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Life events and borderline personality features: the influence of gene–environment interaction and gene–environment correlation

Published online by Cambridge University Press:  01 July 2010

M. A. Distel ,
C. M. Middeldorp ,
T. J. Trull ,
C. A. Derom ,
G. Willemsen  and
D. I. Boomsma
M. A. Distel*
Affiliation:
Department of Biological Psychology, VU University Amsterdam, The Netherlands
C. M. Middeldorp
Affiliation:
Department of Biological Psychology, VU University Amsterdam, The Netherlands De Bascule, Academic Hospital for Children and Adolescent Psychiatry, Amsterdam, The Netherlands
T. J. Trull
Affiliation:
Department of Psychological Sciences, University of Missouri-Columbia, Columbia, MO, USA
C. A. Derom
Affiliation:
Department of Human Genetics, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
G. Willemsen
Affiliation:
Department of Biological Psychology, VU University Amsterdam, The Netherlands
D. I. Boomsma
Affiliation:
Department of Biological Psychology, VU University Amsterdam, The Netherlands
*
*Address for correspondence: M. A. Distel, Ph.D., Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands. (Email: [email protected])
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Abstract

Background

Traumatic life events are generally more common in patients with borderline personality disorder (BPD) than in non-patients or patients with other personality disorders. This study investigates whether exposure to life events moderates the genetic architecture of BPD features. As the presence of genotype–environment correlation (rGE) can lead to spurious findings of genotype–environment interaction (G×E), we also test whether BPD features increase the likelihood of exposure to life events.

Method

The extent to which an individual is at risk to develop BPD was assessed with the Personality Assessment Inventory – Borderline features scale (PAI-BOR). Life events under study were a divorce/break-up, traffic accident, violent assault, sexual assault, robbery and job loss. Data were available for 5083 twins and 1285 non-twin siblings. Gene–environment interaction and correlation were assessed by using structural equation modelling (SEM) and the co-twin control design.

Results

There was evidence for both gene–environment interaction and correlation. Additive genetic influences on BPD features interacted with the exposure to sexual assault, with genetic variance being lower in exposed individuals. In individuals who had experienced a divorce/break-up, violent assault, sexual assault or job loss, environmental variance for BPD features was higher, leading to a lower heritability of BPD features in exposed individuals. Gene–environment correlation was present for some life events. The genes that influence BPD features thus also increased the likelihood of being exposed to certain life events.

Conclusions

To our knowledge, this study is the first to test the joint effect of genetic and environmental influences and the exposure to life events on BPD features in the general population. Our results indicate the importance of both genetic vulnerability and life events.

Keywords

Borderline personality disordergene–environment correlationgene–environment interactionlife eventstwin studies
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 4 , April 2011 , pp. 849 - 860
Copyright
Copyright © Cambridge University Press 2010

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References

APA (2000). Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Association: Washington, DC.Google Scholar
Bandelow, B, Krause, J, Wedekind, D, Broocks, A, Hajak, G, Ruther, E (2005). Early traumatic life events, parental attitudes, family history, and birth risk factors in patients with borderline personality disorder and healthy controls. Psychiatry Research 134, 169–179.CrossRefGoogle ScholarPubMed
Boomsma, DI, de Geus, EJC, Vink, JM, Stubbe, JH, Distel, MA, Hottenga, JJ, Posthuma, D, van Beijsterveld, CEM, Hudziak, JJ, Bartels, M, Willemsen, G (2006). Netherlands Twin Register: from twins to twin families. Twin Research and Human Genetics 9, 849–857.CrossRefGoogle ScholarPubMed
Boomsma, DI, Martin, NG (2002). Gene–environment interaction. In Biological Psychiatry (ed. D'Haenen, J. A., den Boer, J. A. and Willner, P.), pp. 181–187. John Wiley & Sons, Ltd: Chichester.CrossRefGoogle Scholar
Boomsma, DI, Vink, JM, van Beijsterveldt, TC, de Geus, EJC, Beem, AL, Mulder, EJ, Derks, EM, Riese, H, Willemsen, GA, Bartels, M, van den Berg, M, Kupper, NH, Polderman, TJ, Posthuma, D, Rietveld, MJ, Stubbe, JH, Knol, LI, Stroet, T, van Baal, GC (2002). Netherlands Twin Register: a focus on longitudinal research. Twin Research 5, 401–406.CrossRefGoogle Scholar
Caspi, A, McClay, J, Moffitt, TE, Mill, J, Martin, J, Craig, IW, Taylor, A, Poulton, R (2002). Role of genotype in the cycle of violence in maltreated children. Science 297, 851–854.CrossRefGoogle ScholarPubMed
Cederlof, R, Friberg, L, Lundman, T (1977). The interactions of smoking, environment and heredity and their implications for disease etiology. A report of epidemiological studies on Swedish twin registries. Acta Medica Scandinavica (Suppl.) 612, 1–128.Google ScholarPubMed
De Moor, MHM, Distel, MA, Trull, TJ, Boomsma, DI (2009). Assessment of borderline personality disorder features in population samples: is the Personality Assessment Inventory-Borderline Features scale measurement invariant across sex and age? Psychological Assessment 21, 125–130.CrossRefGoogle ScholarPubMed
Derom, C, Derom, R (2005). The East Flanders Prospective Twin Survey. In Multiple Pregnancy: Epidemiology, Gestation and Perinatal Outcome (ed. Blickstein, I. and Keith, L. G.), pp. 39–47. Taylor & Francis: Oxford.Google Scholar
Derom, CA, Vlietinck, RF, Thiery, EW, Leroy, FOG, Fryns, JP, Derom, RM (2006). The East Flanders Prospective Twin Survey (EFPTS). Twin Research and Human Genetics 9, 733–738.CrossRefGoogle ScholarPubMed
Distel, MA, Hottenga, JJ, Trull, TJ, Boomsma, DI (2008 b). Chromosome 9: linkage for borderline personality disorder features. Psychiatric Genetics 18, 302–307.CrossRefGoogle ScholarPubMed
Distel, MA, Ligthart, L, Willemsen, G, Nyholt, DR, Trull, TJ, Boomsma, DI (2007). Personality, health and lifestyle in a questionnaire family study: a comparison between highly cooperative and less cooperative families. Twin Research and Human Genetics 10, 348–353.CrossRefGoogle Scholar
Distel, MA, Trull, TJ, Boomsma, DI (2009 a). The genetic epidemiology of borderline personality disorder. In Borderline Personality Disorder: New Research (ed. Jackson, M. H. and Westbrook, L. F.), pp. 1–31. Nova Science Publishers, Inc.: Hauppauge, NY.Google Scholar
Distel, MA, Trull, TJ, Derom, CA, Thiery, EW, Grimmer, MA, Martin, NG, Willemsen, G, Boomsma, DI (2008 a). Heritability of borderline personality disorder features is similar across three countries. Psychological Medicine 38, 1219–1229.CrossRefGoogle ScholarPubMed
Distel, MA, Trull, TJ, Willemsen, G, Vink, JM, Derom, CA, Lynskey, MT, Martin, NG, Boomsma, DI (2009 b). The five factor model of personality and borderline personality disorder: a genetic analysis of comorbidity. Biological Psychiatry 66, 1131–1138.CrossRefGoogle ScholarPubMed
Helgeland, MI, Torgersen, S (2004). Developmental antecedents of borderline personality disorder. Comprehensive Psychiatry 45, 138–147.CrossRefGoogle ScholarPubMed
Horesh, N, Ratner, S, Laor, N, Toren, P (2008). A comparison of life events in adolescents with major depression, borderline personality disorder and matched controls: a pilot study. Psychopathology 41, 300–306.CrossRefGoogle ScholarPubMed
Johnson, JG, Cohen, P, Brown, J, Smailes, EM, Bernstein, DP (1999). Childhood maltreatment increases risk for personality disorders during early adulthood. Archives of General Psychiatry 56, 600–606.CrossRefGoogle ScholarPubMed
Jovev, M, Jackson, HJ (2006). The relationship of borderline personality disorder, life events and functioning in an Australian psychiatric sample. Journal of Personality Disorders 20, 205–217.CrossRefGoogle Scholar
Kendler, KS, Aggen, SH, Czajkowski, N, Roysamb, E, Tambs, K, Torgersen, S, Neale, MC, Reichborn-Kjennerud, T (2008). The structure of genetic and environmental risk factors for DSM-IV personality disorders: a multivariate twin study. Archives of General Psychiatry 65, 1438–1446.CrossRefGoogle ScholarPubMed
Kendler, KS, Eaves, LJ (1986). Models for the joint effect of genotype and environment on liability to psychiatric illness. American Journal of Psychiatry 143, 279–289.Google ScholarPubMed
Kendler, KS, Gardner, CO, Prescott, CA (2003). Personality and the experience of environmental adversity. Psychological Medicine 33, 1193–1202.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC, Maclean, CJ, Heath, AC, Eaves, LJ, Kessler, RC (1993). Smoking and major depression. A causal analysis. Archives of General Psychiatry 50, 36–43.CrossRefGoogle ScholarPubMed
Livesley, J (2008). Toward a genetically-informed model of borderline personality disorder. Journal of Personality Disorders 22, 42–71.CrossRefGoogle Scholar
McCrae, RR, Yang, J, Costa, PT, Dai, XY, Yao, SQ, Cai, TS, Gao, BL (2001). Personality profiles and the prediction of categorical personality disorders. Journal of Personality 69, 155–174.CrossRefGoogle ScholarPubMed
Middeldorp, CM, Cath, DC, Beem, AL, Willemsen, G, Boomsma, DI (2008). Life events, anxious depression and personality: a prospective and genetic study. Psychological Medicine 38, 1557–1565.CrossRefGoogle ScholarPubMed
Morey, LC (1991). The Personality Assessment Inventory: Professional Manual. Psychological Assessment Resources: Odessa, FL.Google Scholar
Muthén, LK, Muthén, BO (2005). Mplus User's Guide. Muthén & Muthén: Los Angeles, CA.Google Scholar
Neale, MC, Boker, SM, Xie, G, Maes, HH (2006). Mx: Statistical Modeling. VCU, Department of Psychiatry: Richmond, VA.Google Scholar
Paris, J (1997). Childhood trauma as an etiological factor in the personality disorders. Journal of Personality Disorders 11, 34–49.CrossRefGoogle ScholarPubMed
Plomin, R, Defries, JC, Loehlin, JC (1977). Genotype-environment interaction and correlation in analysis of human behavior. Psychological Bulletin 84, 309–322.CrossRefGoogle ScholarPubMed
Posthuma, D, Beem, AL, de Geus, EJC, van Baal, GCM, von Hjelmborg, JB, Lachine, I, Boomsma, DI (2003). Theory and practice in quantitative genetics. Twin Research 6, 361–376.CrossRefGoogle ScholarPubMed
Purcell, S (2002). Variance components models for gene-environment interaction in twin analysis. Twin Research 5, 554–571.CrossRefGoogle ScholarPubMed
Risch, N, Herrell, R, Lehner, T, Liang, KY, Eaves, L, Hoh, J, Griem, A, Kovacs, M, Ott, J, Merikangas, KR (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression a meta-analysis. Journal of the American Medical Association 301, 2462–2471.CrossRefGoogle ScholarPubMed
Rutter, M (2007). Gene-environment interdependence. Developmental Science 10, 12–18.CrossRefGoogle ScholarPubMed
Silk, KR, Lee, S, Hill, EM, Lohr, NE (1995). Borderline personality disorder symptoms and severity of sexual abuse. American Journal of Psychiatry 152, 1059–1064.Google ScholarPubMed
Terracciano, A, Tanaka, T, Sutin, AR, Deiana, B, Balaci, L, Sanna, S, Olla, N, Maschio, A, Uda, M, Ferrucci, L, Schlessinger, D, Costa, PT (2010). BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 35, 1083–1089.CrossRefGoogle ScholarPubMed
Torgersen, S, Czajkowski, N, Jacobson, K, Reichborn-Kjennerud, T, Roysamb, E, Neale, MC, Kendler, KS (2008). Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: a multivariate study. Psychological Medicine 38, 1617–1625.CrossRefGoogle Scholar
Van der Velden, PG, Van der Burg, S, Steinmetz, CHD, Van den Bout, J (1992). Victims of Bank Robberies [in Dutch]. Bohn Stafleu Van Loghum: Houten, The Netherlands.Google Scholar
Wagner, S, Baskaya, O, Dahmen, N, Lieb, K, Tadic, A (2010). Modulatory role of the brain-derived neurotrophic factor Val(66)Met polymorphism on the effects of serious life events on impulsive aggression in borderline personality disorder. Genes, Brain, and Behavior 9, 97–102.CrossRefGoogle ScholarPubMed
Wagner, S, Baskaya, O, Lieb, K, Dahmen, N, Tadic, A (2009). The 5-HTTLPR polymorphism modulates the association of serious life events (SLE) and impulsivity in patients with borderline personality disorder. Journal of Psychiatric Research 43, 1067–1072.CrossRefGoogle ScholarPubMed
Zanarini, MC, Williams, AA, Lewis, RE, Reich, RB, Vera, SC, Marino, MF, Levin, A, Yong, L, Frankenburg, FR (1997). Reported pathological childhood experiences associated with the development of borderline personality disorder. American Journal of Psychiatry 154, 1101–1106.Google ScholarPubMed