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Neuropsychological and P300 abnormalities in schizophrenics and their relatives

Published online by Cambridge University Press:  09 July 2009

H. Roxborough ,
W. J. Muir ,
D. H. R. Blackwood ,
M. T. Walker  and
I. M. Blackburn
H. Roxborough*
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh
W. J. Muir
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh
D. H. R. Blackwood
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh
M. T. Walker
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh
I. M. Blackburn
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh
*
1Address for correspondence: Dr H. Roxborough, University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF.
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Synopsis

Schizophrenic subjects (N = 30) performed less well than controls (N = 30) on neuropsychological tests sensitive to frontal and temporal lobe impairment and showed prolonged latency of the P300 event-related potential. Relatives of schizophrenic probands were also tested. Relatives with an abnormal P300 had a similar range of neuropsychological deficits as were found in the schizophrenic group and relatives with a normal P300 response performed as well as the normal control group. The results suggest that neurophysiological and neuropsychological testing of relatives may help to clarify the mode of inheritance of schizophrenia in some families.

Type
Original Articles
Information
Psychological Medicine , Volume 23 , Issue 2 , May 1993 , pp. 305 - 314
Copyright
Copyright © Cambridge University Press 1993

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