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A longitudinal study of the neuropsychiatric consequences of HIV-1 infection in gay men. I Neuropsychological performance and neurological status at baseline and at 12-month follow-up

Published online by Cambridge University Press:  09 July 2009

A. P. Burgess ,
M. Riccio ,
D. Jadresic ,
K. Pugh ,
J. Catalan ,
D. A. Hawkins ,
T. Baldeweg ,
E. Lovett ,
J Gruzelier  and
C. Thompson
A. P. Burgess*
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
M. Riccio
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
D. Jadresic
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
K. Pugh
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
J. Catalan
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
D. A. Hawkins
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
T. Baldeweg
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
E. Lovett
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
J Gruzelier
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
C. Thompson
Affiliation:
Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea and Westminster Hospital, Department of Genito-Urinary Medicine, St Stephen's Clinic, London; Department of Psychiatry, Royal South Hants Hospital, Southampton
*
1Address for correspondence: Mr A. P. Burgess, Academic Department of Psychiatry, Charing Cross and Westminster Medical School, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NG
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Synopsis

The aim of this study was to determine whether HIV infection is associated with neurological or neuropsychological impairment in the asymptomatic and early symptomatic stages of disease. Subjects included 61 gay men (41 HIV −, 20 HIV +) who were assessed at the time of requesting their first HIV test and again 12 months later. The assessments at baseline were conducted double-blind to HIV serostatus. Measures included a neuropsychological battery, neurological examination and full psychiatric assessment. There were no differences between the asymptomatic HIV + and HIV − groups at baseline or at follow-up in terms of mean scores on neuropsychological tests. Mean scores were within the normal range for all neuropsychological tests for both groups. Multiple regression analysis was used to predict each individual's performance at follow-up on the basis of their baseline performance, psychiatric state, neurological history and drug use for each of the neuropsychological tests. HIV + subjects were more likely than control subjects to perform at a significantly lower level at follow-up on one or more tests than predicted on the basis of their baseline performance.

Type
Original Articles
Information
Psychological Medicine , Volume 24 , Issue 4 , November 1994 , pp. 885 - 895
Copyright
Copyright © Cambridge University Press 1994

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