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Genetic and environmental influences on obsessional traits and symptoms

Published online by Cambridge University Press:  09 July 2009

C. A. Clifford
Affiliation:
Departments of Psychology and Psychiatry, Institute of Psychiatry, London
R. M. Murray*
Affiliation:
Departments of Psychology and Psychiatry, Institute of Psychiatry, London
D. W. Fulker
Affiliation:
Departments of Psychology and Psychiatry, Institute of Psychiatry, London
*
1Address for correspondence: Dr R. M. Murray, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SES 8AF.

Synopsis

A biometrical genetic analysis was carried out on the response of 419 pairs of twins to the 42-item version of the Leyton Obsessional Inventory. Just under half the variation in both the Obsessional Trait and Symptom Scales was due to heredity. Multivariate analysis revealed a genetic effect on the development of obsessional personality and also the transmission of a general tendency predisposing to neurotic breakdown. Although the influence of heredity was outweighed by that of the environment, the latter effect showed an absence of general factors and, in particular, of any noticeable effect from the common home environment.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1984

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References

Black, A. (1974). The natural history of obsessional states. In Obsessional States (ed. Beech, H. R.), pp. 2054. Methuen: London.Google Scholar
Brown, F. W. (1942). Heredity in the psychoneuroses. Proceedings of the Royal Society of Medicine 35, 785790.CrossRefGoogle ScholarPubMed
Carey, G. (1978). A clinical-genetic study of obsessional and phobic states. Ph.D. Thesis: University of Minnesota.Google Scholar
Carey, G. & Gottesman, I. I. (1981). Defining cases by genetic criteria. In What is a Case? (ed. Wing, J. K., Bebbington, P. and Robins, L. W.), pp. 2941. Grant McIntyre: London.Google Scholar
CERN (1974). Minuit: a Package of Programmes to Minimize a Function of a Variable. CERN Data Handling Division: Geneva.Google Scholar
Cooper, J. E. (1970). The Leyton Obsessional Inventory. Psychological Medicine 1, 4864.CrossRefGoogle ScholarPubMed
Cooper, J. E. & Kelleher, M. Y. (1973). The Leyton Obsessional Inventory: a principal components analysis on normal subjects. Psychological Medicine 3, 204208.CrossRefGoogle ScholarPubMed
Cooper, J. E., Murray, A. M. & Smith, A. (1984). Unpublished observations.Google Scholar
Eaves, L. J. & Eysenck, H. J. (1974). Genetics and the development of social attitudes. Nature 249, 288289.CrossRefGoogle ScholarPubMed
Eysenck, H. J. & Eysenck, S. B. G. (1964). Manual of the Eysenck Personality Inventory. University of London.Google Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1975). Manual of the Eysenck Personality Questionnaire. Hodder & Stoughton: London.Google Scholar
Fulker, D. W. (1979). Some implications of biometrical genetical analysis for psychological research. In Theoretical Advances in Behaviour Genetics (ed. Royce, J. R. and Mos, L. P.), pp. 337379. Sijthoff and Noordhoss: Leiden.CrossRefGoogle Scholar
Fulker, D. W., Zuckerman, M. & Eysenck, S. B. G. (1980). A genetic and environmental analysis of sensation seeking. Journal of Research in Personality 14, 261281.CrossRefGoogle Scholar
Gossop, M. (1981). Theories of Neurosis. Springer-Verlag: Berlin.CrossRefGoogle Scholar
Gottesman, I. I. (1962). Differential inheritance of the psychoneuroses. Eugenics Quarterly 9, 223227.CrossRefGoogle ScholarPubMed
Gottesman, I. I. (1963). Heritability of personality: a demonstration. Psychological Monographs 77, 121.CrossRefGoogle ScholarPubMed
Hoaken, P. C. S. & Schnurr, R. (1980). Genetic factors in obsessive-compulsive neurosis? Canadian Journal of Psychiatry 25, 167172.CrossRefGoogle ScholarPubMed
Inouye, E. (1965). Similar and dissimilar manifestations of obsessive-compulsive neurosis in monozygotic twins. American Journal of Psychiatry 121, 11711175.CrossRefGoogle ScholarPubMed
Jinks, J. L. & Fulker, D. W. (1970). Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of human behaviour. Psychological Bulletin 73, 311349.CrossRefGoogle Scholar
Kasriel, J. & Eaves, L. (1976). The zygosity of twins: further evidence on the agreement between diagnosis by blood groups and written questionnaires. Journal of Biological Science 8, 263266.Google ScholarPubMed
Kendell, R. E. & DiScipio, W. J. (1970). Obsessional symptoms and obsessional personality traits in patients with depressive illness. Psychological Medicine 1, 6572.CrossRefGoogle Scholar
Kringlen, E. (1965). Obsessional neurotics: a long-term follow-up. British Journal of Psychiatry 111, 709722.CrossRefGoogle ScholarPubMed
Lewis, A. (1935). Problems of obsessional illness. Proceedings of the Royal Society of Medicine 29, 325336.CrossRefGoogle Scholar
Loehlin, J. C. & Nichols, R. C. (1976). Heredity, Environment and Personality. University of Texas: Austin.Google Scholar
Luxenburger, H. (1930). Heredität und Familientypus der Zwangsneurotiker. Archiv für Psychiatrie 91, 590594.Google Scholar
Marks, I. M., Crowe, M., Drewe, E., Young, J. & Dewhurst, W. G. (1969). Obsessive-compulsive neurosis in identical twins. British Journal of Psychiatry 115, 991998.CrossRefGoogle ScholarPubMed
McGuffin, P. & Mawson, D. (1980). Obsessive compulsive neurosis: two concordant twin pairs. British Journal of Psychiatry 137, 285287.CrossRefGoogle Scholar
Murray, R. M., Cooper, J. E. & Smith, A. (1979). The Leyton Obsessional Inventory: an analysis of the responses of 73 obsessional patients. Psychological Medicine 9, 305311.CrossRefGoogle ScholarPubMed
Murray, R. M., Clifford, C., Fulker, D. W. & Smith, A. (1984). Does heredity contribute to obsessional traits and symptoms? In Genetic Epidemiology (ed. Tsuang, M.). Psychological Monograph Series. Neale Watson: New York (in the press).Google Scholar
Parker, N. (1964). Twins: a psychiatric study of a neurotic group. Medical Journal of Australia ii, 735742.CrossRefGoogle Scholar
Rachman, S. J. & Hodgson, R. J. (1980). Obsessions and Compulsions. Prentice-Hall: New Jersey.Google Scholar
Rosenberg, C. M. (1967). Familial aspects of obsessional neurosis. British Journal of Psychiatry 113, 405413.CrossRefGoogle ScholarPubMed
Rüdin, E. (1953). Ein Beitrag zur Frage der Zwangskrankheit insbesondere ihrer hereditären Beziehungen. Archiv für Psychiatrie und Zeitschrift für Neurologie 191, 1454.CrossRefGoogle Scholar
Shields, J. (1978). The genetics of neurosis: facts or fiction. Paper read at a Symposium in Stockholm.Google Scholar
Slater, E. (1943). The neurotic constitution: a statistical study of two thousand soldiers. Journal of Neurological Psychiatry 6, 116.CrossRefGoogle Scholar
Snowdon, J. A. (1980). A comparison of written and postbox forms of the Leyton Obsessional Inventory. Psychological Medicine 10, 165170.CrossRefGoogle ScholarPubMed
Tienari, P. (1963). Psychiatric illnesses in identical twins. Acta Psychiatrica Scandinavica Suppl. 171.Google Scholar
Vandenberg, S. G. (1967). Hereditary factors in normal personality traits. In Recent Advances in Biological Psychiatry, Vol. 9 (ed. Wortis, J.), pp. 65104. Plenum Press: New York.CrossRefGoogle Scholar
Woodruff, R. & Pitts, F. N. (1964). Monozygotic twins with obsessional illness. American Journal of Psychiatry 120, 10751080.CrossRefGoogle ScholarPubMed
Young, J. P. R., Fenton, G. W. & Lader, M. H. (1971). The inheritance of neurotic traits: a twin study of the Middlesex Hospital Questionnaire. British Journal of Psychiatry 119, 393398.CrossRefGoogle ScholarPubMed