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A controlled evaluation of lithium prophylaxis in affective disorders

Published online by Cambridge University Press:  09 July 2009

R. L. Cundall ,
P. W. Brooks  and
L. G. Murray
R. L. Cundall
Affiliation:
From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh
P. W. Brooks
Affiliation:
From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh
L. G. Murray
Affiliation:
From the M.R.C. Brain Metabolism Unit3, Royal Edinburgh Hospital, Edinburgh
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Synopsis

In a double-blind crossover trial lithium carbonate was found to be significantly superior to placebo in the prophylaxis of manic-depressive (bipolar) psychosis. A striking feature was the high incidence of manic or hypomanic attacks in patients who relapsed on placebo. Patients participated in the trial with their full knowledge and consent.

Type
Preliminary communication
Information
Psychological Medicine , Volume 2 , Issue 3 , August 1972 , pp. 308 - 311
Copyright
Copyright © Cambridge University Press 1972

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References

REFERENCES

Baastrup, P. C., Poulsen, J. C., Schou, M., Thomsen, K., and Amdisen, A. (1970). Prophylactic lithium: double-blind discontinuation in manic-depressive and recurrentdepressive disorders. Lancet, 2, 326–330.CrossRefGoogle ScholarPubMed
Coppen, A., Noguera, R., Bailey, J., Burns, B. H., Swani, M. S., Hare, E. H., Gardner, R., and Maggs, R. (1971). Prophylactic lithium in affective disorders. Controlled trial. Lancet, 2, 275–279.CrossRefGoogle ScholarPubMed
Melia, P. I. (1970). Prophylactic lithium in recurrent-affective disorders: a four year study. Journal of the Irish Medical Association, 63, 353–357.Google ScholarPubMed
Perris, C. (1966). A study of bipolar (manic-depressive) and unipolar (recurrent depressive) psychoses. Acta Psychiatrica Scandinavica, Supplement 194 ad., 42.Google Scholar