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Haemoglobin A1c, fasting glucose and future risk of elevated depressive symptoms over 2 years of follow-up in the English Longitudinal Study of Ageing

Published online by Cambridge University Press:  02 February 2011

M. Hamer ,
G. D. Batty  and
M. Kivimaki
M. Hamer*
Affiliation:
Department of Epidemiology and Public Health, University College London, London, UK
G. D. Batty
Affiliation:
Department of Epidemiology and Public Health, University College London, London, UK Medical Research Council Social and Public Health Sciences Unit, Glasgow, UK Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK
M. Kivimaki
Affiliation:
Department of Epidemiology and Public Health, University College London, London, UK
*
*Address for correspondence: M. Hamer, Ph.D., Department of Epidemiology and Public Health, 1–19 Torrington Place, University College London, London WC1E 6BT, UK. (Email: [email protected])
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Abstract

Background

The cross-sectional association between impaired glucose/diabetes and depression is inconsistent. We examined the longitudinal associations between diabetes, indicators of glucose metabolism and depressive symptoms over 2 years of follow-up.

Method

Participants were 4338 men and women from the English Longitudinal Study of Ageing, a prospective study of community-dwelling older adults [aged 62.9 (s.d.=9.0) years, 45.2% men]. Depressive symptoms were assessed at baseline and after 2 years of follow-up using the eight-item Centre of Epidemiological Studies – Depression (CES-D) scale. Glycated haemoglobin (HbA1c) levels, fasting glucose and other biological and behavioural risk factors were also assessed at baseline.

Results

Approximately 11.5% of the sample were categorized with elevated depressive symptoms at follow-up (a score ⩾4 on the CES-D). There was an association between HbA1c and depressive symptoms at follow-up [per unit increase, odds ratio (OR) 1.17, 95% confidence interval (CI) 1.03–1.33] after adjustment for age and baseline CES-D. Cross-sectionally, the probability of depressive symptoms increased with increasing HbA1c levels until the value of 8.0% after which there was a plateau [p(curve)=0.03]. Compared with those with normal fasting glucose, participants with diabetes (confirmed through self-report or elevated fasting blood glucose) at baseline had an elevated risk of depressive symptoms at follow-up (OR 1.52, 95% CI 1.01–2.30) after adjusting for depressive symptoms at baseline, behavioural and sociodemographic variables, adiposity and inflammation.

Conclusions

These data suggest that poor glucose metabolism and diabetes are risk factors for future depression in older adults. There was no evidence of a U-shaped association.

Keywords

Ageingdepressive symptomsdiabeteshaemoglobin A1cpsychobiology
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 9 , September 2011 , pp. 1889 - 1896
Copyright
Copyright © Cambridge University Press 2011

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References

Aarts, S, van den Akker, M, van Boxtel, MP, Jolles, J, Winkens, B, Metsemakers, JF (2009). Diabetes mellitus type II as a risk factor for depression: a lower than expected risk in a general practice setting. European Journal of Epidemiology 24, 641–648.CrossRefGoogle Scholar
Adriaanse, MC, Dekker, JM, Heine, RJ, Snoek, FJ, Beekman, AJ, Stehouwer, CD, Bouter, LM, Nijpels, G, Pouwer, F (2008). Symptoms of depression in people with impaired glucose metabolism or type 2 diabetes mellitus: The Hoorn Study. Diabetic Medicine 25, 843–849.CrossRefGoogle ScholarPubMed
Ali, S, Stone, MA, Peters, JL, Davies, MJ, Khunti, K (2006). The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabetic Medicine 23, 1165–1173.CrossRefGoogle ScholarPubMed
American Diabetes Association (2008). Standards of medical care in diabetes – 2008. Diabetes Care 31 (Suppl. 1), S12–S54.CrossRefGoogle Scholar
Aujla, N, Abrams, KR, Davies, MJ, Taub, N, Skinner, TC, Khunti, K (2009). The prevalence of depression in white-European and South-Asian people with impaired glucose regulation and screen-detected type 2 diabetes mellitus. PLoS One 4, e7755.CrossRefGoogle ScholarPubMed
Chida, Y, Hamer, M (2008). An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies. Diabetologia 51, 2168–2178.CrossRefGoogle ScholarPubMed
Colman, I, Ploubidis, GB, Wadsworth, ME, Jones, PB, Croudace, TJ (2007). A longitudinal typology of symptoms of depression and anxiety over the life course. Biological Psychiatry 62, 1265–1271.CrossRefGoogle ScholarPubMed
de Lauzon-Guillain, B, Balkau, B, Charles, MA, Romieu, I, Boutron-Ruault, MC, Clavel-Chapelon, F (2010). Birth weight, body silhouette over the life course, and incident diabetes in 91 453 middle-aged women from the French Etude Epidemiologique de Femmes de la Mutuelle Generale de l'Education Nationale (E3N) Cohort. Diabetes Care 33, 298–303.CrossRefGoogle Scholar
Demakakos, P, Pierce, MB, Hardy, R (2010). Depressive symptoms and risk of type 2 diabetes in a national sample of middle-aged and older adults: the English Longitudinal Study of Aging. Diabetes Care 33, 792–797.CrossRefGoogle Scholar
Economic and Social Data Service (ESDS) (2008). English Longitudinal Study of Ageing: Wave 0 (1998, 1999 and 2001) and Waves 1–4 (2002–2009) (http://www.data-archive.ac.uk/findingData/snDescription.asp?sn=5050). Accessed 21 August 2008.Google Scholar
Fisher, L, Mullan, JT, Arean, P, Glasgow, RE, Hessler, D, Masharani, U (2010). Diabetes distress but not clinical depression or depressive symptoms is associated with glycemic control in both cross-sectional and longitudinal analyses. Diabetes Care 33, 23–28.CrossRefGoogle ScholarPubMed
Gale, CR, Kivimaki, M, Lawlor, DA, Carroll, D, Phillips, AC, Batty, GD (2010). Fasting glucose, diagnosis of type 2 diabetes, and depression: The Vietnam Experience Study. Biological Psychiatry 67, 189–192.CrossRefGoogle ScholarPubMed
Georgiades, A, Zucker, N, Friedman, KE, Mosunic, CJ, Applegate, K, Lane, JD, Feinglos, MN, Surwit, RS (2007). Changes in depressive symptoms and glycemic control in diabetes mellitus. Psychosomatic Medicine 69, 235–241.CrossRefGoogle ScholarPubMed
Golden, SH, Lazo, M, Carnethon, M, Bertoni, AG, Schreiner, PJ, Diez Roux, AV, Lee, HB, Lyketsos, C (2008). Examining a bidirectional association between depressive symptoms and diabetes. JAMA 299, 2751–2759.CrossRefGoogle ScholarPubMed
Graig, R, Deverill, C, Pickering, K (2006). Quality control of blood, saliva and urine analytes. In Health Survey for England 2004, Methodology and Documentation, vol. 2(ed. Spronston, K. and Mindell, J.), pp. 34–41. The Information Centre: London.Google Scholar
Holt, RI, Phillips, DI, Jameson, KA, Cooper, C, Dennison, EM, Peveler, RC; Hertfordshire Cohort Study Group (2009). The relationship between depression and diabetes mellitus: findings from the Hertfordshire Cohort Study. Diabetic Medicine 26, 641–648.CrossRefGoogle ScholarPubMed
Icks, A, Kruse, J, Dragano, N, Broecker-Preuss, M, Slomiany, U, Mann, K, Jöckel, KH, Erbel, R, Giani, G, Moebus, S; Heinz Nixdorf Recall Study Investigator Group (2008). Are symptoms of depression more common in diabetes? Results from the Heinz Nixdorf Recall study. Diabetic Medicine 25, 1330–1336.CrossRefGoogle ScholarPubMed
International Expert Committee (2009). International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care 32, 1327–1334.CrossRefGoogle Scholar
Kivimäki, M, Tabak, AG, Batty, GD, Singh-Manoux, A, Jokela, M, Akbaraly, TN, Witte, DR, Brunner, EJ, Marmot, MG, Lawlor, DA (2009). Hyperglycemia, type 2 diabetes, and depressive symptoms: the British Whitehall II study. Diabetes Care 32, 1867–1869.CrossRefGoogle ScholarPubMed
Knol, MJ, Heerdink, ER, Egberts, AC, Geerlings, MI, Gorter, KJ, Numans, ME, Grobbee, DE, Klungel, OH, Burger, H (2007). Depressive symptoms in subjects with diagnosed and undiagnosed type 2 diabetes. Psychosomatic Medicine 69, 300–305.CrossRefGoogle ScholarPubMed
Mezuk, B, Eaton, WW, Albrecht, S, Golden, SH (2008). Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care 31, 2383–2390.CrossRefGoogle ScholarPubMed
Pan, A, Lucas, M, Sun, Q, van Dam, RM, Franco, OH, Manson, JE, Willett, WC, Ascherio, A, Hu, FB (2010). Bidirectional association between depression and type 2 diabetes mellitus in women. Archives of Internal Medicine 170, 1884–1891.CrossRefGoogle ScholarPubMed
Rhee, MK, Musselman, D, Ziemer, DC, Vaccarino, V, Kolm, P, Weintraub, WS, Caudle, JM, Varughese, RM, Irving, JM, Phillips, LS (2008). Unrecognized glucose intolerance is not associated with depression. Screening for Impaired Glucose Tolerance study 3 (SIGT 3). Diabetic Medicine 25, 1361–1365.CrossRefGoogle Scholar
Shelton, N (2008). Diabetes. In Health Survey for England 2006. Cardiovascular Disease and Risk Factors in Adults(ed. Craig, R. and Mindell, J.), pp. 63–84. The Information Centre: London.Google Scholar
Steffick, DE (2000). Documentation of affective functioning measures in the Health and Retirement Study (HRS/AHEAD Documentation. Report DR-005). Survey Research Center, University of Michigan: Ann Arbor, MI (http://hrsonline.isr.umich.edu/docs/userg/dr-005.pdf). Accessed 1 August 2008.CrossRefGoogle Scholar
Thomas, C, Hyppönen, E, Power, C (2008). Obesity and type 2 diabetes risk in mid adult life: the role of childhood adversity. Pediatrics 121, e1240–e1249.CrossRefGoogle Scholar
Wancata, J, Alexandrowicz, R, Marquart, B, Weiss, M, Friedrich, F (2006). The criterion validity of the Geriatric Depression Scale: a systematic review. Acta Psychiatrica Scandinavica 114, 398–410.CrossRefGoogle ScholarPubMed
Yau, PL, Javier, DC, Ryan, CM, Tsui, WH, Ardekani, BA, Ten, S, Convit, A (2010). Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus. Diabetologia 53, 2298–2306.CrossRefGoogle ScholarPubMed