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Cognitive dysfunction in schizophrenia followed up over 5 years, and its longitudinal relationship to the emergence of tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

John L. Waddington ,
Hanafy A. Youssef  and
Anthony Kinsella
John L. Waddington*
Affiliation:
Royal College of Surgeons in Ireland, Dublin; St Davnet's Hospital, Monaghan; Dublin Institute of Technology, Ireland
Hanafy A. Youssef
Affiliation:
Royal College of Surgeons in Ireland, Dublin; St Davnet's Hospital, Monaghan; Dublin Institute of Technology, Ireland
Anthony Kinsella
Affiliation:
Royal College of Surgeons in Ireland, Dublin; St Davnet's Hospital, Monaghan; Dublin Institute of Technology, Ireland
*
1Address for correspondence: Dr John L. Waddington, Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland.
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Synopsis

In this study, 51 chronic schizophrenic in-patients were evaluated for a range of demographic, clinical and medication variables, and followed up over five years. There was no significant overall change in cognitive function in this patient group as a whole, suggesting the absence of active disease at this stage of the illness. The only correlate of individual instances of cognitive deterioration over the study period was the emergence of new cases of tardive buccal-lingual-masticatory but not of limb-trunkal dyskinesia, and the greater severity of such movement disorder. A positive family history was also identified prospectively as a predictor of the emergence of tardive dyskinesia in chronic schizophrenia.

Type
Orginal Articles
Information
Psychological Medicine , Volume 20 , Issue 4 , November 1990 , pp. 835 - 842
Copyright
Copyright © Cambridge University Press 1990

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