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HLA antigens and affective disorder: a family case report

Published online by Cambridge University Press:  09 July 2009

George Stein ,
Jeremy Holmes ,
John W. Bradford  and
Leslie Kennedy
George Stein*
Affiliation:
Maudsley Hospital, London, Tissue Typing Laboratories, Guy's Hospital, London
Jeremy Holmes
Affiliation:
Maudsley Hospital, London, Tissue Typing Laboratories, Guy's Hospital, London
John W. Bradford
Affiliation:
Maudsley Hospital, London, Tissue Typing Laboratories, Guy's Hospital, London
Leslie Kennedy
Affiliation:
Maudsley Hospital, London, Tissue Typing Laboratories, Guy's Hospital, London
*
1Address for correspondence: Dr George S. Stein, The Maudsley Hospital, Denmark Hill, London SE5 8AZ.
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Synopsis

A family of 6 affectively ill siblings is described. Two suffered from bipolar illnesses, 2 from recurrent unipolar illness, and the remainder showed alcoholism, depression and schizo-affective disorder. HLA typing revealed that all the tested members shared the antigens A3 and B7. Because only ill members were available for testing, there was insufficient information in the family to draw any definite conclusion as to whether these antigens were linked to the illness. However, the observation is of some interest in the light of other recent reports which have suggested that these 2 antigens are associated with affective disorder.

Type
Research Article
Information
Psychological Medicine , Volume 10 , Issue 4 , November 1980 , pp. 677 - 681
Copyright
Copyright © Cambridge University Press 1980

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References

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