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Cognitive functioning and symptomatology in chronic schizophrenia

Published online by Cambridge University Press:  09 July 2009

Hazel E. Nelson ,
Christos Pantelis ,
Kathryn Carruthers ,
Jeremy Speller ,
Sallie Baxendale  and
Thomas R. E. Barnes
Hazel E. Nelson*
Affiliation:
Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey
Christos Pantelis
Affiliation:
Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey
Kathryn Carruthers
Affiliation:
Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey
Jeremy Speller
Affiliation:
Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey
Sallie Baxendale
Affiliation:
Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey
Thomas R. E. Barnes
Affiliation:
Charing Cross and Westminster Medical School, Academic Unit, Horton Hospital, Epsom, Surrey
*
1Address for correspondence: Dr H. E. Nelson, Department of Psychology, Horton Hospital, Epsom, Surrey KT19 8PZ.
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Synopsis

Chronic schizophrenic patients in a long stay hospital were found to have low levels of intelligence (mean IQ of 80), which was attributed to the effects of substantial intellectual deterioration on below average pre-morbid levels of functioning. Patients with the lowest IQ scores had the least severe positive symptoms but symptomatology was not related to age or extent of intellectual decline. Speed of functioning was relatively more impaired than level of intellectual functioning, with cognitive speed being more affected than motor speed. The severity of negative but not positive symptoms was significantly related to the severity of bradyphrenia (cognitive slowing), a result which would be consistent with the notion of a subcortical pathology in patients with Type II schizophrenia.

Type
Original Articles
Information
Psychological Medicine , Volume 20 , Issue 2 , May 1990 , pp. 357 - 365
Copyright
Copyright © Cambridge University Press 1990

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References

Adams, K. M., Jacisin, J. J., Brown, G. G., Boulos, R. S. & Silk, S. D. (1984). Neurobehavioural deficit and computed tomographic abnormalities in three samples of schizophrenic patients. Perceptual and Motor Skills 59, 115–119.Google Scholar
Addington, J. (1987). Cognitive functioning and positive and negative symptoms in schizophrenia. Ph.D. thesis, University of Calgary. Alberta.Google Scholar
Albert, M. L., Feldman, R. G. & Willis, A. L. (1974). The ‘subcortical dementia’ of progressive supranuclear palsy. Journal of Neurology, Neurosurgery and Psychiatry 37, 121–130.Google Scholar
Babcock, H. (1930). An experiment in the measurement of mental deterioration. Archives of Psychology 18 (no. 117).Google Scholar
Babcock, H. (1933). Dementia Praecox: A Psychological Study. Science Press: New York.CrossRefGoogle Scholar
Babcock, H. (1941). Time and the Mind. Sci-Art Publishers: New York.Google Scholar
Barnes, T. R. E. (1988). Tardive dyskinesia: risk factors, pathophysiology and treatment. In Recent Advances in Clinical Psychiatry No. 6. (ed. Granville-Grossman, K.), pp. 185–205. Churchill Livingstone: London.Google Scholar
Benson, D. F. (1983). Subcortical dementia: a clinical approach. In The Dementias (ed. Mayeux, R. & Rosen, W.), pp. 185–194. Raven Press: New York.Google Scholar
Bilder, R. M. (1985). Subtyping in chronic shizophrenia: clinical, neuropsychological and structural indices of deterioration. University Microfilms, Ann Arbor, MI.Google Scholar
Bilder, R. M., Degreef, G., Pandurangi, A. K., Rieder, R. O., Sackheim, H. A. & Hukherjee, S. (1988). Neuropsychological deterioration and CT scan findings in chronic schizophrenia. Schizophrenia Research 1, 37–45.CrossRefGoogle ScholarPubMed
Chelune, G. J., Heaton, R. K., Lehman, R. A. & Robinson, S. (1979). Level versus pattern of neuropsychological performance among schizophrenic and diffusely brain damaged patients. Journal of Consulting and Clinical Psychology 47, 155–163.CrossRefGoogle ScholarPubMed
Cohen, B. D. (1956). Motivation and performance in schizophrenia. Journal of Abnormal and Social Psychology 52, 186–190.CrossRefGoogle ScholarPubMed
Coughlan, A. & Hollows, S. (1983). Adult Memory and Information Processing Battery. Coughlan, St. James Infirmary: Leeds.Google Scholar
Crawford, J. R. (1989). Estimation of premorbid intelligence: a review of recent developments. In Developments in Clinical and Experimental Neuropsychology (ed. Crawford, J. R. and Parker, D. M.) pp. 55–74. Plenum: London.CrossRefGoogle Scholar
Crawford, J. R., Stewart, L. E., Cochrane, R. H. B., Foulds, J. A., Besson, J. A. O. & Parker, D. M. (1989). Estimating premorbid IQ from demographic variables: regression equations derived from a UK sample. British Journal of Clinical Psychology 28, 275–278.CrossRefGoogle ScholarPubMed
Crow, T. J. (1980). Molecular pathology and schizophrenia: more than one disease process? British Medical Journal 280, 66–68.Google Scholar
Cummings, J. L. (1986). Subcortical dementia: neuropsychology, neuropsychiatry, and pathophysiology. British Journal of Psychiatry 149, 682–697.CrossRefGoogle ScholarPubMed
Dalby, J. T. & Williams, R. (1986). Preserved reading and spelling ability in psychiatric disorders. Psychological Medicine 16, 171–175.Google Scholar
Donnelly, E. F., Weinberger, D. R., Waldman, I. N. & Wyatt, R. J. (1980). Cognitive impairment associated with morphological brain abnormalities on computed tomography in chronic schizophrenic patients. Journal of Nervous and Mental Diseases 48, 305–308.CrossRefGoogle Scholar
Eysenck, H. J., Granger, G. W. & Brengelmann, J. C. (1957). Perceptual Processes and Mental Illness. Maudsley monograph, 2. Institute of Psychiatry: London.Google Scholar
Golden, C. J., Moses, J. A., Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. B. & Berger, P. A. (1980). Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics. Archives of General Psychiatry 37, 619–623.CrossRefGoogle ScholarPubMed
Goldstein, G. (1986). The neuropsychology of schizophrenia. In Neuropsychological Assessment of Neuropsychiatric Disorders, (ed. Grant, I. and Adams, K.), pp. 147–171. Oxford University Press.Google Scholar
Harris, A. & Metcalfe, M. (1956). Inappropriate affect. Journal of Neurology and Psychiatry 19, 308–313.Google Scholar
Haug, J. O. (1962). Pneumoencephalographic studies in mental disease. Acta Psychiatrica Scandinavia 38, 1–115.Google ScholarPubMed
Heaton, R. K. & Crowley, T. J. (1981). Effects of psychiatric disorders and their somatic treatments on neuropsychological test results. In Handbook of Clinical Neuropsychology (ed. Filskov, S. B. and Boll, T. J.), pp. 481–525. Wiley-Interscience: New York.Google Scholar
Heaton-Ward, A. (1977). Psychosis in mental handicap. The 10th Blake Marsh lecture delivered before the Royal College of Psychiatrists, 2 February 1976. British Journal of Psychiatry 130, 525–533.CrossRefGoogle Scholar
Hemsley, D. R. (1978). Limitations of operant procedures in the modification of schizophrenic functioning: the possible relevance of studies of cognitive disturbance. Behaviour Analysis and Modification 3, 165–173.Google Scholar
Hemsley, D. R. (1982). Cognitive impairment in schizophrenia. In The Pathology and Psychology of Cognition (ed. Burton, A.), pp. 169–203. Methuen: London.Google Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., Husband, J. & Kreel, L. (1976). Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet ii, 924–926.Google Scholar
Johnstone, E. C., Owens, D. G. C., Gold, A., Crow, T. J. & MacMillan, J. E. (1981). Institutionalisation and the defects of schizophrenia. British Journal of Psychiatry 139, 195–203.Google Scholar
Kingsley, D. & Trimble, M. (1978). Cerebral ventricular size in chronic schizophrenia. Lancet i, 278–279.Google Scholar
Kleinman, J. E., Casanova, M. F. & Jaskiw, G. E. (1988). The neuropathology of schizophrenia. Schizophrenia Bulletin 14, 209–216.CrossRefGoogle ScholarPubMed
Krawiecka, M., Goldberg, D. & Vaughn, M. (1977). A standardized psychiatric assessment scale for rating chronic psychotic patients. Acta Psychiatrica Scandinavia 55, 299–308.CrossRefGoogle ScholarPubMed
Laplane, D., Baulac, M., Widlocher, D. & Dubois, B. (1984). Pure psychic akinesia with bilateral lesions of basal ganglia. Journal of Neurology, Neurosurgery and Psychiatry 47, 377–385.CrossRefGoogle ScholarPubMed
Lidsky, T. I., Weinhold, P. M. & Levine, F. M. (1979). Implications of basal ganglionic dysfunction for schizophrenia. Biological Psychiatry 14, 3–12.Google Scholar
Lund, J. (1985). Prevalence of psychiatric morbidity in mentally retarded adults. Acta Psychiatrica Scandinavica 72, 563–570.CrossRefGoogle ScholarPubMed
McFie, J. (1975). Assessment of Organic Intellectual Impairment. Academic Press: New York.Google Scholar
Matthews, C. G. & Booker, H. E. (1972). Pneumoencephalographic measurements and neuropsychological test performance in human adults. Cortex 8, 69–92.CrossRefGoogle ScholarPubMed
Mayer-Gross, W., Slater, E. & Roth, M. (1977). Clinical Psychiatry (3rd edn). Bailliere Tindall: London.Google Scholar
Mettler, F. A. (1955). Perceptual capacity, functions of the striatum and schizophrenia. Psychiatric Quarterly 89.Google Scholar
Nelson, H. E. (1982). The National Adult Test. NFER-Nelson: Windsor.Google Scholar
Pantelis, C., Barnes, T. R. E. & Nelson, H. E. (1989 a). A pilot study of subcortical dementia in schizophrenia. Schizophrenia Research 2, 69.CrossRefGoogle Scholar
Pantelis, C., Barnes, T. R. E. & Nelson, H. E. (1989 b). Is the concept of subcortical dementia relevant to schizophrenia? (Submitted for publication.)CrossRefGoogle Scholar
Reid, A. H. (1983). Psychiatry of mental handicap: a review. Journal of Royal Society of Medicine 76, 587–592.Google Scholar
Reveley, A. M., Clifford, C. A. & Murray, R. M. (1982). Cerebral ventricular size in twins discordant for schizophrenia. Lancet ii, 540–541.CrossRefGoogle Scholar
Rogers, D. (1986). Bradyphrenia in parkinsonism: a historical review. Psychological Medicine 16, 257–265.CrossRefGoogle ScholarPubMed
Rosenbaum, G., Mackavey, W. R. & Grisell, J. L. (1957). Effects of biological and social motivation on schizophrenic reaction time. Journal of Abnormal and Social Psychology 53, 364–368.CrossRefGoogle Scholar
Schonell, F. (1942). Backwardness in the Basic Subjects. Oliver and Boyd: Oxford.Google Scholar
Senf, R., Huston, P. E. & Cohen, B. D. (1955). Thinking deficit in schizophrenia and changes with Amytal. Journal of Abnormal and Social Psychology 50, 383–387.CrossRefGoogle ScholarPubMed
Shapiro, M. B. & Nelson, E. H. (1955). An investigation of the nature of cognitive impairment in co-operative patients. British Journal of Medical Psychology 28, 239–256.Google Scholar
Simpson, G. M. & Angus, J. W. S. (1970). A rating scale for extrapyramidal side-effects in drug-induced extrapyramidal disorders. Acta Psychiatrica Scandinavica 212, 11–19.CrossRefGoogle Scholar
Turner, T. H. (1989). Schizophrenia and mental handicap: an historical review, with implications for further research. Psychological Medicine 19, 301–314.Google Scholar
Watson, C. G., Thomas, R. W., Andersen, D. & Felling, J. (1968). Differentiation of organics from schizophrenics at two chronicity levels by use of the Reitan-Halstead organic test battery. Journal of Consulting and Clinical Psychology 32, 679–684.CrossRefGoogle ScholarPubMed
Wechsler, D. (1981). Wechsler Adult Intelligence Scale – Revised. The Psychological Corporation: New York.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979). Lateral cerebral ventricular enlargement in chronic schizophrenics. Archives of General Psychiatry 36, 735–739.CrossRefGoogle Scholar