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New findings on tardive dyskinesia in a community sample

Published online by Cambridge University Press:  09 July 2009

Peter O'Hara*
Affiliation:
Department of Psychiatry, University of Leicester, Leicester Royal Infirmary; Hôpital L-H Lafontaine, Département de Recherche, Montreal, Quebec, Canada; and MRC Social & Community Psychiatry Unit, Institute of Psychiatry, London
Traolach S. Brugha
Affiliation:
Department of Psychiatry, University of Leicester, Leicester Royal Infirmary; Hôpital L-H Lafontaine, Département de Recherche, Montreal, Quebec, Canada; and MRC Social & Community Psychiatry Unit, Institute of Psychiatry, London
Alain Lesage
Affiliation:
Department of Psychiatry, University of Leicester, Leicester Royal Infirmary; Hôpital L-H Lafontaine, Département de Recherche, Montreal, Quebec, Canada; and MRC Social & Community Psychiatry Unit, Institute of Psychiatry, London
John Wing
Affiliation:
Department of Psychiatry, University of Leicester, Leicester Royal Infirmary; Hôpital L-H Lafontaine, Département de Recherche, Montreal, Quebec, Canada; and MRC Social & Community Psychiatry Unit, Institute of Psychiatry, London
*
1Address for correspondence: Dr Peter O'Hara, Department of Psychiatry, Limerick Regional Hospital, Dooradoyle, Limerick, Republic of Ireland.

Synopsis

In a geographically defined area sample of 141 long-term psychiatric patients in day care in south London, the relationship between tardive dyskinesia (TD) and other aspects of illness, treatment, and social and psychological functioning were studied. The results are compared with previous findings. TD was significantly associated with parkinsonian symptoms and with the number of years in contact with the psychiatric services. There was a trend, in affective disorder only, towards an association with current neuroleptic dose. The patients with affective disorder also had higher rates of TD than patients with schizophrenia and paranoid psychosis. History of treatment with ECT correlated negatively with TD among those with schizophrenia, and positively among those with affective disorder. As in other studies, duration of neuroleptic treatment did not correlate with the presence or absence of TD. In contrast to some previous reports, age and cognitive status were not related to TD status. Possible reasons for this are discussed.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 1993

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References

Barnes, T. R. (1987). The present status of tardive dyskinesia and akathisia in the treatment of schizophrenia. Psychiatric Developments 4, 301319.Google Scholar
Branchey, M. & Branchey, L. (1984). Patterns of psychotropic drug use and tardive dyskinesia. Journal of Clinical Psychopharmacology 4, 4145.CrossRefGoogle ScholarPubMed
Brugha, T., Wing, J. K., Brewin, C. R., MacCarthy, B., Mangen, S., Lesage, A. & Mumford, J. (1988). The problems of people in long-term psychiatric day care: an introduction to the Camberwell High Contact Survey. Psychological Medicine 18, 443456.CrossRefGoogle Scholar
Chouinard, G., Annable, L., Ross-Chouinard, A. & Nestoros, J. N. (1979). Factors related to tardive dyskinesia. American Journal of Psychiatry 136, 7983.Google ScholarPubMed
Chouinard, G., Annable, L., Ross-Chouinard, A. & Mercier, P. (1988). A 5-year prospective longitudinal study of tardive dyskinesia: factors predicting appearance of new cases. Journal of Clinical Psychopharmacology 8 (4 Suppl), 21S26S.CrossRefGoogle ScholarPubMed
Chouinard, G., Annable, L., Ross-Chouinard, A. & Holobow, N. (1990). Factors affecting the course of tardive dyskinesia: a ten-year follow-up.Syllabus and Proceedings of the 143rd Annual Meeting of the American Psychiatric Association 67, 92.Google Scholar
Csernansky, J. G., Kaplan, J., Holman, C. A. & Hollisler, L. E. (1983). Serum neuroleptic activity, prolactin, and tardive dyskinesia in schizophrenic out-patients. Psychopharmacology (Berlin) 81, 115118.CrossRefGoogle Scholar
Davis, J. M. (1976). Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry 33, 858861.CrossRefGoogle ScholarPubMed
DeWolfe, A. S., Ryan, J. J. & Wolf, M. E. (1988). Cognitive sequelae of tardive dyskinesia. Journal of Nervous and Mental Disease 176, 270274.CrossRefGoogle ScholarPubMed
Fleischauer, J., Kocher, R., Hobi, V. & Gilsdorf, U. (1985). Prevalence of tardive dyskinesia in a clinic population. In Dyskinesia: Research and Treatment (ed. Casey, D. E., Chase, T. N., Christensen, A. V. and Gerlach, J.), pp. 162172. Springer-Verlag: Berlin.CrossRefGoogle Scholar
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975). Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189198.CrossRefGoogle Scholar
Gilleard, C. J. & Vaddadi, K. S. (1986). Mood, memory, and motor performance and the severity of tardive dyskinesia. Perceptual and Motor Skills 63, 10371038.CrossRefGoogle ScholarPubMed
Glazer, W. M. & Morgenstern, H. (1988). Predictors of occurrence, severity and course of tardive dyskinesia in an out-patient population. Journal of Clinical Psychopharmacology 8 (4 Suppl), 10S16S.CrossRefGoogle Scholar
Gureje, O. (1988). Topographic subtypes of tardive dyskinesia in schizophrenic patients aged less than 60 years: relationship to demographic, clinical, treatment and neuropsychological variables. Journal of Neurology, Neurosurgery and Psychiatry 51, 15251530.CrossRefGoogle ScholarPubMed
Kane, J. M., Woerner, M. & Lieberman, J. (1988). Tardive dyskinesia: prevalence, incidence, and risk factors. Journal of Clinical Psychopharmacology 8 (4 Suppl), 52S56S.CrossRefGoogle ScholarPubMed
Kane, J. M., Woerner, M., Borenstein, M., Wegner, J. & Lieberman, J. (1986). Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacology Bulletin 22, 254258.Google ScholarPubMed
Kidger, T., Barnes, T. R. E., Trauer, T. & Taylor, P. J. (1980). Subsyndromes of tardive dyskinesia. Psychological Medicine 10, 513520.CrossRefGoogle ScholarPubMed
Ko, G. N., Zhang, L. D., Yan, W. W., Zhang, M. D., Buchner, D., Xia, Z. Y., Wyatt, R. J. & Jeste, D. V. (1989). Tha Shanghai 800: prevalence of tardive dyskinesia in a Chinese psychiatric population. American Journal of Psychiatry 146, 387389.Google Scholar
Kok, L. P. & Christopher, Y. S. (1985). Tardive dyskinesia in schizophrenic out-patients. Annals of the Academy of Medicine of Singapore 14, 8790.Google Scholar
McCreadie, R. G., Barron, E. T. & Winslow, G. S. (1982). The Nithsdale Schizophrenia Survey. 2. Abnormal movements. British Journal of Psychiatry 140, 587590.CrossRefGoogle Scholar
Mukherjee, S., Rosen, A. M., Caracci, G. & Shukla, S. (1986). Persistent tardive dyskinesia in bipolar patients. Archives of General Psychiatry 43, 342346.CrossRefGoogle ScholarPubMed
National Institute of Mental Health. (1974). Abnormal Involuntary Movements Scale. Public Health Service: Bethesda, Maryland.Google Scholar
Owens, D. G. C. (1985). Involuntary disorders of movement in chronic schizophrenia – the role of the illness and its treatment. In Dyskinesia: Research and Treatment (ed. Casey, D. E., Chase, T. N., Christensen, A. V. and Gerlach, J.), pp. 7987. Springer-Verlag: Berlin.CrossRefGoogle Scholar
Ramsay, F. M. & Millard, P. H. (1986). Tardive dyskinesia in the elderly. Age and Aging 15, 145150.CrossRefGoogle ScholarPubMed
Rao, J. M., Cowie, V. A. & Mathew, B. (1987). Tardive dyskinesia in neuroleptic medicated mentally handicapped subjects. Acta Psychiatrica Scandinavica 76, 507513.CrossRefGoogle ScholarPubMed
Richardson, M. A., Pass, R., Bregman, Z. & Craig, T. J. (1985). Tardive dyskinesia and depressive symptoms in schizophrenics. Psychopharmacology Bulletin 21, 130135.Google ScholarPubMed
Schooler, N. R. & Kane, J. M. (1982). Research diagnoses for tardive dyskinesia. Archives of General Psychiatry 39, 486487.Google ScholarPubMed
Sorokin, J. E., Giordani, B., Mohs, R. C., Losonczy, M. F., Davidson, M., Siever, L. J., Ryan, T. A. & Davis, K. L. (1988). Memory impairment in schizophrenic patients with tardive dyskinesia. Biological Psychiatry 23, 129135.CrossRefGoogle ScholarPubMed
Struve, F. A. & Willner, A. E. (1983). Cognitive dysfunction and tardive dyskinesia. British Journal of Psychiatry 143, 597600.CrossRefGoogle ScholarPubMed
Tegeler, J., Strauss, W. H., Luethke, H. & Bertling, R. (1988). Cognitive functions in schizophrenic patients with tardive dyskinesia. Pharmacopsychiatry 21, 308309.CrossRefGoogle ScholarPubMed
Thomas, P. & McGuire, R. (1986). Orofacial dyskinesia, cognitive function and medication. British Journal of Psychiatry 149, 216220.CrossRefGoogle ScholarPubMed
Toenniessen, L. M., Casey, D. E. & McFarland, B. H. (1985). Tardive dyskinesia in the aged: duration of treatment relationships. Archives of General Psychiatry 42, 278284.CrossRefGoogle ScholarPubMed
Waddington, J. L. (1987). Tardive dyskinesia in schizophrenia and other disorders: associations with ageing, cognitive dysfunction and structural brain pathology in relation to neuroleptic exposure. Human Psychopharmacology 2, 1122.CrossRefGoogle Scholar
Waddington, J. L. (1989). Schizophrenia, affective psychoses, and other disorders treated with neuroleptic drugs: the enigma of tardive dyskinesia, its neurobiological determinants, and the conflict of paradigms. International Review of Neurobiology 31, 297353.CrossRefGoogle ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1986 a). An unusual cluster of tardive dyskinesia in schizophrenia: association with cognitive dysfunction and negative symptoms. American Journal of Psychiatry 143, 11621165.Google ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1986 b). Late onset involuntary movements in chronic schizophrenia – relationship of ‘tardive’ dyskinesia to intellectual impairment and negative symptoms. British Journal of Psychiatry 149, 616620.CrossRefGoogle ScholarPubMed
Waddington, J. L. & Youssef, H. A. (1986 c). Involuntary movements and cognitive dysfunction in late onset schizophrenic out-patients. Irish Medical Journal 79, 347350.Google Scholar
Waddington, J. L. & Youssef, H. A. (1988). Tardive dyskinesia in bipolar affective disorder: ageing, cognitive dysfunction, course of illness, and exposure to neuroleptics and lithium. American Journal of Psychiatry 145, 613616.Google ScholarPubMed
Wegner, J. T., Kane, J. M., Weinhold, P., Woerner, M., Kinon, B. & Lieberman, J. (1985 a). Cognitive impairment in tardive dyskinesia. Psychiatry Research 16, 331337.CrossRefGoogle ScholarPubMed
Wegner, J. T., Catalono, F., Gibralter, J. & Kane, J. M. (1985 b). Schizophrenics with tardive dyskinesia: neuropsychological deficit and family psychopathology. Archives of General Psychiatry 42, 860865.CrossRefGoogle ScholarPubMed
Wing, J. K., Babor, T., Brugha, T., Burke, J., Cooper, J. E., Giel, R., Jablenski, A., Regier, D. & Sartorius, N. (1990). SCAN: schedules for clinical assessment in neuropsychiatry. Archives of General Psychiatry 47, 589593.CrossRefGoogle ScholarPubMed
Wojcik, J. P., Gelenberg, A. J., La Brie, R. A. & Mieske, M. (1980). Prevalence of tardive dyskinesia in an out-patient population. Comprehensive Psychiatry 21, 370380.CrossRefGoogle Scholar
Wolf, M. E., DeWolfe, A. S. & Mosnaim, A. D. (1987). Risk factors for tardive dyskinesia according to primary psychiatric diagnosis. Hillside Journal of Clinical Psychiatry 9, 311.Google ScholarPubMed
Yassa, R., Ghadirian, A. M. & Schwartz, G. (1983). Prevalence of tardive dyskinesia in affective disorder patients. Journal of Clinical Psychiatry 44, 410412.Google ScholarPubMed