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Long-latency auditory event-related potentials in schizophrenia and in bipolar and unipolar affective disorder

Published online by Cambridge University Press:  09 July 2009

Walter J. Muir ,
David M. St. Clair  and
Douglas H. R. Blackwood
Walter J. Muir*
Affiliation:
Department of Psychiatry, University of Edinburgh
David M. St. Clair
Affiliation:
Department of Psychiatry, University of Edinburgh
Douglas H. R. Blackwood
Affiliation:
Department of Psychiatry, University of Edinburgh
*
1Address for correspondence: Dr Walter J. Muir, Department of Psychiatry, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF.
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Synopsis

Long-latency auditory event-related potentials were examined in 96 subjects with schizophrenia, 99 with bipolar affective disorder and 48 with major depressive (unipolar) disorder, and compared with 32 in-patient and 213 normal controls. The latency of the P3 component was significantly greater in the schizophrenic and bipolar subjects compared to other groups. The difference was stable with respect to clinical state at the time of testing and was not due to age differences or the effect of psychotropic medications. The results support the clinical distinction between bipolar and unipolar affective disorders, but also show that P3 change is not specific to schizophrenia and found in bipolar but not unipolar affective disorder.

Type
Original Articles
Information
Psychological Medicine , Volume 21 , Issue 4 , November 1991 , pp. 867 - 879
Copyright
Copyright © Cambridge University Press 1991

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References

Allen, M. G. (1976). Twin studies of affective illness. Archives of General Psychiatry 33, 1476–1478.CrossRefGoogle ScholarPubMed
American Psychiatric Association Committee on Nomenclature and Statistics. (1987). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, Revised. American Psychiatric Association: Washington DC.Google Scholar
Angst, J. (1966). Zür Ätiologie und Nosologie endogener depressiver Psychosen. Monographien aus dem Gesamtgebiete der Neurologie und Psychiatrie, no. 112. Springer-Verlag: Berlin.CrossRefGoogle Scholar
Angst, J., Baastrup, P., Grof, P., Hippius, H., Poldinger, W. & Weis, p. (1973). The course of monopolar depression and bipolar psychoses. Psychiatria Neurologia Neurochirurgia 76, 489–500.Google ScholarPubMed
Baribeau-Brown, J., Picton, T. W. & Goselin, Y. Y. (1983). Schizophrenia: a neurophysiological evaluation of abnormal information processing. Science 219, 874–876.CrossRefGoogle Scholar
Berger, M., Pirke, K. M., Doerr, P., Krieg, J. C. & Von Zerssen, D. (1984). The limited utility of the dexamethasone suppression test for the diagnostic process in psychiatry. British Journal of Psychiatry 145, 372–382.CrossRefGoogle ScholarPubMed
Berger, P. A., Faull, K. F., Kilkowski, J., Anderson, P. J., Kraemer, H., Davis, K. L. & Barchas, J. D. (1980). CSF monoamine metabolites in depression and schizophrenia. American Journal of Psychiatry 137, 174–180.Google ScholarPubMed
Bertelsen, A., Harvald, B. & Hauge, M. (1977). A Danish twin study of manic-depressive disorders. British Journal of Psychiatry 130, 330–351.CrossRefGoogle ScholarPubMed
Blackwood, D. H. R., St. Clair, D. M. & Kutcher, S. P. (1986). P300 event-related potential abnormalities in borderline personality disorder. Biological Psychiatry 21, 560–564.CrossRefGoogle ScholarPubMed
Blackwood, D. H. R., Whalley, L. J., Christie, J. E., Blackburn, I. M., St. Clair, D. M. & McInnes, A. (1987). Changes in auditory P3 event-related potential in schizophrenia and depression. British Journal of Psychiatry 150, 154–160.CrossRefGoogle ScholarPubMed
Blackwood, D. H. R., St. Clair, D. M., Muir, W. J., Oliver, C. J. & Dickens, P. (1988). The development of Alzheimer's disease in Down's syndrome assessed by auditory event-related potentials. Journal of Mental Deficiency Research 32, 439–453.Google ScholarPubMed
Bogerts, B., Meertz, E. & Schonfeldt-Bausch, R. (1985). Basal ganglia and limbic system pathology in schizophrenia; a morphometric study. Archives of General Psychiatry 42, 784–791.CrossRefGoogle ScholarPubMed
Braddock, L. (1986). The dexamethasone suppression test; fact and artefact. British Journal of Psychiatry 148, 363–374.CrossRefGoogle ScholarPubMed
Brecher, M. & Begleiter, H. (1983). Event-related brain potentials to high-incentive stimuli in unmedicated schizophrenic patients. Biological Psychiatry 18, 661–674.Google ScholarPubMed
Buchsbaum, M., Landau, S., Murphy, D. & Goodwin, F. (1973). Average evoked response in bipolar and unipolar affective disorders; relationships to sex, age of onset, and monoamine oxidase. Biological Psychiatry 7, 199–211.Google ScholarPubMed
Buchsbaum, M. S., Carpenter, W. T., Fedio, P., Goodwin, F. K., Murphy, D. L. & Post, R. N. (1979). Hemispheric differences in evoked potential enhancement by selective attention to hemiretinally presented stimuli in schizophrenic affective and post-temporal lobectomy patients. In Hemisphere Asymmetries of Function in Psychopathology (ed. Gruzelier, J. and Flor-Henry, P.), pp. 317–328. Elsevier: Amsterdam.Google Scholar
Crow, T. J. (1986). The continuum of psychosis and its implication for the structure of the gene. British Journal of Psychiatry 149, 419–429.CrossRefGoogle ScholarPubMed
Davis, K. L., Davidson, M., Mohs, R. C., Kendler, K. S., Davis, B. M., Johns, C. A., DeNigris, Y. & Hovarth, T. B. (1985). Plasma homovanillic acid concentration and the severity of schizophrenic illness. Science 227, 1601–1602.CrossRefGoogle ScholarPubMed
Diner, B. C., Holcomb, P. J. & Dykman, R. A. (1985). P300 in major depressive disorder. Psychiatry Research 15, 175–184.CrossRefGoogle ScholarPubMed
Endicott, J. & Spitzer, R. L. (1978). A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry 35, 837–844.CrossRefGoogle ScholarPubMed
Falkai, P. & Bogerts, B. (1986). Cell loss in the hippocampus of schizophrenics. European Archives of Psychiatry and Neurological Science 236, 154–161.CrossRefGoogle ScholarPubMed
Faux, S. F., Torello, M. W., McCarley, R. W., Shenton, M. E. & Duffy, F. H. (1988). P300 in schizophrenia: confirmation and statistical validation of temporal region deficit in P300 topography. Biological Psychiatry 23, 776–790.CrossRefGoogle ScholarPubMed
Flor-Henry, P. (1983). The Cerebral Basis of Psychopathology, pp. 26–34. John Wright: London.Google Scholar
Friedman, J. & Meares, R. (1979). The effects of placebo and tricyclic antidepressants on cortical evoked potentials in depressed patients. Biological Psychiatry 8, 291–302.CrossRefGoogle ScholarPubMed
Goodin, D. S., Squires, K. C. & Starr, A. (1978). Long latency event-related components of the auditory evoked potential in dementia. Brain 101, 635–648.CrossRefGoogle ScholarPubMed
Gunderson, J. G., Kolb, J. E., & Austin, V. (1981). The diagnostic interview for borderline patients. American Journal of Psychiatry 138, 896–903.Google ScholarPubMed
Halgren, E., Squires, N. K., Wilson, C. L., Rohrbaugh, J. W., Babe, T. L. & Crandall, P. H. (1974). Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events. Science 210, 803–805.CrossRefGoogle Scholar
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 59–61.CrossRefGoogle ScholarPubMed
Holzman, P. S., Proctor, L. R. & Hughes, D. W. (1973). Eye tracking patterns in schizophrenia. Science 181, 179–181.CrossRefGoogle ScholarPubMed
Holzman, P. S., Proctor, L. R., Levy, D. L., Yasillo, N. J., Meltzer, H. Y. & Hurt, S. W. (1974). Eye tracking dysfunction in schizophrenic patients and their relatives. Archives of General Psychiatry 31, 143–151.CrossRefGoogle ScholarPubMed
Holzman, P. S., Solomon, C. M., Levin, S. & Waternaux, C. S. (1984). Pursuit eye movement dysfunction in schizophrenia. Archives of General Psychiatry 41, 136–139.CrossRefGoogle ScholarPubMed
Iacono, W. G., Tuason, V. B. & Johnson, R. A. (1981). Dissociation of the smooth-pursuit and saccadic eye tracking in remitted schizophrenics. Archives of General Psychiatry 38, 991–996.CrossRefGoogle ScholarPubMed
Iacono, W. G., Peloquin, L. J., Lumry, A. E., Valentine, R. H. & Tuason, V. B. (1982). Eye tracking in patients with unipolar and bipolar affective disorders in remission. Journal of Abnormal Psychology 1, 35–44.CrossRefGoogle Scholar
Johnson, R. Jr. & Fedio, P. (1984). ERP and P300 activity in patients following unilateral temporal lobectomy Society for Neuroscience Symposia Abstracts, 10, 847.Google Scholar
Kendell, R. E. & Brockington, I. F. (1980). The identification of disease entities and the relationship between schizophrenic and affective psychoses. British Journal of Psychiatry 137, 324–331.CrossRefGoogle ScholarPubMed
Kendell, R. E. & Gourlay, J. (1970). The clinical distinction between the affective psychoses and schizophrenia. British Journal of Psychiatry 117, 257–260.CrossRefGoogle Scholar
Koslow, S. H., Maas, J. W., Bowden, C. L., Davis, J. M., Hanen, I. & Javaid, J. I. (1983). CSF and urinary biogenic amines and metabolites in depression and mania. Archives of General Psychiatry 40, 999–1010.CrossRefGoogle ScholarPubMed
Kraepelin, E. (1919). Dementia Praecox and Paraphrenia (translated by Barclay, R. M.), pp. 260–270. E. & S. Livingstone: Edinburgh.Google Scholar
Kutcher, S. P., Blackwood, D. H. R., St. Clair, D. M., Gaskell, D. F. & Muir, W. J. (1987). Auditory P300 in borderline personality disorder and schizophrenia. Archives of General Psychiatry 44, 645–650.CrossRefGoogle Scholar
Lake, R. L., Kleinman, J. E., Kafka, M. S., Ko, G. N., Moore, S. S. & Ziegler, M. (1987). Norepinephrine metabolism in schizophrenia. In Handbook of Schizophrenia, Vol. 2, Neurochemistry and Neuropharmacology of Schizophrenia (ed. Nasrallah, H. A.), pp. 227–256. Elsevier: Amsterdam.Google Scholar
Leonhard, K. (1957). The Classification of Endogenous Psychoses Aufteiling der Endogenen Psychosen 8th edn. (English translation by Berman, R.) Irvington: New York. (1979).Google Scholar
Levin, S., Jones, A., Stark, L., Merrin, E. L. & Holzman, P. S. (1982). Identification of abnormal patterns in eye movements of schizophrenic patients. Archives of General Psychiatry 39, 1125–1130.CrossRefGoogle ScholarPubMed
Levit, R. A., Sutton, S. & Zubin, J. (1973). Evoked potential correlates of information processing in psychiatric patients. Psychological Medicine 3, 487–494.CrossRefGoogle ScholarPubMed
Levy, D. L., Lipton, R. B., Holzman, P. S. & Davis, J. M. (1983). Eye tracking dysfunction unrelated to clinical state and treatment with haloperidol Biological Psychiatry 18, 813–819.Google ScholarPubMed
Levy, D. L., Dorus, E., Shaughnessy, R., Yasillo, N. J., Pandey, G. N., Janicak, P. G., Gibbons, R. F., Gaviria, M. & Davis, J. M. (1985). Pharmacological evidence for specificity of pursuit dysfunction to schizophrenia: lithium carbonate associated with abnormal pursuit. Archives of General Psychiatry 42, 335–341.CrossRefGoogle ScholarPubMed
Lipton, R. B., Frost, L. & Holzman, P. S. (1980 a). Smooth pursuit eye movements, schizophrenia and distraction. Perception and Motor Skills 50, 159–167.Google ScholarPubMed
Lipton, R. B., Levin, S. & Holzman, P. S. (1980 b). Horizontal and vertical pursuit eye movements, the oculocephalic reflex and the functional psychoses. Psychiatry Research 3, 193–203.CrossRefGoogle ScholarPubMed
McCarthy, G., Wood, C. C., Allison, T., Goff, W. R., Williamson, P. D. & Spencer, D. D. (1982). Intracranial recordings of event-related potentials in humans engaged in cognitive tasks. Neuroscience Abstracts 8, 976.Google Scholar
Maj, M., Ariano, M. G., Pirozzi, R., Salvati, A. & Kemali, D. (1984). Platelet monoamine oxidase activity in schizophrenia: relationship to family history of the illness and neuroleptic treatment. Journal of Psychiatry Research 18, 131–137.CrossRefGoogle ScholarPubMed
Medical Research Council; Drug Trials Subcommittee. (1981). Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a controlled clinical trial. Psychological Medicine 11, 409–416.CrossRefGoogle Scholar
Morstyn, R., Duffy, F. H. & McCarley, R. W. (1983). Altered P300 topography in schizophrenia. Archives of General Psychiatry 40, 729–734.CrossRefGoogle ScholarPubMed
Muir, W. J., Squire, I., Blackwood, D. H. R., Speight, M. D., St. Clair, D. M., Oliver, C. & Dickens, P. (1988). Auditory P300 response in the assessment of Alzheimer's disease in Down's syndrome: a 2-year follow-up study. Journal of Mental Deficiency Research 32, 455–463.Google ScholarPubMed
Murphy, D. L. & Weiss, R. (1972). Reduced monoamine oxidase activity in blood platelets from bipolar depressed patients. American Journal of Psychiatry 128, 1351–1357.CrossRefGoogle ScholarPubMed
Murphy, D. L. & Wyatt, R. J. (1972). Reduced monoamine oxidase activity in blood platelets from schizophrenic patients. Nature 238, 225–226.CrossRefGoogle ScholarPubMed
Nasrallah, H. A., McCalley-Whitters, M. & Jacoby, C. G. (1982). Cerebral ventricular enlargement in young manic males. Journal of Affective Disorders 4, 15–19.CrossRefGoogle ScholarPubMed
Okada, Y. C., Kaufman, L. & Williamson, S. J. (1983). The hippocampal formation as a source of slow endogenous potentials Electroencephalography and Clinical Neurophysiology 55, 417–427.CrossRefGoogle ScholarPubMed
Pass, H. L., Klorman, R., Salzman, L. F., Klein, R. H. & Kaskey, G. B. (1980). The late positive component of the evoked response in acute schizophrenics during a test of sustained attention. Biological Psychiatry 15, 209–223.Google ScholarPubMed
Pearlson, G. D. & Veroff, A. E. (1981). Computerized tomographic scan changes in manic-depressive illness. Lancet ii, 470.CrossRefGoogle Scholar
Pearlson, G. D., Garbacz, D. J., Breakey, W. R., Ahn, H. S. & DePaulo, J. R. (1984). Lateral ventricular enlargement associated with persistent unemployment and negative symptoms in both schizophrenia and bipolar disorder. Psychiatry Research 12, 1–9.CrossRefGoogle ScholarPubMed
Pearlson, G. D., Garbacz, D. J., Moberg, P. J., Ahn, H. S. & DePaulo, J. R. (1985). Symptomatic, familial, perinatal, and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. Journal of Nervous and Mental Disease 173, 42–50.CrossRefGoogle ScholarPubMed
Perris, C. (1966). A study of bipolar (manic-depressive) and unipolar depressive psychoses. Acta Phsychiatrica Scandinavica 42, (supplement 194), 1–199.Google Scholar
Pffeferbaum, A., Wenegrat, B. W., Ford, J. M., Roth, W. T. & Kopell, B. S. (1984). Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalography and Clinical Neurophysiology 59, 104–124.CrossRefGoogle Scholar
Polich, J. & Burns, T. (1987). P300 from identical twins. Neuropsychologia 20, 299–304.CrossRefGoogle Scholar
Polich, J., Howard, L. & Starr, A. (1985). Effects of age on the P300 component of event-related potential from auditory stimuli: peak definition, variation and measurement. Journal of Gerontology 40, 721–726.CrossRefGoogle ScholarPubMed
Prien, R. F., Caffey, E. M. & Klett, C. J. (1973). Propylactic efficacy of lithium carbonate in manic-depressive illness. Archives of General Psychiatry 28, 337–351.CrossRefGoogle Scholar
Romani, A., Merello, S., Gorreli, L., Zerri, F., Grassi, M. & Cosi, V. (1987). P300 and CT scan in patients with chronic schizophrenia. British Journal of Psychiatry 151, 306–513.CrossRefGoogle ScholarPubMed
Roth, W. T. & Cannon, E. H. (1972). Some features of the auditory evoked response in schizophrenics. Archives of General Psychiatry 27, 466–471.CrossRefGoogle ScholarPubMed
Roth, W. T., Horvath, T. B., Pfefferbaum, A. & Kopell, B. (1980). Event-related potentials in schizophrenics. Electroencephalography and Clinical Neurophysiology 48, 127–139.CrossRefGoogle ScholarPubMed
Roth, W. T., Pfefferbaum, A., Horvath, T. B., Berger, P. A. & Kopell, B. (1986). P3 reduction in auditory evoked potentials of schizophrenics. Electroencephalography and Clinical Neurophysiology 49, 497–505.CrossRefGoogle Scholar
St. Clair, D. M. & Blackwood, D. H. R. (1985). Premature senility in Down's syndrome. Lancet ii, 34.CrossRefGoogle Scholar
St. Clair, D. M., Blackwood, D. H. R. & Muir, W. J. (1989). P300 abnormality in schizophrenic subtypes. Journal of Psychiatric Research 23, 49–53.CrossRefGoogle ScholarPubMed
Schatzberg, A. F., Rothschild, A. J., Stahl, J. B., Bond, T. C., Rosenbaum, A. H., Lofgren, S. B., McLaughlin, R. A., Sullivan, M. A. & Coles, J. O. (1983). The dexamethasone suppression test: identification of subtypes of depression. American Journal of Psychiatry 140, 88–91.Google ScholarPubMed
Shagass, C., Amadeo, M. & Overton, D. A. (1974). Eye tracking performance in psychiatric patients. Biological Psychiatry 9, 245–260.Google ScholarPubMed
Shagass, C., Straumanis, J. J., Roemer, R. A. & Amadeo, M. (1977). Evoked potentials of schizophrenics in several sensory modalities. Biological Psychiatry 12, 221–231.Google ScholarPubMed
Shagass, C., Roemer, R. A., Straumanis, J. J. & Amadeo, M. (1978). Evoked potential correlates of psychosis. Biological Psychiatry 13, 163–184.Google ScholarPubMed
Shagass, C., Roemer, R. A., Straumanis, J. J. & Amadeo, M. (1979). Spatial distribution of sensory evoked potentials in psychiatric disorders. In Human Evoked Potentials. Applications and Problems (ed. Callaway, E. and Lehmann, P.), pp. 347–362. Plenum Press: New York.CrossRefGoogle Scholar
Shagass, C., Roemer, R. A., Straumanis, J. J. & Amadeo, M. (1980). Topography of sensory evoked potentials in depressive disorders. Biological Psychiatry 15, 183–207.Google ScholarPubMed
Shagass, C., Roemer, R. A. & Straumanis, J. J. (1982). Evoked potential evidence of regional cerebral dysfunction in the major psychoses. In Psychophysiology 1980 (ed. Sinz, R. and Rosenzweig, M. R.), pp. 421–430. Elsevier: Amsterdam.Google Scholar
Silverstone, T. (1985). Dopamine in manic depressive illness: a pharmacological synthesis. Journal of Affective Disorders 8, 225–231.CrossRefGoogle ScholarPubMed
Sklare, D. A. & Lynn, G. E. (1984). Latency of the P3 event-related potential: normative aspects and within subject variability. Electroencephalography and Clinical Neurophysiology 59, 420–424.CrossRefGoogle ScholarPubMed
Spitzer, R. L., Endicott, J. & Robins, E. (1978). Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders, 3rd edn. New York State Psychiatric Institution Biometrics Research: New York.Google Scholar
SPSS-X SPSS incorporated (1986). 444 N. Michigan Avenue; Chicago.Google Scholar
Squires, N. C., Squires, K. C. & Hillyard, S. A. (1975). Two varieties of long latency positive waves evoked by unpredictable auditory stimuli in man. Electroencephalography and Clinical Neurophysiology 38, 387–401.CrossRefGoogle ScholarPubMed
Stahl, S. M. & Wets, K. (1987). Indoleamines and schizophrenia. In Handbook of Schizophrenia, vol. 2, Neurochemistry and Neuropharmacology of Schizophrenia (ed. Nasrallah, H. A.). pp. 257–296 Elsevier: Amsterdam.Google Scholar
Stapleton, J. M., Halgren, E. & Moreno, K. A. (1987). Endogenous potentials after anterior temporal lobe lobectomy. Neuropsychologia 25, 549–557.CrossRefGoogle Scholar
Stokes, P. E., Stoll, P. M., Koslow, S. H., Maas, J. W., Davis, J. M., Swann, A. C. & Robins, E. (1984). Pre-treatment DST and hypothalamic-pituitary adrenocortical function in depressed patients and comparison groups. Archives of General Psychiatry 41, 257–267.CrossRefGoogle Scholar
Straumanis, J. J., Shagass, C. & Roemer, R. A. (1982). Influence of antipsychotic and antidepressant drugs on evoked potential correlates of psychosis. Biological Psychiatry 17, 1101–1122.Google ScholarPubMed
Subrahmanyam, S. (1975). Role of biogenic amines in certain pathological conditions. Brain Research 87, 355–362.CrossRefGoogle ScholarPubMed
Surwillo, W. W. (1980). Cortical evoked potentials in monozygotic twins and unrelated subjects: comparisons of exogenous and endogenous components. Behavioural Genetics 10, 201–209.CrossRefGoogle ScholarPubMed
Sutton, S. & Ruchkin, D. S. (1984). The late positive complex: advances and new problems. Annals of the New York Academy of Sciences 425, 1–23.CrossRefGoogle ScholarPubMed
Tsuang, M. T., Winokur, G. & Crowe, R. R. (1980). Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry 137, 497–504.CrossRefGoogle ScholarPubMed
Tsuang, M. T., Kendler, K. S. & Gruenberg, A. M. (1985). A blind family study of DSM-III schizophrenia. In Genetic Aspects of Human Behavior (ed. Sakai, T., and Tsuboi, T.), pp. 57–61. Igaku-Shoin: Tokyo.Google Scholar
Van Praag, H. M., Korf, J. & Schut, J. (1973). Cerebral monoamines and depression. An investigation with the probenecid technique. Archives of General Psychiatry 28, 827–831.CrossRefGoogle ScholarPubMed
Verleger, R. & Cohen, R. (1978). Effects of certainty, modality shift and guess outcome on evoked potentials and reaction times in chronic schizophrenics. Psychological Medicine 8, 81–93.CrossRefGoogle ScholarPubMed
Vestergaard, P., Sorensen, T., Hoppe, E., Rafaelsen, O. J., Yates, C. M. & Nicolau, N. (1978). Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders. Acta Psychiatrica Scandinavica 58, 88–96.CrossRefGoogle ScholarPubMed
Winokur, G. W., Clayton, P. J. & Reich, T. (1969). Manic Depressive Illness. C. V. Mosby: St. Louis.Google Scholar