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Evoked potential correlates of information processing in psychiatric patients1

Published online by Cambridge University Press:  09 July 2009

Robert A. Levit ,
Samuel Sutton  and
Joseph Zubin
Robert A. Levit
Affiliation:
Biometrics Research, New York State Department of Mental Hygiene
Samuel Sutton
Affiliation:
Biometrics Research, New York State Department of Mental Hygiene
Joseph Zubin
Affiliation:
Biometrics Research, New York State Department of Mental Hygiene
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Synopsis

Visual and auditory evoked potentials were recorded from the scalp under conditions of uncertainty versus certainty, correctness versus incorrectness of pretrial guess, and shift versus repetition of the sensory modality of the stimulus. Schizophrenic patients, psychotic depressive patients, and normal controls were matched for age, sex, race, and socioeconomic status and educational level. The two patient groups were matched for medication (chlorpromazine) dosage level. Under all conditions normals exhibited the largest N1-P3 evoked potential amplitudes, while depressives exhibited the next largest and schizophrenics the smallest. All three groups had larger Ni-Pa amplitudes in the uncertain condition than in the certain condition. However, the effect of uncertainty was greatest in the normal group and least in the schizophrenic group. There were no significant interactions between group membership and guessing correctly and incorrectly. On the other hand, there was a significant interaction between group membership and modality shift. Depressives and normals tended to have larger N1-P3 amplitudes in the crossmodal condition, while schizophrenics tended to have larger amplitudes in the ipsimodal condition.

Type
Research Article
Information
Psychological Medicine , Volume 3 , Issue 4 , November 1973 , pp. 487 - 494
Copyright
Copyright © Cambridge University Press 1973

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References

REFERENCES

Bixler, E. O. Jr. (1970). The Visual Evoked Potential and Reaction Time in the Retardate. (Doctoral dissertation, University of New Mexico.) No. 71–9290. University Microfilms: Ann Arbor, Michigan.Google Scholar
Burdock, E. I., Sutton, S., and Zubin, J. (1958). Personality and psychopathology. Journal of Abnormal and Social Psychology, 56, 18–30.CrossRefGoogle ScholarPubMed
Callaway, E., Jones, R. T., and Donchin, E. (1970). Auditory evoked potential variability in schizophrenia. Electroencephalography and Clinical Neurophysiology, 29, 421–428.CrossRefGoogle ScholarPubMed
Callaway, E. III, Jones, R. T., and Layne, R. S. (1965). Evoked responses and segmental set of schizophrenia. Archives of General Psychiatry, 12, 83–89.CrossRefGoogle ScholarPubMed
Dureman, I., and Wilén, B. (1963). Effects of interstimulus interval and predictability of event structure on serial reaction time. Scandinavian Journal of Psychology, 4, 135–138.CrossRefGoogle Scholar
Friedman, D. (1971). Effects of Stimulus Uncertainty on the Pupillary Dilation Response and the Vertex Evoked Potential in Man. Unpublished doctoral dissertation, University of the City of New York.Google Scholar
Grice, G. R., and Hunter, J. J. (1964). Stimulus intensity effects depend upon the type of experimental design. Psychological Review 71, 247–256.CrossRefGoogle ScholarPubMed
Hannes, E. M. (1966). The Effect of Stimulus Uncertainty on Simple Response Time. (Doctoral dissertation, Columbia University.) No. 69–15, 557. University Microfilms: Ann Arbor, Michigan.Google Scholar
Hogan, D. D. (1971). Cortical response of retardates for AER audiometry. American Journal of Mental Deficiency, 75, 474–477.Google ScholarPubMed
Karlin, L., Martz, M. J., and Mondkoff, A. M. (1970). Motor performance and sensory-evoked potentials. Electroencephalography and Clinical Neurophysiology, 28, 307313.CrossRefGoogle ScholarPubMed
Kriegel, J., Sutton, S., and Kerr, J. (in press). Effect of modality shift on reaction time in schizophrenia. In Experimental Approaches to Psychopathology. Edited by Kietzman, M., Sutton, S., and Zubin, J.. Academic Press: New York.Google Scholar
Miller, R. G. J. (1966). Simultaneous Statistical Inference. McGraw-Hill: New York.Google Scholar
Mowrer, O. H. (1941). Preparatory set (expectancy)— Further evidence of its ‘central’ locus. Journal of Experimental Psychology, 28, 116–133.CrossRefGoogle Scholar
Rodin, E., Grisell, J., and Gottlieb, J. (1968). Some electrographic differences between chronic schizophrenic patients and normal subjects. In Recent Advances in Biological Psychiatry, Vol. 10, pp. 194–208. Edited by Wortis, J.. Plenum Press: New York.CrossRefGoogle Scholar
Rodin, E., Zacharopoulos, G., Beckett, P., and Frohman, C. (1964). Characteristics of visually evoked responses in normal subjects and schizophrenic patients. (Abstract.) Electroencephalography and Clinical Neurophysiology, 17, 458.Google Scholar
Saletu, B., Itil, T. M., and Saletu, M. (1971). Auditory evoked response, EEG, and thought process in schizophrenics. American Journal of Psychiatry, 128, 336–343.CrossRefGoogle ScholarPubMed
Shagass, C., and Straumanis, J. (1969). Evoked potentials and psychopathology. In Neurobiological Aspects of Psychopathology. Edited by Zubin, J. and Shagass, C.. Grune and Stratton: New York.Google Scholar
Spitzer, R. L., and Endicott, J. (1968a). Psychiatric Status Schedule—PSS. Interview schedule. Biometrics Research. New York State Department of Mental Hygiene: New York.Google Scholar
Spitzer, R. L., and Endicott, J. (1968b). Current and Past Psychopathology Scales-CAPPS. Interview schedule. Biometrics Research. New York State Department of Mental Hygiene: New York.Google Scholar
Sutton, S. (1969). The specification of psychological variables in an average evoked potential experiment. In Average Evoked Potentials: Methods, Results, and Evaluations. Edited by Donchin, E. and Lindsley, D. B.. pp. 237–297. NASA-SP-191 (N70–16876.) U.S. Government Printing Office: Washington, D.C.CrossRefGoogle Scholar
Sutton, S. (1973). Fact and artifact in the psychology of schizophrenia. In Psychopathology: Contributions from the Social, Behavioral, and Biological Sciences. Edited by Hammer, M., Salzinger, K., and Sutton, S.. Wiley: New York.Google Scholar
Sutton, S., Braren, M., Zubin, J., and John, E. R. (1965). Evoked-potential correlates of stimulus uncertainty. Science, 150, 1187–1188.CrossRefGoogle ScholarPubMed
Sutton, S., Tueting, P., Zubin, J., and John, E. R. (1967). Information delivery and the sensory evoked potential. Science, 155, 1436–1439.CrossRefGoogle ScholarPubMed
Tueting, P., Sutton, S., and Zubin, J. (1971). Quantitative evoked potential correlates of the probability of events. Psychophysiology, 7, 385–394.CrossRefGoogle Scholar
Zahn, T. P. (1970). Effects of reductions in uncertainty on reaction time in schizophrenic and normal subjects. Journal of Experimental Research in Personality, 4, 135–143.Google Scholar
Zubin, J., and Katz, M. M. (1966). Psychopharmacology and personality. International Journal of Psychiatry, 2, 640–675.Google ScholarPubMed
Zubin, J., and Sutton, S. (1970). Assessment of physiological, sensory, perceptual, psychomotor, and conceptual functioning in schizophrenic patients. Acta Psychiatrica Scandinavica, 46, Suppl. 219, 247–263.CrossRefGoogle Scholar