform and dopamine transporter availability: a controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

Published online by Cambridge University Press:  15 November 2013

K. C. Chen ,
I. H. Lee ,
Y. K. Yang ,
S. Landau ,
W. H. Chang ,
P. S. Chen ,
R. B. Lu ,
A. S. David  and
E. Bramon
K. C. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
I. H. Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
Y. K. Yang*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
S. Landau
Affiliation:
Department of Biostatistics, Institute of Psychiatry, King's College London, UK
W. H. Chang
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan
P. S. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
R. B. Lu
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
A. S. David
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK
E. Bramon
Affiliation:
Department of Psychosis Studies, Institute of Psychiatry, King's College London, UK Department of Biological Psychiatry, Mental Health Sciences Unit and Institute of Cognitive Neuroscience, University College London, UK
*
* Address for correspondence: Y. K. Yang, M.D., Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, North Dist., Tainan 70403, Taiwan. (Email: [email protected])
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Abstract

Background

Reduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility.

Method

We explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study.

Results

No overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of −0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude.

Conclusions

Our findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.

Keywords

Dopamine transporterERPmedication-naive schizophreniameta-analysisP300 waveformsingle photon emission computerized tomography
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 10 , July 2014 , pp. 2151 - 2162
Copyright
Copyright © Cambridge University Press 2013 

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