Hostname: page-component-5cf477f64f-rdph2 Total loading time: 0 Render date: 2025-04-08T08:29:40.502Z Has data issue: false hasContentIssue false
  • English
  • Français

Epileptic seizures induced by psychotropic drugs

Published online by Cambridge University Press:  09 July 2009

B. K. Toone  and
G. W. Fenton
B. K. Toone*
Affiliation:
Maudsley Hospital, London
G. W. Fenton
Affiliation:
Maudsley Hospital, London
*
1Address for correspondence: Dr B. K. Toone, The Maudsley Hospital, Denmark Hill, London SE5 8AZ.
Get access Rights & Permissions [Opens in a new window]

Synopsis

On the basis of information abstracted from case histories, 41 patients who had experienced epileptic seizures thought to be due either to treatment with psychiatric drugs or to withdrawal from sedative drugs were compared with a control group of patients. Those who had experienced seizures were more commonly first born and had a history of post-natal brain damage. During the week preceding the seizure there had been a marked increase in drug prescribing. The implications for drug management are discussed.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 2 , May 1977 , pp. 265 - 270
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Anton-Stephens, D. (1953). Preliminary observations on the psychiatric use of chlorpromazine. Journal of Mental Science 100, 543–557.CrossRefGoogle Scholar
Betts, T., Kalra, P., Cooper, R. & Jeavons, P. (1968). Epileptic fits as a probable side effect of amitriptyline. Lancet i, 390–392.CrossRefGoogle Scholar
Colver, T. & Kerridge, D. F. (1961). Birth order in epileptic children. Proceedings of the Royal Society of Medicine 54, 1015–1016.CrossRefGoogle ScholarPubMed
Cooper, J. E. (1965). Epilepsy in a longitudinal survey of 5000 children. British Medical Journal i, 1020–1022.CrossRefGoogle Scholar
Dallos, U. & Heathfield, K. (1969). Iatrogenic epilepsy due to antidepressant drugs. British Medical Journal iv, 80–82.CrossRefGoogle Scholar
Essig, C. & Fraser, H. (1958). Electroencephalographic changes in man during use and withdrawal of barbiturates in moderate dosage. Electroencephalography and Clinical Neurophysiology 10, 649–656.CrossRefGoogle ScholarPubMed
Hollister, L., Bennett, J., Kimbell, I., Savage, C. & Overall, J. (1963). Diazepam in newly admitted schizophrenics. Diseases of the Nervous System 24, 746–750.Google ScholarPubMed
Kurtzke, J. (1957). Seizures with promazine. A preliminary report. Journal of Nervous and Mental Disease 125, 119.CrossRefGoogle ScholarPubMed
Liddell, D. & Retterstøl, N. (1957). The occurrence of epileptic fits in leucotomized patients receiving chlorpromazine therapy. Journal of Neurology, Neurosurgery and Psychiatry 20, 105–107.CrossRefGoogle ScholarPubMed
Logothetis, J. (1967). Spontaneous epileptic seizures and electroencephalographic changes in the course of phenothiazone therapy. Neurology 17, 869–877.CrossRefGoogle Scholar
Nielsen, J. M. & Butler, F. O. (1948). Birth primary and idiopathic epilepsy. Bulletin of Los Angeles Neurological Society 13, 176–178.Google Scholar
Schlichter, W., Bristow, M., Schultz, S. & Henderson, A. (1956). Seizures occurring during intensive chlorpromazine therapy. Canadian Medical Association Journal 74, 364–366.Google Scholar