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Metacognitive group training for schizophrenia spectrum patients with delusions: a randomized controlled trial

Published online by Cambridge University Press:  26 March 2014

B. van Oosterhout*
Affiliation:
GGzE, De Woenselse Poort, Eindhoven, The Netherlands
L. Krabbendam
Affiliation:
Department of Educational Neuroscience, VU University Amsterdam, The Netherlands
K. de Boer
Affiliation:
Retired clinical psychologist, Heiloo, The Netherlands
J. Ferwerda
Affiliation:
GGZ Noord-Holland-Noord, Heiloo, The Netherlands
M. van der Helm
Affiliation:
Centre for Early Psychosis, Parnassia Psychiatric Institute, The Hague, The Netherlands
A. D. Stant
Affiliation:
Department of Epidemiology, University Medical Centre Groningen, The Netherlands
M. van der Gaag
Affiliation:
Department of Psychosis Research, Parnassia Psychiatric Institute, The Hague, The Netherlands VU University and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
*
* Address for correspondence: B. van Oosterhout, M.Sc., GGzE, PO Box 909, 5600 AX, Eindhoven, The Netherlands. (Email: [email protected])

Abstract

Background

Metacognitive training (MCT) for patients with psychosis is a psychological group intervention that aims to educate patients about common cognitive biases underlying delusion formation and maintenance, and to highlight their negative consequences in daily functioning.

Method

In this randomized controlled trial, 154 schizophrenia spectrum patients with delusions were randomly assigned to either MCT + treatment as usual (TAU) or TAU alone. Both groups were assessed at baseline, and again after 8 and 24 weeks. The trial was completed fully by 111 patients. Efficacy was measured with the Psychotic Symptom Rating Scales (PSYRATS) Delusions Rating Scale (DRS), and with specific secondary measures referring to persecutory ideas and ideas of social reference (the Green Paranoid Thoughts Scale, GPTS), cognitive insight (the Beck Cognitive Insight Scale, BCIS), subjective experiences of cognitive biases (the Davos Assessment of Cognitive Biases Scale, DACOBS) and metacognitive beliefs (the 30-item Metacognitions Questionnaire, MCQ-30). Economic analysis focused on the balance between societal costs and health outcomes (quality-adjusted life years, QALYs).

Results

Both conditions showed a decrease of delusions. MCT was not more efficacious in terms of reducing delusions, nor did it change subjective paranoid thinking and ideas of social reference, cognitive insight or subjective experience of cognitive biases and metacognitive beliefs. The results of the economic analysis were not in favour of MCT + TAU.

Conclusions

In the present study, MCT did not affect delusion scores and self-reported cognitive insight, or subjective experience of cognitive biases and metacognitive beliefs. MCT was not cost-effective.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2014 

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References

Aghotor, J, Pfueller, U, Moritz, S, Weisbrod, M, Roesch-Ely, D (2010). Metacognitive training for patients with schizophrenia (MCT): feasibility and preliminary evidence for its efficacy. Journal of Behavior Therapy and Experimental Psychiatry 41, 207211.CrossRefGoogle ScholarPubMed
Aleman, A, Hijman, R, de Haan, EH, Kahn, RS (1999). Memory impairment in schizophrenia: a meta-analysis. American Journal of Psychiatry 156, 13581366.CrossRefGoogle ScholarPubMed
APA (2000). Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. DSM-IV-TR. American Psychiatric Association: Washington, DC.Google Scholar
Bechdolf, A, Knost, B, Kuntermann, C, Schiller, S, Klosterkötter, J, Hambrecht, M, Pukrop, R (2004). A randomized comparison of group cognitive-behavioural therapy and group psychoeducation in patients with schizophrenia. Acta Psychiatrica Scandinavica 110, 2128.Google Scholar
Beck, AT, Baruch, E, Balter, JM, Steer, RA, Warman, DM (2004). A new instrument for measuring insight: the Beck Cognitive Insight Scale. Schizophrenia Research 68, 319329.Google Scholar
Beck, AT, Weishaar, M (1989). Cognitive therapy. In Comprehensive Handbook of Cognitive Therapy (ed. Freeman, A., Simon, K. M., Bentler, L. E. and Arkowitz, H.), pp. 2829. Plenum Press: New York.Google Scholar
Bentall, RP, Kinderman, P, Kaney, S (1994). The self, attributional processes and abnormal beliefs: towards a model of persecutory delusions. Behaviour Research and Therapy 32, 331341.Google Scholar
Brüne, M (2005). ‘Theory of mind’ in schizophrenia: a review of the literature. Schizophrenia Bulletin 31, 2142.Google Scholar
Cunningham Owens, DG, Carroll, A, Fattah, S, Clyde, Z, Coffey, I, Johnstone, EC (2001). A randomized, controlled trial of a brief interventional package for schizophrenic out-patients. Acta Psychiatrica Scandinavica 103, 362369.Google Scholar
Drake, R, Haddock, G, Tarrier, N, Bentall, R, Lewis, S (2007). The Psychotic Symptom Rating Scales (PSYRATS): their usefulness and properties in first episode psychosis. Schizophrenia Research 89, 119122.Google Scholar
Efron, B, Tibshirani, RJ (1993). An Introduction to the Bootstrap. Chapman & Hall: New York.CrossRefGoogle Scholar
EuroQol Group (1990). EuroQol – a new facility for the measurement of health-related quality of life. Health Policy 16, 199208.Google Scholar
Favrod, J, Maire, A, Bardy, S, Pernier, S, Bonsack, C (2011). Improving insight into delusions: a pilot study of metacognitive training for patients with schizophrenia. Journal of Advanced Nursing 67, 401407.CrossRefGoogle ScholarPubMed
Ferwerda, J, de Boer, K, van der Gaag, M (2010). Metacognitive training for patients with psychotic vulnerability [in Dutch]. Directieve Therapie 30, 263279.Google Scholar
Fine, C, Gardner, M, Craigie, J, Gold, I (2007). Hopping, skipping or jumping to conclusions? Clarifying the role of the JTC bias in delusions. Cognitive Neuropsychiatry 12, 4677.Google Scholar
Freeman, D (2007). Suspicious minds: the psychology of persecutory delusions. Clinical Psychology Review 27, 425457.Google Scholar
Garety, PA, Kuipers, E, Fowler, D, Freeman, D, Bebbington, PE (2001). A cognitive model of the positive symptoms of psychosis. Psychological Medicine 3, 189195.Google Scholar
Gould, RA, Mueser, KT, Bolton, E, Mays, V, Goff, D (2004). Cognitive therapy for psychosis and schizophrenia: an effect size analysis. Focus 2, 95101.Google Scholar
Green, CE, Freeman, D, Kuipers, E, Bebbington, P, Fowler, D, Dunn, G, Garety, PA (2008). Measuring ideas of persecution and social reference: the Green et al. Paranoid Thought Scales (GPTS). Psychological Medicine 38, 101111.Google Scholar
Haddock, G, McCarron, J, Tarrier, N, Faragher, EB (1999). Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychological Medicine 29, 879889.Google Scholar
Hakkaart-van Roijen, L, van Straten, A, Donker, M, Tiemens, M (2002). Trimbos/iMTA Questionnaire for Costs Associated with Psychiatric Illness (TiC-P) . iMTA Report No. 02.61. Institute for Medical Technology Assessment: Rotterdam.Google Scholar
Kumar, D, Zia-ul-Haq, M, Dubey, I, Dotivala, KN, Siddiqui, SV, Prakash, R, Abhishek, P, Nizamie, SH (2010). Effect of meta-cognitive training in the reduction of positive symptoms in schizophrenia. European Journal of Psychotherapy, Counseling and Health 12, 149158.Google Scholar
Lincoln, TM, Mehl, S, Exner, C, Lindenmeyer, J, Rief, W (2010). Attributional style and persecutory delusions. Evidence for an event independent and state specific external-personal attribution bias for social situations. Cognitive Therapy Research 34, 297302.Google Scholar
Liraud, F, Droulout, T, Parrot, M, Verdoux, H (2004). Agreement between self-rated and clinically assessed symptoms in subjects with psychosis. Journal of Nervous and Mental Disease 192, 352356.Google Scholar
Moritz, S, Kerstan, A, Veckenstedt, R, Randjbar, S, Vitzhum, F, Schmidt, C, Heise, M, Woodward, TS (2011 a). Further evidence for the efficacy of a metacognitive group training in schizophrenia. Behaviour Research and Therapy 49, 151157.Google Scholar
Moritz, S, Veckenstedt, R, Randjbar, S, Vitzhum, F (2011 b). Individualized Metacognitive Therapy for Persons with Psychosis. Springer-Verlag: Heidelberg.Google Scholar
Moritz, S, Veckenstedt, R, Randjbar, S, Vitzthum, F, Woodward, TS (2011 c). Antipsychotic treatment beyond antipsychotics: metacognitive intervention for schizophrenia patients improves delusional symptoms. Psychological Medicine 41, 18231832.Google Scholar
Moritz, S, Woodward, TS (2006 a). Metacognitive control over false memories: a key determinant of delusional thinking. Current Psychiatry Report 8, 184190.Google Scholar
Moritz, S, Woodward, TS (2006 b). A generalized bias against disconfirmatory evidence in schizophrenia. Psychiatry Research 142, 157165.Google Scholar
Moritz, S, Woodward, TS (2007). Metacognitive training in schizophrenia: from basic research to knowledge translation and intervention. Current Opinion in Psychiatry 20, 619625.Google Scholar
Moritz, S, Woodward, TS, Burlon, M, Braus, DF, Andresen, B (2006). Attributional style in schizophrenia: evidence for a decreased sense of self-causation in currently paranoid patients. Cognitive Therapy Research 31, 371383.Google Scholar
Moritz, S, Woodward, TS, Cuttler, C, Whitman, JC, Watson, JM (2004). False memories in schizophrenia. Neuropsychology 18, 276283.Google Scholar
Morrison, AP (2001). The interpretation of intrusions in psychosis: an integrative cognitive model approach to hallucinations and delusions. Behavioural and Cognitive Psychotherapy 29, 257276.Google Scholar
NICE (2009). Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Primary and Secondary Care (Update) . Clinical guidelines, CG82. National Institute of Clinical Excellence: London, UK.Google Scholar
Riggs, SE, Grant, PM, Perivoliotis, D, Beck, AT (2012). Assessment of cognitive insight: a qualitative review. Schizophrenia Bulletin 38, 338350.Google Scholar
Ross, K, Freeman, D, Dunn, G, Garety, P (2011). A randomized experimental investigation of reasoning training for people with delusions. Schizophrenia Bulletin 37, 324333.Google Scholar
So, SH, Freeman, D, Dunn, G, Kapur, S, Kuipers, E, Bebbington, P, Fowler, D, Garety, PA (2012). Jumping to conclusions, a lack of belief flexibility and delusional conviction in psychosis: a longitudinal investigation of the structure, frequency, and relatedness of reasoning biases. Journal of Abnormal Psychology 121, 129139.Google Scholar
Spada, MM, Mohiyeddini, C, Wells, A (2008). Measuring metacognitions associated with emotional distress: factor structure and predictive validity of the Metacognitions Questionnaire. Personality and Individual Differences 3, 238242.Google Scholar
van der Gaag, M (2006). A neuropsychiatric model of biological and psychological processes in the remission of delusions and auditory hallucinations. Schizophrenia Bulletin 32, 113122.Google Scholar
van der Gaag, M, Schütz, C, Ten Napel, A, Landa, J, Delespaul, P, Bak, M, Tschacher, W, de Hert, M (2013). Development of the Davos assessment of cognitive biases scale (DACOBS). Schizophrenia Research 144, 6371.Google Scholar
Villeneuve, K, Potvin, S, Lesage, A, Nicole, L (2010). Meta-analysis of rates of drop-out from psychosocial treatment among persons with schizophrenia spectrum disorder. Schizophrenia Research 121, 266270.Google Scholar
Wells, A, Cartwright-Hatton, S (2004). A short form of the Metacognitions Questionnaire: properties of the MCQ-30. Behaviour Research and Therapy 42, 385396.Google Scholar
WHO (1999). Schedules for Clinical Assessment in Neuropsychiatry. SCAN 2.1. World Health Organization: Geneva.Google Scholar
Woods, SW (2003). Chlorpromazine equivalent doses for the newer atypical antipsychotics. Journal of Clinical Psychology 64, 663667.Google Scholar
Woodward, TS, Moritz, S, Chen, EY (2006 a). The contribution of a cognitive bias against disconfirmatory evidence (BADE) to delusions: a study in an Asian sample with first episode schizophrenia spectrum disorders. Schizophrenia Research 83, 297298.Google Scholar
Woodward, TS, Moritz, S, Cuttler, C, Whitman, JC (2006 b). The contribution of a cognitive bias against disconfirmatory evidence (BADE) to delusions in schizophrenia. Journal of Clinical and Experimental Neuropsychology 28, 605617.Google Scholar
Wykes, T, Steel, C, Everitt, B, Tarrier, N (2008). Cognitive behavior therapy for schizophrenia: effect sizes, clinical models and methodological rigor. Schizophrenia Bulletin 34, 523537.Google Scholar
Xia, J, Merinder, LB, Belgamwar, MR (2011). Psychoeducation for schizophrenia. Cochrane Database of Systematic Reviews. Issue 6, Art. No. CD002831.Google Scholar