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The neural basis of consciousness

Published online by Cambridge University Press:  04 September 2019

Chris D. Frith Open the ORCID record for Chris D. Frith [Opens in a new window]
Chris D. Frith*
Affiliation:
Wellcome Centre for Human Neuroimaging at University College London, UK Institute of Philosophy, Institute of Advanced Study, University of London, UK
*
Author for correspondence: Chris D. Frith, E-mail: [email protected]
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Abstract

Consciousness has evolved and is a feature of all animals with sufficiently complex nervous systems. It is, therefore, primarily a problem for biology, rather than physics. In this review, I will consider three aspects of consciousness: level of consciousness, whether we are awake or in a coma; the contents of consciousness, what determines how a small amount of sensory information is associated with subjective experience, while the rest is not; and meta-consciousness, the ability to reflect upon our subjective experiences and, importantly, to share them with others. I will discuss and compare current theories of the neural and cognitive mechanisms involved in producing these three aspects of consciousness and conclude that the research in this area is flourishing and has already succeeded to delineate these mechanisms in surprising detail.

Keywords

Consciousnessevolutionmeta-consciousnessworking memory
Type
Invited Review
Information
Psychological Medicine , Volume 51 , Issue 4 , March 2021 , pp. 550 - 562
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Copyright
Copyright © Cambridge University Press 2019

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References

Aarts, H and Custers, R (2010) Habit, action, and consciousness. In Banks, WP (ed.), Encyclopedia of Consciousness, pp. 315–328. Oxford: Elsevier.Google Scholar
Altena, E, Rittman, T, Wolpe, N, Rowe, JB, Rae, CL, Moore, JW and Haggard, P (2013) The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome. Brain 137, 208–220.Google Scholar
American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders (DSM-5®). Arlington, VA: American Psychiatric Association.Google Scholar
Baars, BJ (1988) A Cognitive Theory of Consciousness. Cambridge, UK: Cambridge University Press.Google Scholar
Baars, BJ (2002) The conscious access hypothesis: origins and recent evidence. Trends in Cognitive Sciences 6, 47–52.CrossRefGoogle ScholarPubMed
Baddeley, A (1992) Consciousness and working memory. Consciousness and Cognition 1, 3–6.CrossRefGoogle Scholar
Bayne, T, Hohwy, J and Owen, AM (2016) Are there levels of consciousness? Trends in Cognitive Sciences 20, 405–413.CrossRefGoogle ScholarPubMed
Beck, DM, Rees, G, Frith, CD and Lavie, N (2001) Neural correlates of change detection and change blindness. Nature Neuroscience 4, 645–650.CrossRefGoogle ScholarPubMed
Beck, DM, Muggleton, N, Walsh, V and Lavie, N (2006) Right parietal cortex plays a critical role in change blindness. Cerebral Cortex 16, 712–717.CrossRefGoogle Scholar
Beilock, SL, Carr, TH, MacMahon, C and Starkes, JL (2002) When paying attention becomes counterproductive: impact of divided versus skill-focused attention on novice and experienced performance of sensorimotor skills. Journal of Experimental Psychology-Applied 8, 6–16.CrossRefGoogle ScholarPubMed
Bliksted, V, Samuelsen, E, Sandberg, K, Bibby, BM and Overgaard, MS (2017) Discriminating between first- and second-order cognition in first-episode paranoid schizophrenia. Cognitive Neuropsychiatry 22, 95–107.CrossRefGoogle ScholarPubMed
Boldt, A, Blundell, C and De Martino, B (2019) Confidence modulates exploration and exploitation in value-based learning. Neuroscience of Consciousness 2019(1). doi:10.1093/nc/niz004.CrossRefGoogle ScholarPubMed
Boly, M, Garrido, MI, Gosseries, O, Bruno, M-A, Boveroux, P, Schnakers, C, Massimini, M, Litvak, V, Laureys, S and Friston, K (2011) Preserved feedforward but impaired top-down processes in the vegetative state. Science 332, 858–862.CrossRefGoogle ScholarPubMed
Bor, D and Seth, A (2012) Consciousness and the prefrontal parietal network: insights from attention, working memory, and chunking. Frontiers in Psychology 3, 63.CrossRefGoogle ScholarPubMed
Botvinick, M, Ritter, S, Wang, JX, Kurth-Nelson, Z, Blundell, C and Hassabis, D (2019) Reinforcement learning, fast and slow. Trends in Cognitive Sciences 23, 408–422.CrossRefGoogle ScholarPubMed
Brebion, G, Ohlsen, RI, Bressan, RA and David, AS (2012) Source memory errors in schizophrenia, hallucinations and negative symptoms: a synthesis of research findings. Psychological Medicine 42, 2543–2554.CrossRefGoogle ScholarPubMed
Bronfman, ZZ, Ginsburg, S and Jablonka, E (2016) The transition to minimal consciousness through the evolution of associative learning. Frontiers in Psychology 7, 1954.CrossRefGoogle ScholarPubMed
Brown, R and McNeill, D (1966) The ‘tip of the tongue’ phenomenon. Journal of Verbal Learning and Verbal Behavior 5, 325–337.CrossRefGoogle Scholar
Bruner, E, Preuss, TM, Chen, X and Rilling, JK (2017) Evidence for expansion of the precuneus in human evolution. Brain structure & function 222, 1053–1060.CrossRefGoogle ScholarPubMed
Carhart-Harris, RL, Kaelen, M, Bolstridge, M, Williams, TM, Williams, LT, Underwood, R, Feilding, A and Nutt, DJ (2016) The paradoxical psychological effects of lysergic acid diethylamide (LSD). Psychological Medicine 46, 1379–1390.CrossRefGoogle Scholar
Carruthers, P (2000) The evolution of consciousness. In Carruthers, P and Chamberlain, A (eds), Evolution and the Human Mind: Modularity, Language and Meta-Cognition. Cambridge, UK: Cambridge University Press, pp. 254–275.CrossRefGoogle Scholar
Chalmers, DJ (1995) Facing up to the problem of consciousness. Journal of Consciousness Studies 2, 200–219.Google Scholar
Chambon, V and Haggard, P (2012) Sense of control depends on fluency of action selection, not motor performance. Cognition 125, 441–451.CrossRefGoogle Scholar
Charles, L, van Opstal, F, Marti, S and Dehaene, S (2013) Distinct brain mechanisms for conscious versus subliminal error detection. Neuroimage 73, 80–94.CrossRefGoogle ScholarPubMed
Cohen, BD (1976) Referent communication in schizophrenia: the perseverative-chaining model. Annals of the New York Academy of Sciences 270, 124–141.CrossRefGoogle ScholarPubMed
Collette, F and Van der Linden, M (2002) Brain imaging of the central executive component of working memory. Neuroscience & Biobehavioral Reviews 26, 105–125.CrossRefGoogle ScholarPubMed
Cowan, N (2001) The magical number 4 in short-term memory: a reconsideration of mental storage capacity. Behavioral and Brain Sciences 24, 87–114, discussion 114–85.CrossRefGoogle ScholarPubMed
Craig, A (2009) How do you feel – now? The anterior insula and human awareness. Nature Reviews Neuroscience 10, 59–70.CrossRefGoogle Scholar
Danion, JM, Rizzo, L and Bruant, A (1999) Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Archives of General Psychiatry 56, 639–644.CrossRefGoogle ScholarPubMed
David, AS (1990) Insight and psychosis. British Journal of Psychiatry 156, 798–808.CrossRefGoogle ScholarPubMed
Daw, ND, Kakade, S and Dayan, P (2002) Opponent interactions between serotonin and dopamine. Neural Networks 15, 603–616.CrossRefGoogle ScholarPubMed
de Bruxelles, S (2009) Sleepwalker Brian Thomas Admits Killing Wife While Fighting Intruders in Nightmare. London, UK: In The Times.Google Scholar
Dehaene, S, Lau, H and Kouider, S (2017) What is consciousness, and could machines have it? Science 358, 486–492.CrossRefGoogle Scholar
Dehaene, S, Naccache, L, Cohen, L, Bihan, DL, Mangin, JF, Poline, JB and Riviere, D (2001) Cerebral mechanisms of word masking and unconscious repetition priming. Nature Neuroscience 4, 752–758.CrossRefGoogle ScholarPubMed
Dehaene, S, Naccache, L, Le Clec, HG, Koechlin, E, Mueller, M, Dehaene-Lambertz, G, van de Moortele, PF and Le Bihan, D (1998) Imaging unconscious semantic priming. Nature 395, 597–600.CrossRefGoogle ScholarPubMed
Dehaene, S, Sergent, C and Changeux, J-P (2003) A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proceedings of the National Academy of Sciences 100, 8520.CrossRefGoogle ScholarPubMed
Doll, BB, Simon, DA and Daw, ND (2012) The ubiquity of model-based reinforcement learning. Current Opinion in Neurobiology 22, 1075–1081.CrossRefGoogle ScholarPubMed
Donahue, CJ, Glasser, MF, Preuss, TM, Rilling, JK and Van Essen, DC (2018) Quantitative assessment of prefrontal cortex in humans relative to nonhuman primates. Proceedings of the National Academy of Sciences 115, E5183–E5192.CrossRefGoogle ScholarPubMed
Driver, J and Vuilleumier, P (2001) Perceptual awareness and its loss in unilateral neglect and extinction. Cognition 79, 39–88.CrossRefGoogle ScholarPubMed
Dykstra, AR, Cariani, PA and Gutschalk, A (2017) A roadmap for the study of conscious audition and its neural basis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 372, 20160103.CrossRefGoogle Scholar
Eimer, M (1999) Facilitatory and inhibitory effects of masked prime stimuli on motor activation and behavioural performance. Acta Psychologica 101, 293–313.CrossRefGoogle ScholarPubMed
Engelien, A, Huber, W, Silbersweig, D, Stern, E, Frith, CD, Doring, W, Thron, A and Frackowiak, RS (2000) The neural correlates of ‘deaf-hearing’ in man: conscious sensory awareness enabled by attentional modulation. Brain 123(Pt 3), 532–545.CrossRefGoogle ScholarPubMed
Evans, JSBT and Stanovich, KE (2013) Dual-process theories of higher cognition: advancing the debate. Perspectives on Psychological Science 8, 223–241.CrossRefGoogle ScholarPubMed
Farrer, C and Franck, N (2007) Self-monitoring in schizophrenia. Current Psychiatry Reviews 3, 243–251.CrossRefGoogle Scholar
Fechner, GT (1860) Elemente der Psychophysik. Leipzig: Breitkopf und Härtel.Google Scholar
Feinberg, TE and Mallatt, J (2016) The nature of primary consciousness. A new synthesis. Consciousness and Cognition 43, 113–127.CrossRefGoogle ScholarPubMed
Fleming, SM and Daw, ND (2017) Self-evaluation of decision-making: a general Bayesian framework for metacognitive computation. Psychological Review 124, 91–114.CrossRefGoogle ScholarPubMed
Fleming, SM, Huijgen, J and Dolan, RJ (2012) Prefrontal contributions to metacognition in perceptual decision making. Journal of Neuroscience 32, 6117–6125.CrossRefGoogle ScholarPubMed
Fleming, SM and Lau, HC (2014) How to measure metacognition. Frontiers in Human Neuroscience 8, doi:10.3389/fnhum.2014.00443.CrossRefGoogle ScholarPubMed
Fleming, SM, Ryu, J, Golfinos, JG and Blackmon, KE (2014) Domain-specific impairment in metacognitive accuracy following anterior prefrontal lesions. Brain 137, 2811–2822.CrossRefGoogle ScholarPubMed
Fleming, SM, Weil, RS, Nagy, Z, Dolan, RJ and Rees, G (2010) Relating introspective accuracy to individual differences in brain structure. Science 329, 1541–1543.CrossRefGoogle ScholarPubMed
Florindo, I, Bisulli, F, Pittau, F, Naldi, I, Striano, P, Striano, S, Michelucci, R, Testoni, S, Baruzzi, A and Tinuper, P (2006) Lateralizing value of the auditory aura in partial seizures. Epilepsia 47( Suppl. 5), 68–72.CrossRefGoogle Scholar
Fourneret, P and Jeannerod, M (1998) Limited conscious monitoring of motor performance in normal subjects. Neuropsychologia 36, 1133–1140.CrossRefGoogle ScholarPubMed
Fried, I, Katz, A, McCarthy, G, Sass, KJ, Williamson, P, Spencer, SS and Spencer, DD (1991) Functional organization of human supplementary motor cortex studied by electrical stimulation. The Journal of Neuroscience 11, 3656.CrossRefGoogle ScholarPubMed
Fried, I, Mukamel, R and Kreiman, G (2011) Internally generated preactivation of single neurons in human medial frontal cortex predicts volition. Neuron 69, 548–562.CrossRefGoogle ScholarPubMed
Friedman-Hill, SR, Robertson, LC and Treisman, A (1995) Parietal contributions to visual feature binding: evidence from a patient with bilateral lesions. Science 269, 853–855.CrossRefGoogle ScholarPubMed
Frith, CD (1979) Consciousness, information processing and schizophrenia. British Journal of Psychiatry 134, 225–235.CrossRefGoogle Scholar
Frith, CD (2014) Action, agency and responsibility. Neuropsychologia 55, 137–142.CrossRefGoogle ScholarPubMed
Frith, CD and Metzinger, T (2016) What's the use of consciousness? In Engel, AK, Friston, K and Kragic, D (eds), Where's the Action? The Pragmatic Turn in Cognitive Science. Cambridge, MA: MIT Press, pp. 193–214.CrossRefGoogle Scholar
Fusaroli, R, Bahrami, B, Olsen, K, Roepstorff, A, Rees, G, Frith, C and Tylen, K (2012) Coming to terms: quantifying the benefits of linguistic coordination. Psychological Science 23, 931–939.CrossRefGoogle ScholarPubMed
Giles, N, Lau, H and Odegaard, B (2016) What type of awareness does binocular rivalry assess? Trends in Cognitive Sciences 20, 719–720.CrossRefGoogle ScholarPubMed
Gläscher, J, Daw, N, Dayan, P and O'Doherty, JP (2010) States versus rewards: dissociable neural prediction error signals underlying model-based and model-free reinforcement learning. Neuron 66, 585–595.CrossRefGoogle ScholarPubMed
Gobet, F, Lane, PCR, Croker, S, Cheng, PCH, Jones, G, Oliver, I and Pine, JM (2001) Chunking mechanisms in human learning. Trends in Cognitive Sciences 5, 236–243.CrossRefGoogle ScholarPubMed
Goldhill, O (2018) The idea that everything from spoons to stones is conscious is gaining academic credibility. In Quartz. Available at https://qz.com/1184574/the-idea-that-everything-from-spoons-to-stones-are-conscious-is-gaining-academic-credibility/. (Accessed 22 August 2019).Google Scholar
Goodale, MA and Milner, AD (2004) Sight Unseen. Oxford: Oxford University Press.Google Scholar
Griffiths, TD and Warren, JD (2002) The planum temporale as a computational hub. Trends in Neurosciences 25, 348–353.CrossRefGoogle ScholarPubMed
Guggenmos, M and Sterzer, P (2017) A confidence-based reinforcement learning model for perceptual learning. Available at http://biorxiv.org/content/early/2017/05/11/136903.abstract. (Accessed 22 August 2019).CrossRefGoogle Scholar
Hahn, A, Wadsak, W, Windischberger, C, Baldinger, P, Höflich, AS, Losak, J, Nics, L, Philippe, C, Kranz, GS, Kraus, C, Mitterhauser, M, Karanikas, G, Kasper, S and Lanzenberger, R (2012) Differential modulation of the default mode network via serotonin-1A receptors. Proceedings of the National Academy of Sciences 109, 2619.CrossRefGoogle ScholarPubMed
Harlow, HF (1949) The formation of learning sets. Psychological Review 56, 51–65.CrossRefGoogle ScholarPubMed
Heilbronner, SR and Platt, ML (2013) Causal evidence of performance monitoring by neurons in posterior cingulate cortex during learning. Neuron 80, 1384–1391.CrossRefGoogle ScholarPubMed
Hoel, EP (2017) When the map is better than the territory. Entropy 19, doi:10.3390/e19050188.CrossRefGoogle Scholar
Hudetz, AG and Mashour, GA (2016) Disconnecting consciousness: is there a common anesthetic end point? Anesthesia & Analgesia 123, 1228–1240.CrossRefGoogle Scholar
Huys, QJ, Lally, N, Faulkner, P, Eshel, N, Seifritz, E, Gershman, SJ, Dayan, P and Roiser, JP (2015) Interplay of approximate planning strategies. Proceedings of the National Academy of Sciences of the USA 112, 3098–3103.CrossRefGoogle ScholarPubMed
Huys, QJM, Cruickshank, A and Seriès, P (2013) Reward-Based learning, model-based and model-free. In Jaeger, D and Jung, R (eds), Encyclopedia of Computational Neuroscience, pp. 1–10. New York, NY: Springer New York.Google Scholar
Jacob, P and Jeannerod, M (2003) Ways of Seeing: The Scope and Limits of Visual Cognition. Oxford, UK: Oxford University Press.CrossRefGoogle Scholar
Jacob, SN and Nienborg, H (2018) Monoaminergic neuromodulation of sensory processing. Frontiers in Neural Circuits 12, 51.CrossRefGoogle ScholarPubMed
Jeannerod, M (2001) Neural simulation of action: a unifying mechanism for motor cognition. Neuroimage 14, S103–S109.CrossRefGoogle ScholarPubMed
Jensen, MS, Yao, R, Street, WN and Simons, DJ (2011) Change blindness and inattentional blindness. Wiley interdisciplinary Reviews. Cognitive Science 2, 529–546.CrossRefGoogle ScholarPubMed
Kim, CY and Blake, R (2005) Psychophysical magic: rendering the visible ‘invisible’. Trends in Cognitive Sciences 9, 381–388.CrossRefGoogle Scholar
Kouider, S, de Gardelle, V, Sackur, J and Dupoux, E (2010) How rich is consciousness? The partial awareness hypothesis. Trends in Cognitive Sciences 14, 301–307.CrossRefGoogle Scholar
Lamme, VAF and Roelfsema, PR (2000) The distinct modes of vision offered by feedforward and recurrent processing. Trends in Neurosciences 23, 571–579.CrossRefGoogle ScholarPubMed
Lau, H and Rosenthal, D (2011) Empirical support for higher-order theories of conscious awareness. Trends in Cognitive Sciences 15, 365–373.CrossRefGoogle ScholarPubMed
Lau, HC, Rogers, RD, Haggard, P and Passingham, RE (2004) Attention to intention. Science 303, 1208–1210.CrossRefGoogle ScholarPubMed
Laureys, S, Faymonville, ME, Luxen, A, Lamy, M, Franck, G and Maquet, P (2000) Restoration of thalamocortical connectivity after recovery from persistent vegetative state. Lancet 355, 1790–1791.CrossRefGoogle ScholarPubMed
Lee, D, McGreevy, BP and Barraclough, DJ (2005) Learning and decision making in monkeys during a rock-paper-scissors game. Brain Research. Cognitive Brain Research 25, 416–430.CrossRefGoogle ScholarPubMed
Lee, HW, Hong, SB, Seo, DW, Tae, WS and Hong, SC (2000) Mapping of functional organization in human visual cortex: electrical cortical stimulation. Neurology 54, 849–854.CrossRefGoogle ScholarPubMed
Leopold, DA and Logothetis, NK (1996) Activity changes in early visual cortex reflect monkeys’ percepts during binocular rivalry. Nature 379, 549–553.CrossRefGoogle ScholarPubMed
Lewis, CR, Preller, KH, Kraehenmann, R, Michels, L, Staempfli, P and Vollenweider, FX (2017) Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow. NeuroImage 159, 70–78.CrossRefGoogle ScholarPubMed
Logan, GD and Crump, MJ (2010) Cognitive illusions of authorship reveal hierarchical error detection in skilled typists. Science 330, 683–686.CrossRefGoogle ScholarPubMed
Low, P, Panksepp, J, Reiss, D, Edelman, D, Van Swinderen, B and Koch, C (2012) The Cambridge declaration on consciousness. Available at http://fcmconference.org/img/CambridgeDeclarationOnConsciousness.pdf. (Accessed 22 August 2019).Google Scholar
Lysaker, PH, Dimaggio, G, Carcione, A, Procacci, M, Buck, KD, Davis, LW and Nicolo, G (2010) Metacognition and schizophrenia: the capacity for self-reflectivity as a predictor for prospective assessments of work performance over six months. Schizophrenia Research 122, 124–130.CrossRefGoogle ScholarPubMed
Marr, D (1982) Vision: A Computational Investigation Into the Human Representation and Processing of Visual Information. New York, NY 2: Henry holt and co. Inc.Google Scholar
McCurdy, LY, Maniscalco, B, Metcalfe, J, Liu, KY, de Lange, FP and Lau, H (2013) Anatomical coupling between distinct metacognitive systems for memory and visual perception. The Journal of Neuroscience 33, 1897–1906.CrossRefGoogle ScholarPubMed
McGinn, C (2012) All machine and no ghost? New Statesman (London, England. Available at https://www.newstatesman.com/ideas/2012/02/consciousness-mind-brain. (Accessed 22 August 2019).Google Scholar
Mégevand, P, Groppe, DM, Goldfinger, MS, Hwang, ST, Kingsley, PB, Davidesco, I and Mehta, AD (2014) Seeing scenes: topographic visual hallucinations evoked by direct electrical stimulation of the parahippocampal place area. The Journal of Neuroscience 34, 5399–5405.CrossRefGoogle ScholarPubMed
Metcalfe, J (2008) Evolution of metacognition. In Dunlosky, J. and Bjork, R. (eds), Handbook of Metamemory and Memory, pp. 29–46. Psychology Press: New York.Google Scholar
Metcalfe, JE and Shimamura, AP (1994) Metacognition: Knowing About Knowing. The MIT Press: Cambridge, MA.CrossRefGoogle Scholar
Michel, M, Beck, D, Block, N, Blumenfeld, H, Brown, R, Carmel, D, Carrasco, M, Chirimuuta, M, Chun, M, Cleeremans, A, Dehaene, S, Fleming, SM, Frith, C, Haggard, P, He, BJ, Heyes, C, Goodale, MA, Irvine, L, Kawato, M, Kentridge, R, King, J-R, Knight, RT, Kouider, S, Lamme, V, Lamy, D, Lau, H, Laureys, S, LeDoux, J, Lin, Y-T, Liu, K, Macknik, SL, Martinez-Conde, S, Mashour, GA, Melloni, L, Miracchi, L, Mylopoulos, M, Naccache, L, Owen, AM, Passingham, RE, Pessoa, L, Peters, MAK, Rahnev, D, Ro, T, Rosenthal, D, Sasaki, Y, Sergent, C, Solovey, G, Schiff, ND, Seth, A, Tallon-Baudry, C, Tamietto, M, Tong, F, van Gaal, S, Vlassova, A, Watanabe, T, Weisberg, J, Yan, K and Yoshida, M (2019) Opportunities and challenges for a maturing science of consciousness. Nature Human Behaviour 3, 104–107.CrossRefGoogle Scholar
Miele, DB, Wager, TD, Mitchell, JP and Metcalfe, J (2011) Dissociating neural correlates of action monitoring and metacognition of agency. Journal of Cognitive Neuroscience 23, 3620–3636.CrossRefGoogle ScholarPubMed
Miller, GA (1956) The magical number seven, plus or minus two. The Psychological Review 63, 81–97.CrossRefGoogle ScholarPubMed
Millière, R, Carhart-Harris, RL, Roseman, L, Trautwein, F-M and Berkovich-Ohana, A (2018) Psychedelics, meditation, and self-consciousness. Frontiers in Psychology 9, doi:10.3389/fpsyg.2018.01475.CrossRefGoogle ScholarPubMed
Moutoussis, K and Zeki, S (2002) The relationship between cortical activation and perception investigated with invisible stimuli. Proceedings of the National Academy of Sciences of the USA 99, 9527–9532.CrossRefGoogle ScholarPubMed
Nachev, P and Husain, M (2007) Comment on ‘detecting awareness in the vegetative state’. Science (New York, NY) 315, 1221–1221.CrossRefGoogle Scholar
Nelson, TO and Narens, L (1990). Metamemory: a theoretical framework and new findings. In Bower, G (ed.), The Psychology of Learning and Motivation, pp. 125–140. Academic Press: New York.Google Scholar
Noe, A, Pessoa, L and Thompson, E (2000) Beyond the grand illusion: what change blindness really teaches us about vision. Visual Cognition 7, 93–106.CrossRefGoogle Scholar
Northoff, G, Heinzel, A, de Greck, M, Bermpohl, F, Dobrowolny, H and Panksepp, J (2006) Self-referential processing in our brain – a meta-analysis of imaging studies on the self. NeuroImage 31, 440–457.CrossRefGoogle Scholar
Odegaard, B, Knight, RT and Lau, H (2017) Should a few null findings falsify prefrontal theories of conscious perception? The Journal of Neuroscience 37, 9593.CrossRefGoogle ScholarPubMed
Overgaard, M and Fazekas, P (2016) Can no-report paradigms extract true correlates of consciousness? Trends in Cognitive Sciences 20, 241–242.CrossRefGoogle Scholar
Owen, AM, Coleman, MR, Boly, M, Davis, MH, Laureys, S and Pickard, JD (2006) Detecting awareness in the vegetative state. Science 313, 1402.CrossRefGoogle ScholarPubMed
Penfield, W and Perot, P (1963) The brain's record of auditory and visual experience. A final summary and discussion. Brain 86, 595–696.CrossRefGoogle ScholarPubMed
Pessiglione, M, Schmidt, L, Draganski, B, Kalisch, R, Lau, H, Dolan, RJ and Frith, CD (2007) How the brain translates money into force: a neuroimaging study of subliminal motivation. Science 316, 904.CrossRefGoogle ScholarPubMed
Proust, J (2010) Metacognition. Philosophy Compass 5, 989–998.CrossRefGoogle Scholar
Purcell, BA and Kiani, R (2016) Hierarchical decision processes that operate over distinct timescales underlie choice and changes in strategy. Proceedings of the National Academy of Sciences 113, E4531–E4540.CrossRefGoogle ScholarPubMed
Quentin, R, King, J-R, Sallard, E, Fishman, N, Thompson, R, Buch, ER and Cohen, LG (2019) Differential brain mechanisms of selection and maintenance of information during working memory. The Journal of Neuroscience 39, 3728.CrossRefGoogle ScholarPubMed
Rabbitt, PM (1966) Errors and error correction in choice-response tasks. Journal of Experimental Psychology 71, 264–272.CrossRefGoogle ScholarPubMed
Ramnani, N and Owen, AM (2004) Anterior prefrontal cortex: insights into function from anatomy and neuroimaging. Nature Reviews Neuroscience 5, 184–194.CrossRefGoogle ScholarPubMed
Ramsøy, TZ and Overgaard, M (2004) Introspection and subliminal perception. Phenomenology and the Cognitive Sciences 3, 1–23.CrossRefGoogle Scholar
Read, JCA (2015) The place of human psychophysics in modern neuroscience. Neuroscience 296, 116–129.CrossRefGoogle ScholarPubMed
Rees, G, Kreiman, G and Koch, C (2002a) Neural correlates of consciousness in humans. Nature Reviews Neuroscience 3, 261–270.CrossRefGoogle Scholar
Rees, G, Wojciulik, E, Clarke, K, Husain, M, Frith, C and Driver, J (2002b) Neural correlates of conscious and unconscious vision in parietal extinction. Neurocase 8, 387–393.CrossRefGoogle Scholar
Rohe, T and Noppeney, U (2015) Cortical hierarchies perform Bayesian causal inference in multisensory perception. PLoS Biology 13, e1002073.CrossRefGoogle ScholarPubMed
Rolnick, J and Parvizi, J (2011) Automatisms: bridging clinical neurology with criminal law. Epilepsy & behavior 20, 423–427.CrossRefGoogle ScholarPubMed
Rouault, M, Seow, T, Gillan, CM and Fleming, SM (2018) Psychiatric symptom dimensions are associated with dissociable shifts in metacognition but not task performance. Biological Psychiatry 84, 443–451.CrossRefGoogle Scholar
Rounis, E, Maniscalco, B, Rothwell, JC, Passingham, RE and Lau, H (2010) Theta-burst transcranial magnetic stimulation to the prefrontal cortex impairs metacognitive visual awareness. Cognitive Neuroscience 1, 165–175.CrossRefGoogle ScholarPubMed
Salin, PA and Bullier, J (1995) Corticocortical connections in the visual system: structure and function. Physiological reviews 75, 107–154.CrossRefGoogle ScholarPubMed
Schiff, ND, Giacino, JT, Kalmar, K, Victor, JD, Baker, K, Gerber, M, Fritz, B, Eisenberg, B, O'Connor, J, Kobylarz, EJ, Farris, S, Machado, A, McCagg, C, Plum, F, Fins, JJ and Rezai, AR (2007) Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 448, 600.CrossRefGoogle ScholarPubMed
Schooler, JW (2002) Re-representing consciousness: dissociations between experience and meta-consciousness. Trends in Cognitive Sciences 6, 339–344.CrossRefGoogle ScholarPubMed
Schwartz, S, Assal, F, Valenza, N, Seghier, ML and Vuilleumier, P (2004) Illusory persistence of touch after right parietal damage: neural correlates of tactile awareness. Brain 128, 277–290.CrossRefGoogle ScholarPubMed
Semendeferi, K, Armstrong, E, Schleicher, A, Zilles, K and Van Hoesen, GW (2001) Prefrontal cortex in humans and apes: a comparative study of area 10. American Journal of Physical Anthropology 114, 224–241.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Shallice, T (1982) Specific impairments of planning. Philosophical Transactions of the Royal Society of London B Biological Sciences 298, 199–209.Google ScholarPubMed
Shea, N and Frith, CD (2016) Dual-process theories and consciousness: the case for ‘type zero’ cognition. Neuroscience of Consciousness 1, niw005.CrossRefGoogle Scholar
Shea, NJ, Boldt, A, Bang, D, Yeung, N, Heyes, C and Frith, CD (2014) Supra-personal cognitive control and metacognition. Trends in Cognitive Sciences 18, 186–193.CrossRefGoogle ScholarPubMed
Shea, NJ and Frith, CD (2019) The global workspace needs metacognition. Trends in Cognitive Sciences 23, P560–571.CrossRefGoogle ScholarPubMed
Shepherd, J (2012) Free will and consciousness: experimental studies. Consciousness and Cognition 21, 915–927.CrossRefGoogle ScholarPubMed
Shimamura, AP (2000) Toward a cognitive neuroscience of metacognition. Consciousness and Cognition 9, 313–323, discussion 324–6.CrossRefGoogle Scholar
Sirigu, A, Daprati, E, Ciancia, S, Giraux, P, Nighoghossian, N, Posada, A and Haggard, P (2004) Altered awareness of voluntary action after damage to the parietal cortex. Nature Neuroscience 7, 80–84.CrossRefGoogle ScholarPubMed
Slachevsky, A, Pillon, B, Fourneret, P, Pradat-Diehl, P, Jeannerod, M and Dubois, B (2001) Preserved adjustment but impaired awareness in a sensory-motor conflict following prefrontal lesions. Journal of Cognitive Neuroscience 13, 332–340.CrossRefGoogle Scholar
Smith, JD, Shields, WE and Washburn, DA (2003) The comparative psychology of uncertainty monitoring and metacognition. Behavioral and Brain Sciences 26, 317–339, discussion 340–73.CrossRefGoogle ScholarPubMed
Soddu, A, Vanhaudenhuyse, A, Schnakers, C, Bruno, M-A, Maquet, P, Noirhomme, Q, Tshibanda, LJF, Ledoux, D, Boveroux, P, Boly, M, Laureys, S, Brichant, J-F, Perlbarg, V, Moonen, G and Greicius, MD (2009) Default network connectivity reflects the level of consciousness in non-communicative brain-damaged patients. Brain 133, 161–171.Google Scholar
Sperduti, M, Delaveau, P, Fossati, P and Nadel, J (2011) Different brain structures related to self- and external-agency attribution: a brief review and meta-analysis. Brain Structure and Function 216, 151–157.CrossRefGoogle ScholarPubMed
Stender, J, Kupers, R, Rodell, A, Thibaut, A, Chatelle, C, Bruno, MA, Gejl, M, Bernard, C, Hustinx, R, Laureys, S and Gjedde, A (2015) Quantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients. Journal of Cerebral Blood Flow & Metabolism 35, 58–65.CrossRefGoogle ScholarPubMed
Stender, J, Mortensen, KN, Thibaut, A, Darkner, S, Laureys, S, Gjedde, A and Kupers, R (2016) The minimal energetic requirement of sustained awareness after brain injury. Current Biology 26, 1494–1499.CrossRefGoogle ScholarPubMed
Studerus, E, Kometer, M, Hasler, F and Vollenweider, FX (2010) Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies. Journal of Psychopharmacology 25, 1434–1452.CrossRefGoogle ScholarPubMed
Teuchies, M, Desender, K, de Baene, W, Demanet, J and Brass, M (2019) Metacognitive awareness of difficulty in action selection: the role of the cingulo-opercular network. Availabe at http://biorxiv.org/content/early/2019/05/17/641340.abstract. (Accessed 22 August 2019).CrossRefGoogle Scholar
Tolman, EC, Ritchie, BF and Kalish, D (1946) Studies in spatial learning. I. Orientation and the short-cut. Journal of Experimental Psychology 36, 13–24.CrossRefGoogle ScholarPubMed
Tong, F, Nakayama, K, Vaughan, JT and Kanwisher, N (1998) Binocular rivalry and visual awareness in human extrastriate cortex. Neuron 21, 753–759.CrossRefGoogle ScholarPubMed
Tononi, G (2008) Consciousness as integrated information: a provisional manifesto. Biological Bulletin 215, 216–242.CrossRefGoogle ScholarPubMed
Trübutschek, D, Marti, S, Ueberschär, H and Dehaene, S (2019) Probing the limits of activity-silent non-conscious working memory. Proceedings of the National Academy of Sciences 116, 14358–14367.CrossRefGoogle ScholarPubMed
Vaccaro, AG and Fleming, SM (2018) Thinking about thinking: a coordinate-based meta-analysis of neuroimaging studies of metacognitive judgements. Brain and Neuroscience Advances 2, 2398212818810591–2398212818810591.CrossRefGoogle ScholarPubMed
Valenza, N, Seghier, ML, Schwartz, S, Lazeyras, F and Vuilleumier, P (2004) Tactile awareness and limb position in neglect: functional magnetic resonance imaging. Annals of Neurology 55, 139–143.CrossRefGoogle ScholarPubMed
Vuilleumier, P, Armony, JL, Clarke, K, Husain, M, Driver, J and Dolan, RJ (2002) Neural response to emotional faces with and without awareness: event-related fMRI in a parietal patient with visual extinction and spatial neglect. Neuropsychologia 40, 2156–2166.CrossRefGoogle Scholar
Wager, TD and Smith, EE (2003) Neuroimaging studies of working memory. Cognitive, Affective, & Behavioral Neuroscience 3, 255–274.CrossRefGoogle ScholarPubMed
Whalen, PJ, Rauch, SL, Etcoff, NL, McInerney, SC, Lee, MB and Jenike, MA (1998) Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. Journal of Neuroscience 18, 411–418.CrossRefGoogle ScholarPubMed
Wilson, BA, Baddeley, AD and Kapur, N (1995) Dense amnesia in a professional musician following herpes simplex virus encephalitis. Journal of Clinical and Experimental Neuropsychology 17, 668–681.CrossRefGoogle Scholar
Wokke, ME, Achoui, D and Cleeremans, A (2019) Action information contributes to metacognitive decision-making. Available at http://biorxiv.org/content/early/2019/06/02/657957.abstract. (Accessed 22 August 2019).CrossRefGoogle Scholar
Yanakieva, S, Polychroni, N, Family, N, Williams, LTJ, Luke, DP and Terhune, DB (2018) The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial. Psychopharmacology 236, 1159–1170.CrossRefGoogle ScholarPubMed
Zamberlan, F, Sanz, C, Martínez Vivot, R, Pallavicini, C, Erowid, F, Erowid, E and Tagliazucchi, E (2018) The varieties of the psychedelic experience: a preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines. Frontiers in Integrative Neuroscience 12, doi:10.3389/fnint.2018.00054.CrossRefGoogle ScholarPubMed
Zaretskaya, N, Thielscher, A, Logothetis, NK and Bartels, A (2010) Disrupting parietal function prolongs dominance durations in binocular rivalry. Current Biology 20, 2106–2111.CrossRefGoogle ScholarPubMed
Zeki, S (1990) A century of cerebral achromatopsia. Brain 113(Pt 6), 1721–1777.CrossRefGoogle ScholarPubMed
Zeki, S (1991) Cerebral akinetopsia (visual motion blindness). A review. Brain 114(Pt 2), 811–824.CrossRefGoogle ScholarPubMed