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The long-term risk of recognized and unrecognized myocardial infarction for depression in older men

Published online by Cambridge University Press:  21 March 2016

O. Jovanova ,
A. I. Luik ,
M. J. G. Leening ,
R. Noordam ,
N. Aarts ,
A. Hofman ,
O. H. Franco ,
A. Dehghan  and
H. Tiemeier
O. Jovanova
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
A. I. Luik
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
M. J. G. Leening
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Cardiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
R. Noordam
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
N. Aarts
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
A. Hofman
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
O. H. Franco
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
A. Dehghan
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
H. Tiemeier*
Affiliation:
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
*
*Address for correspondence: H. Tiemeier, MD, PhD, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. (Email: [email protected])
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Abstract

Background

The association between myocardial infarction (MI) and depression is well described. Yet, the underlying mechanisms are unclear and the contribution of psychological factors is uncertain. We aimed to determine the risk of recognized (RMI) and unrecognized (UMI) myocardial infections on depression, as both have a similar impact on cardiovascular health but differ in psychological epiphenomena.

Method

Participants of the Rotterdam Study, 1823 men aged ⩾55 years, were followed for the occurrence of depression. RMI and UMI were ascertained using electrocardiography and medical history at baseline. We determined the strength of the association of RMI and UMI with mortality, and we studied the relationship of RMI and UMI with depressive symptoms and the occurrence of major depression.

Results

The risk of mortality was similar in men with RMI [adjusted hazard ratio (aHR) 1.71, 95% confidence interval (CI) 1.45–2.03] and UMI (aHR 1.58, 95% CI 1.27–1.97). Men with RMI had on average [unstandardized regression coefficient (B) 1.14, 95% CI 0.07–2.21] higher scores for depressive symptoms. By contrast, we found no clear association between UMI and depressive symptoms (B 0.55, 95% CI −0.51 to 1.62) in men. Analysis including occurrence of major depression as the outcome were consistent with the pattern of association.

Conclusion

The discrepant association of RMI and UMI with mortality compared to depression suggests that the psychological burden of having experienced an MI contributes to the long-term risk of depression.

Keywords

Depressionepidemiologymyocardial infarctionpopulation based
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 9 , July 2016 , pp. 1951 - 1960
Copyright
Copyright © Cambridge University Press 2016 

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References

Barsky, AJ, Hochstrasser, B, Coles, NA, Zisfein, J, O'Donnell, C, Eagle, KA (1990). Silent myocardial ischemia. Is the person or the event silent? Journal of the American Medical Association 264, 1132–1135.CrossRefGoogle ScholarPubMed
Beekman, AT, Deeg, DJ, Van Limbeek, J, Braam, AW, De Vries, MZ, Van Tilburg, W (1997). Criterion validity of the Center for Epidemiologic Studies Depression scale (CES-D): results from a community-based sample of older subjects in The Netherlands. Psychological Medicine 27, 231–235.CrossRefGoogle Scholar
Bjelland, I, Dahl, AA, Haug, TT, Neckelmann, D (2002). The validity of the hospital anxiety and depression scale. An updated literature review. Journal of Psychosomatic Research 52, 69–77.CrossRefGoogle ScholarPubMed
Breslau, N (1985). Depressive symptoms, major depression, and generalized anxiety: a comparison of self-reports on CES-D and results from diagnostic interviews. Psychiatry Research 15, 219–229.CrossRefGoogle ScholarPubMed
Cabin, HS, Roberts, WC (1982). Quantitative comparison of extent of coronary narrowing and size of healed myocardial infarct in 33 necropsy patients with clinically recognized and in 28 with clinically unrecognized (‘silent’) previous acute myocardial infarction. American Journal of Cardiology 50, 677–681.CrossRefGoogle ScholarPubMed
Cohn, PF, Fox, KM, Daly, C (2003). Silent myocardial ischemia. Circulation 108, 1263–1277.CrossRefGoogle ScholarPubMed
Dehghan, A, Kardys, I, de Maat, MP, Uitterlinden, AG, Sijbrands, EJ, Bootsma, AH, Stijnen, T, Hofman, A, Schram, MT, Witteman, JC (2007). Genetic variation, C-reactive protein levels, and incidence of diabetes. Diabetes 56, 872–878.CrossRefGoogle ScholarPubMed
Dehghan, A, Leening, MJ, Solouki, AM, Boersma, E, Deckers, JW, van Herpen, G, Heeringa, J, Hofman, A, Kors, JA, Franco, OH, Ikram, MA, Witteman, JC (2014). Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study). American Journal of Cardiology 113, 1–6.CrossRefGoogle ScholarPubMed
Denollet, J, Strik, JJ, Lousberg, R, Honig, A (2006). Recognizing increased risk of depressive comorbidity after myocardial infarction: looking for 4 symptoms of anxiety-depression. Psychotherapy and Psychosomatics 75, 346–352.CrossRefGoogle ScholarPubMed
de Torbal, A, Boersma, E, Kors, JA, van Herpen, G, Deckers, JW, van der Kuip, DA, Stricker, BH, Hofman, A, Witteman, JC (2006). Incidence of recognized and unrecognized myocardial infarction in men and women aged 55 and older: the Rotterdam Study. European Heart Journal 27, 729–736.CrossRefGoogle ScholarPubMed
Drory, Y, Kravetz, S, Hirschberger, G, Israeli Study Group on First Acute Myocardial I (2002). Long-term mental health of men after a first acute myocardial infarction. Archives of Physical Medicine and Rehabilitation 83, 352–359.CrossRefGoogle ScholarPubMed
Folstein, MF, Folstein, SE, McHugh, PR (1975). ‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189–198.CrossRefGoogle Scholar
Frasure-Smith, N, Lesperance, F, Talajic, M (1993). Depression following myocardial infarction. Impact on 6-month survival. Journal of the American Medical Association 270, 1819–1825.CrossRefGoogle ScholarPubMed
Harrison, NA, Cooper, E, Voon, V, Miles, K, Critchley, HD (2013). Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression? Brain, Behavior, and Immunity 31, 189–196.CrossRefGoogle ScholarPubMed
Hofman, A, Darwish Murad, S, van Duijn, CM, Franco, OH, Goedegebure, A, Ikram, MA, Klaver, CC, Nijsten, TE, Peeters, RP, Stricker, BH, Tiemeier, HW, Uitterlinden, AG, Vernooij, MW (2013). The Rotterdam Study: 2014 objectives and design update. European Journal of Epidemiology 28, 889–926.CrossRefGoogle ScholarPubMed
Ikram, MA, Hollander, M, Bos, MJ, Kors, JA, Koudstaal, PJ, Hofman, A, Witteman, JC, Breteler, MM (2006). Unrecognized myocardial infarction and the risk of stroke: the Rotterdam Study. Neurology 67, 1635–1639.CrossRefGoogle ScholarPubMed
Ikram, MA, van Oijen, M, de Jong, FJ, Kors, JA, Koudstaal, PJ, Hofman, A, Witteman, JC, Breteler, MM (2008). Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease. Stroke 39, 1421–1426.CrossRefGoogle ScholarPubMed
Kannel, WB, Abbott, RD (1984). Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. New England Journal of Medicine 311, 1144–1147.CrossRefGoogle ScholarPubMed
Krijthe, BP, Leening, MJ, Heeringa, J, Kors, JA, Hofman, A, Franco, OH, Witteman, JC, Stricker, BH (2013). Unrecognized myocardial infarction and risk of atrial fibrillation: the Rotterdam Study. International Journal of Cardiology 168, 1453–1457.CrossRefGoogle ScholarPubMed
Kumar, V, Abbas, AK, Aster, JC (2012). Robbins Basic Pathology. Elsevier Canada: Toronto.Google Scholar
Ladwig, KH, Roll, G, Breithardt, G, Budde, T, Borggrefe, M (1994). Post-infarction depression and incomplete recovery 6 months after acute myocardial infarction. Lancet 343, 20–23.CrossRefGoogle ScholarPubMed
Larsen, KK (2013). Depression following myocardial infarction – an overseen complication with prognostic importance. Danish Medical Journal 60, B4689.Google ScholarPubMed
Leening, MJ, Elias-Smale, SE, Felix, JF, Kors, JA, Deckers, JW, Hofman, A, Stricker, BH, Witteman, JC (2010). Unrecognised myocardial infarction and long-term risk of heart failure in the elderly: the Rotterdam Study. Heart 96, 1458–1462.CrossRefGoogle ScholarPubMed
Leening, MJ, Kavousi, M, Heeringa, J, van Rooij, FJ, Verkroost-van Heemst, J, Deckers, JW, Mattace-Raso, FU, Ziere, G, Hofman, A, Stricker, BH, Witteman, JC (2012). Methods of data collection and definitions of cardiac outcomes in the Rotterdam Study. European Journal of Epidemiology 27, 173–185.CrossRefGoogle ScholarPubMed
Lesperance, F, Frasure-Smith, N (2000). Depression in patients with cardiac disease: a practical review. Journal of Psychosomatic Research 48, 379–391.CrossRefGoogle ScholarPubMed
Lesperance, F, FrasureSmith, N, Talajic, M (1996). Major depression before and after myocardial infarction: its nature and consequences. Psychosomatic Medicine 58, 99–110.CrossRefGoogle ScholarPubMed
Lloyd, GG, Cawley, RH (1982). Psychiatric morbidity after myocardial infarction. Quarterly Journal of Medicine 51, 33–42.Google ScholarPubMed
Luijendijk, HJ, van den Berg, JF, Dekker, MJ, van Tuijl, HR, Otte, W, Smit, F, Hofman, A, Stricker, BH, Tiemeier, H (2008). Incidence and recurrence of late-life depression. Archives of General Psychiatry 65, 1394–1401.CrossRefGoogle ScholarPubMed
Lumley, MA, Torosian, T, Rowland, LL, Ketterer, MW, Pickard, SD (1997). Correlates of unrecognized acute myocardial infarction detected via perfusion imaging. American Journal of Cardiology 79, 1170–1173.CrossRefGoogle ScholarPubMed
Macleod, J, Davey Smith, G, Heslop, P, Metcalfe, C, Carroll, D, Hart, C (2002). Psychological stress and cardiovascular disease: empirical demonstration of bias in a prospective observational study of Scottish men. British Medical Journal 324, 1247–1251.CrossRefGoogle Scholar
Murabito, JM, Evans, JC, Larson, MG, Levy, D (1993). Prognosis after the onset of coronary heart disease. An investigation of differences in outcome between the sexes according to initial coronary disease presentation. Circulation 88, 2548–2555.CrossRefGoogle ScholarPubMed
Park, MW, Park, SH, Kwak, DJ, Sung, YM (2012). Effects of substrate heating on the photovoltaic characteristics of dye-sensitized solar cells during two-step Ti film deposition by RF magnetron sputtering. Journal of Nanoscience and Nanotechnology 12, 3309–3312.CrossRefGoogle ScholarPubMed
Piyavhatkul, N, Krisanaprakornkit, T, Paholpak, S, Khiewyou, J (2008). Validity and reliability of WHO Schedules for Clinical Assessment in Neuropsychiatry (SCAN)-Thai version: cognitive Impairment or Decline Section. Journal of the Medical Association of Thailand 91, 1129–1136.Google ScholarPubMed
Polsky, D, Doshi, JA, Marcus, S, Oslin, D, Rothbard, A, Thomas, N, Thompson, CL (2005). Long-term risk for depressive symptoms after a medical diagnosis. Archives of Internal Medicine 165, 1260–1266.CrossRefGoogle ScholarPubMed
Ravven, S, Bader, C, Azar, A, Rudolph, JL (2013). Depressive symptoms after CABG surgery: a meta-analysis. Harvard Review of Psychiatry 21, 59–69.CrossRefGoogle ScholarPubMed
Schelbert, EB, Cao, JJ, Sigurdsson, S, Aspelund, T, Kellman, P, Aletras, AH, Dyke, CK, Thorgeirsson, G, Eiriksdottir, G, Launer, LJ, Gudnason, V, Harris, TB, Arai, AE (2012). Prevalence and prognosis of unrecognized myocardial infarction determined by cardiac magnetic resonance in older adults. Journal of the American Medical Association 308, 890–896.CrossRefGoogle ScholarPubMed
Sheifer, SE, Manolio, TA, Gersh, BJ (2001). Unrecognized myocardial infarction. Annals of Internal Medicine 135, 801–811.CrossRefGoogle ScholarPubMed
Steg, PG, James, SK, Atar, D, Badano, LP, Blomstrom-Lundqvist, C, Borger, MA, Di Mario, C, Dickstein, K, Ducrocq, G, Fernandez-Aviles, F, Gershlick, AH, Giannuzzi, P, Halvorsen, S, Huber, K, Juni, P, Kastrati, A, Knuuti, J, Lenzen, MJ, Mahaffey, KW, Valgimigli, M, van ‘t Hof, A, Widimsky, P, Zahger, D (2012). ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal 33, 2569–2619.Google ScholarPubMed
Stern, S (2005). Symptoms other than chest pain may be important in the diagnosis of ‘silent ischemia’, or ‘the sounds of silence’. Circulation 111, e435–e437.CrossRefGoogle ScholarPubMed
Stokes, J III, Dawber, TR (1959). The silent coronary: the frequency and clinical characteristics of unrecognized myocardial infarction in the Framingham study. Annals of Internal Medicine 50, 1359–1369.Google ScholarPubMed
Thombs, BD, Bass, EB, Ford, DE, Stewart, KJ, Tsilidis, KK, Patel, U, Fauerbach, JA, Bush, DE, Ziegelstein, RC (2006). Prevalence of depression in survivors of acute myocardial infarction. Journal of General Internal Medicine 21, 30–38.CrossRefGoogle ScholarPubMed
Tiemeier, H, Hofman, A, van Tuijl, HR, Kiliaan, AJ, Meijer, J, Breteler, MM (2003). Inflammatory proteins and depression in the elderly. Epidemiology 14, 103–107.CrossRefGoogle ScholarPubMed
Trivedi, MH (2004). The link between depression and physical symptoms. Prim Care Companion. Journal of Clinical Psychiatry 6, 12–16.Google ScholarPubMed
van Bemmel, JH, Kors, JA, van Herpen, G (1990). Methodology of the modular ECG analysis system MEANS. Methods of Information in Medicine 29, 346–353.Google ScholarPubMed
Wieberdink, RG, Ikram, MA, Hofman, A, Koudstaal, PJ, Breteler, MM (2012). Trends in stroke incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008. European Journal of Epidemiology 27, 287–295.CrossRefGoogle ScholarPubMed
Wiles, R (1998). Patients’ perceptions of their heart attack and recovery: the influence of epidemiological ‘evidence’ and personal experience. Social Science & Medicine 46, 1477–1486.CrossRefGoogle ScholarPubMed
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