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Genetic factors in the response to neuroleptics in schizophrenia: a psychopharmacogenetic study

Published online by Cambridge University Press:  09 July 2009

Joe Galdi ,
Ronald O. Rieder ,
David Silber  and
Roland R. Bonato
Joe Galdi*
Affiliation:
Biometric Laboratory, George Washington University, Bethesda, Maryland, USA
Ronald O. Rieder
Affiliation:
Biometric Laboratory, George Washington University, Bethesda, Maryland, USA
David Silber
Affiliation:
Biometric Laboratory, George Washington University, Bethesda, Maryland, USA
Roland R. Bonato
Affiliation:
Biometric Laboratory, George Washington University, Bethesda, Maryland, USA
*
1Address for correspondence: Dr Joe Galdi, Department of Psychiatry, University of Cincinnati College of Medicine, Rm 7303, MSB, Cincinnati, OH 45267, USA.
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Synopsis

A psychopharmacogenetic strategy was used to investigate a genetic heterogeneity model of schizophrenia. This model consisted of various genetic subtypes represented by patients classified hypothetically according to the types and genealogical (Mendelian) patterns of illnesses in first-degree relatives. The effect of neuroleptics on these subtypes (drug x genetic subtype interactions) were tested for evidence of post-treatment responses which discriminated between them. The findings revealed that schizophrenics who had depressed relatives tended to exhibit (1) depression and more severe pseudoparkinsonism irrespective of types of neuroleptics, and (2) greater remission of paranoid-hostility symptoms when treated with neuroleptics of the aliphatic-piperadine type. Schizophrenics who had schizophrenic relatives failed to show these responses.

Interpretation of these findings emphasized the recognition of these responses as arising from neuroleptic-induced alterations of defective neurologic-neurochemical systems underlying this subtype and as ‘pharmacogenetic criteria’ by which it can be discriminated.

Type
Research Article
Information
Psychological Medicine , Volume 11 , Issue 4 , November 1981 , pp. 713 - 728
Copyright
Copyright © Cambridge University Press 1981

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